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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FDPS
Full Name:
Farnesyl pyrophosphate synthase
Alias:
Transferase, Lipid Metabolism group, Biosynthesis of steroids family, Biosynthesis of Secondary Metabolites group, Terpenoid biosynthesis family
Type:
Lipid transferase
Mass (Da):
48275
Number AA:
419
UniProt ID:
P14324
International Prot ID:
IPI00797614
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0004161
GO:0004337
PhosphoSite+
KinaseNET
Biological Process:
GO:0006695
GO:0044419
GO:0008299
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y19
V
F
L
L
P
A
P
Y
W
A
P
R
E
R
W
Site 2
S29
P
R
E
R
W
L
G
S
L
R
R
P
S
L
V
Site 3
S34
L
G
S
L
R
R
P
S
L
V
H
G
Y
P
V
Site 4
Y39
R
P
S
L
V
H
G
Y
P
V
L
A
W
H
S
Site 5
S64
E
P
R
A
L
C
S
S
L
R
M
N
G
D
Q
Site 6
S73
R
M
N
G
D
Q
N
S
D
V
Y
A
Q
E
K
Site 7
Y76
G
D
Q
N
S
D
V
Y
A
Q
E
K
Q
D
F
Site 8
T95
S
Q
I
V
R
V
L
T
E
D
E
M
G
H
P
Site 9
Y117
R
L
K
E
V
L
E
Y
N
A
I
G
G
K
Y
Site 10
Y124
Y
N
A
I
G
G
K
Y
N
R
G
L
T
V
V
Site 11
T129
G
K
Y
N
R
G
L
T
V
V
V
A
F
R
E
Site 12
S147
P
R
K
Q
D
A
D
S
L
Q
R
A
W
T
V
Site 13
S174
V
A
D
D
I
M
D
S
S
L
T
R
R
G
Q
Site 14
S175
A
D
D
I
M
D
S
S
L
T
R
R
G
Q
I
Site 15
Y185
R
R
G
Q
I
C
W
Y
Q
K
P
G
V
G
L
Site 16
Y212
I
Y
R
L
L
K
L
Y
C
R
E
Q
P
Y
Y
Site 17
Y219
Y
C
R
E
Q
P
Y
Y
L
N
L
I
E
L
F
Site 18
S230
I
E
L
F
L
Q
S
S
Y
Q
T
E
I
G
Q
Site 19
T233
F
L
Q
S
S
Y
Q
T
E
I
G
Q
T
L
D
Site 20
T238
Y
Q
T
E
I
G
Q
T
L
D
L
L
T
A
P
Site 21
T243
G
Q
T
L
D
L
L
T
A
P
Q
G
N
V
D
Site 22
T255
N
V
D
L
V
R
F
T
E
K
R
Y
K
S
I
Site 23
S261
F
T
E
K
R
Y
K
S
I
V
K
Y
K
T
A
Site 24
Y265
R
Y
K
S
I
V
K
Y
K
T
A
F
Y
S
F
Site 25
T267
K
S
I
V
K
Y
K
T
A
F
Y
S
F
Y
L
Site 26
Y273
K
T
A
F
Y
S
F
Y
L
P
I
A
A
A
M
Site 27
Y311
F
F
Q
I
Q
D
D
Y
L
D
L
F
G
D
P
Site 28
T345
V
Q
C
L
Q
R
A
T
P
E
Q
Y
Q
I
L
Site 29
Y383
L
P
A
V
F
L
Q
Y
E
E
D
S
Y
S
H
Site 30
Y388
L
Q
Y
E
E
D
S
Y
S
H
I
M
A
L
I
Site 31
S389
Q
Y
E
E
D
S
Y
S
H
I
M
A
L
I
E
Site 32
Y415
L
G
L
A
R
K
I
Y
K
R
R
K
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation