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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PRKCSH
Full Name:
Glucosidase 2 subunit beta
Alias:
80K-H protein;Glucosidase II subunit beta;Protein kinase C substrate 60.1 kDa protein heavy chain
Type:
Mass (Da):
59425
Number AA:
528
UniProt ID:
P14314
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S24
V
K
R
P
R
G
V
S
L
T
N
H
H
F
Y
Site 2
T26
R
P
R
G
V
S
L
T
N
H
H
F
Y
D
E
Site 3
Y31
S
L
T
N
H
H
F
Y
D
E
S
K
P
F
T
Site 4
T38
Y
D
E
S
K
P
F
T
C
L
D
G
S
A
T
Site 5
Y55
F
D
Q
V
N
D
D
Y
C
D
C
K
D
G
S
Site 6
S62
Y
C
D
C
K
D
G
S
D
E
P
G
T
A
A
Site 7
T67
D
G
S
D
E
P
G
T
A
A
C
P
N
G
S
Site 8
T78
P
N
G
S
F
H
C
T
N
T
G
Y
K
P
L
Site 9
T80
G
S
F
H
C
T
N
T
G
Y
K
P
L
Y
I
Site 10
Y86
N
T
G
Y
K
P
L
Y
I
P
S
N
R
V
N
Site 11
S89
Y
K
P
L
Y
I
P
S
N
R
V
N
D
G
V
Site 12
Y106
C
C
D
G
T
D
E
Y
N
S
G
V
I
C
E
Site 13
T115
S
G
V
I
C
E
N
T
C
K
E
K
G
R
K
Site 14
S126
K
G
R
K
E
R
E
S
L
Q
Q
M
A
E
V
Site 15
S168
E
L
Q
A
G
K
K
S
L
E
D
Q
V
E
M
Site 16
T178
D
Q
V
E
M
L
R
T
V
K
E
E
A
E
K
Site 17
T228
L
D
D
D
M
D
G
T
V
S
V
T
E
L
Q
Site 18
S230
D
D
M
D
G
T
V
S
V
T
E
L
Q
T
H
Site 19
S249
T
D
G
D
G
A
L
S
E
A
E
A
Q
A
L
Site 20
T261
Q
A
L
L
S
G
D
T
Q
T
D
A
T
S
F
Site 21
T263
L
L
S
G
D
T
Q
T
D
A
T
S
F
Y
D
Site 22
Y269
Q
T
D
A
T
S
F
Y
D
R
V
W
A
A
I
Site 23
Y280
W
A
A
I
R
D
K
Y
R
S
E
A
L
P
T
Site 24
S282
A
I
R
D
K
Y
R
S
E
A
L
P
T
D
L
Site 25
T287
Y
R
S
E
A
L
P
T
D
L
P
A
P
S
A
Site 26
S293
P
T
D
L
P
A
P
S
A
P
D
L
T
E
P
Site 27
T298
A
P
S
A
P
D
L
T
E
P
K
E
E
Q
P
Site 28
S310
E
Q
P
P
V
P
S
S
P
T
E
E
E
E
E
Site 29
S335
E
E
E
E
E
E
D
S
E
E
A
P
P
P
L
Site 30
S343
E
E
A
P
P
P
L
S
P
P
Q
P
A
S
P
Site 31
S349
L
S
P
P
Q
P
A
S
P
A
E
E
D
K
M
Site 32
Y359
E
E
D
K
M
P
P
Y
D
E
Q
T
Q
A
F
Site 33
S383
K
F
E
E
A
E
R
S
L
K
D
M
E
E
S
Site 34
S390
S
L
K
D
M
E
E
S
I
R
N
L
E
Q
E
Site 35
S399
R
N
L
E
Q
E
I
S
F
D
F
G
P
N
G
Site 36
Y410
G
P
N
G
E
F
A
Y
L
Y
S
Q
C
Y
E
Site 37
Y412
N
G
E
F
A
Y
L
Y
S
Q
C
Y
E
L
T
Site 38
Y416
A
Y
L
Y
S
Q
C
Y
E
L
T
T
N
E
Y
Site 39
Y423
Y
E
L
T
T
N
E
Y
V
Y
R
L
C
P
F
Site 40
S434
L
C
P
F
K
L
V
S
Q
K
P
K
L
G
G
Site 41
S442
Q
K
P
K
L
G
G
S
P
T
S
L
G
T
W
Site 42
T444
P
K
L
G
G
S
P
T
S
L
G
T
W
G
S
Site 43
S445
K
L
G
G
S
P
T
S
L
G
T
W
G
S
W
Site 44
T448
G
S
P
T
S
L
G
T
W
G
S
W
I
G
P
Site 45
S451
T
S
L
G
T
W
G
S
W
I
G
P
D
H
D
Site 46
S461
G
P
D
H
D
K
F
S
A
M
K
Y
E
Q
G
Site 47
Y465
D
K
F
S
A
M
K
Y
E
Q
G
T
G
C
W
Site 48
T479
W
Q
G
P
N
R
S
T
T
V
R
L
L
C
G
Site 49
T480
Q
G
P
N
R
S
T
T
V
R
L
L
C
G
K
Site 50
T489
R
L
L
C
G
K
E
T
M
V
T
S
T
T
E
Site 51
T492
C
G
K
E
T
M
V
T
S
T
T
E
P
S
R
Site 52
S493
G
K
E
T
M
V
T
S
T
T
E
P
S
R
C
Site 53
T494
K
E
T
M
V
T
S
T
T
E
P
S
R
C
E
Site 54
S498
V
T
S
T
T
E
P
S
R
C
E
Y
L
M
E
Site 55
Y502
T
E
P
S
R
C
E
Y
L
M
E
L
M
T
P
Site 56
T508
E
Y
L
M
E
L
M
T
P
A
A
C
P
E
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation