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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SI
Full Name:
Sucrase-isomaltase, intestinal
Alias:
Alpha-glucosidase; Isomaltase; Oligosaccharide alpha-1,6-glucosidase; Sucrase-isomaltase; SUIS
Type:
Carbohydrate Metabolism - starch and sucrose; EC 3.2.1.48; Hydrolase; EC 3.2.1.10
Mass (Da):
209405
Number AA:
1827
UniProt ID:
P14410
International Prot ID:
IPI00221101
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0005903
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0004574
GO:0004575
PhosphoSite+
KinaseNET
Biological Process:
GO:0005975
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S42
T
P
A
V
D
E
I
S
D
S
T
S
T
P
A
Site 2
S44
A
V
D
E
I
S
D
S
T
S
T
P
A
T
T
Site 3
T45
V
D
E
I
S
D
S
T
S
T
P
A
T
T
R
Site 4
S46
D
E
I
S
D
S
T
S
T
P
A
T
T
R
V
Site 5
T47
E
I
S
D
S
T
S
T
P
A
T
T
R
V
T
Site 6
T50
D
S
T
S
T
P
A
T
T
R
V
T
T
N
P
Site 7
T54
T
P
A
T
T
R
V
T
T
N
P
S
D
S
G
Site 8
T55
P
A
T
T
R
V
T
T
N
P
S
D
S
G
K
Site 9
S58
T
R
V
T
T
N
P
S
D
S
G
K
C
P
N
Site 10
T120
G
Y
N
V
Q
D
M
T
T
T
S
I
G
V
E
Site 11
S135
A
K
L
N
R
I
P
S
P
T
L
F
G
N
D
Site 12
T137
L
N
R
I
P
S
P
T
L
F
G
N
D
I
N
Site 13
T149
D
I
N
S
V
L
F
T
T
Q
N
Q
T
P
N
Site 14
T154
L
F
T
T
Q
N
Q
T
P
N
R
F
R
F
K
Site 15
Y170
T
D
P
N
N
R
R
Y
E
V
P
H
Q
Y
V
Site 16
Y176
R
Y
E
V
P
H
Q
Y
V
K
E
F
T
G
P
Site 17
T184
V
K
E
F
T
G
P
T
V
S
D
T
L
Y
D
Site 18
S186
E
F
T
G
P
T
V
S
D
T
L
Y
D
V
K
Site 19
T188
T
G
P
T
V
S
D
T
L
Y
D
V
K
V
A
Site 20
Y190
P
T
V
S
D
T
L
Y
D
V
K
V
A
Q
N
Site 21
S200
K
V
A
Q
N
P
F
S
I
Q
V
I
R
K
S
Site 22
S207
S
I
Q
V
I
R
K
S
N
G
K
T
L
F
D
Site 23
T211
I
R
K
S
N
G
K
T
L
F
D
T
S
I
G
Site 24
Y226
P
L
V
Y
S
D
Q
Y
L
Q
I
S
A
R
L
Site 25
S230
S
D
Q
Y
L
Q
I
S
A
R
L
P
S
D
Y
Site 26
S235
Q
I
S
A
R
L
P
S
D
Y
I
Y
G
I
G
Site 27
Y237
S
A
R
L
P
S
D
Y
I
Y
G
I
G
E
Q
Site 28
Y239
R
L
P
S
D
Y
I
Y
G
I
G
E
Q
V
H
Site 29
Y275
G
D
N
N
N
N
L
Y
G
H
Q
T
F
F
M
Site 30
Y338
P
E
Q
V
V
Q
Q
Y
Q
Q
L
V
G
L
P
Site 31
Y362
F
Q
L
S
R
W
N
Y
K
S
L
D
V
V
K
Site 32
S364
L
S
R
W
N
Y
K
S
L
D
V
V
K
E
V
Site 33
T384
E
A
G
I
P
F
D
T
Q
V
T
D
I
D
Y
Site 34
Y391
T
Q
V
T
D
I
D
Y
M
E
D
K
K
D
F
Site 35
Y400
E
D
K
K
D
F
T
Y
D
Q
V
A
F
N
G
Site 36
Y422
L
H
D
H
G
Q
K
Y
V
I
I
L
D
P
A
Site 37
T439
I
G
R
R
A
N
G
T
T
Y
A
T
Y
E
R
Site 38
T440
G
R
R
A
N
G
T
T
Y
A
T
Y
E
R
G
Site 39
Y441
R
R
A
N
G
T
T
Y
A
T
Y
E
R
G
N
Site 40
Y444
N
G
T
T
Y
A
T
Y
E
R
G
N
T
Q
H
Site 41
S460
W
I
N
E
S
D
G
S
T
P
I
I
G
E
V
Site 42
T461
I
N
E
S
D
G
S
T
P
I
I
G
E
V
W
Site 43
T472
G
E
V
W
P
G
L
T
V
Y
P
D
F
T
N
Site 44
Y474
V
W
P
G
L
T
V
Y
P
D
F
T
N
P
N
Site 45
S511
I
D
M
N
E
V
S
S
F
I
Q
G
S
T
K
Site 46
Y527
C
N
V
N
K
L
N
Y
P
P
F
T
P
D
I
Site 47
T531
K
L
N
Y
P
P
F
T
P
D
I
L
D
K
L
Site 48
Y540
D
I
L
D
K
L
M
Y
S
K
T
I
C
M
D
Site 49
Y556
V
Q
N
W
G
K
Q
Y
D
V
H
S
L
Y
G
Site 50
S560
G
K
Q
Y
D
V
H
S
L
Y
G
Y
S
M
A
Site 51
Y562
Q
Y
D
V
H
S
L
Y
G
Y
S
M
A
I
A
Site 52
S583
K
V
F
P
N
K
R
S
F
I
L
T
R
S
T
Site 53
T587
N
K
R
S
F
I
L
T
R
S
T
F
A
G
S
Site 54
S589
R
S
F
I
L
T
R
S
T
F
A
G
S
G
R
Site 55
T590
S
F
I
L
T
R
S
T
F
A
G
S
G
R
H
Site 56
S594
T
R
S
T
F
A
G
S
G
R
H
A
A
H
W
Site 57
T617
E
Q
M
E
W
S
I
T
G
M
L
E
F
S
L
Site 58
S659
L
G
A
F
Y
P
F
S
R
N
H
N
S
D
G
Site 59
S664
P
F
S
R
N
H
N
S
D
G
Y
E
H
Q
D
Site 60
Y667
R
N
H
N
S
D
G
Y
E
H
Q
D
P
A
F
Site 61
S679
P
A
F
F
G
Q
N
S
L
L
V
K
S
S
R
Site 62
S684
Q
N
S
L
L
V
K
S
S
R
Q
Y
L
T
I
Site 63
S685
N
S
L
L
V
K
S
S
R
Q
Y
L
T
I
R
Site 64
Y688
L
V
K
S
S
R
Q
Y
L
T
I
R
Y
T
L
Site 65
T690
K
S
S
R
Q
Y
L
T
I
R
Y
T
L
L
P
Site 66
Y722
R
P
V
L
H
E
F
Y
E
D
T
N
S
W
I
Site 67
T752
V
L
K
Q
G
A
D
T
V
S
A
Y
I
P
D
Site 68
S754
K
Q
G
A
D
T
V
S
A
Y
I
P
D
A
I
Site 69
Y763
Y
I
P
D
A
I
W
Y
D
Y
E
S
G
A
K
Site 70
Y765
P
D
A
I
W
Y
D
Y
E
S
G
A
K
R
P
Site 71
Y781
R
K
Q
R
V
D
M
Y
L
P
A
D
K
I
G
Site 72
T805
P
I
Q
E
P
D
V
T
T
T
A
S
R
K
N
Site 73
T840
D
D
G
E
T
K
D
T
I
Q
N
G
N
Y
I
Site 74
Y849
Q
N
G
N
Y
I
L
Y
T
F
S
V
S
N
N
Site 75
T850
N
G
N
Y
I
L
Y
T
F
S
V
S
N
N
T
Site 76
S852
N
Y
I
L
Y
T
F
S
V
S
N
N
T
L
D
Site 77
S866
D
I
V
C
T
H
S
S
Y
Q
E
G
T
T
L
Site 78
T888
L
G
L
T
D
S
V
T
E
V
R
V
A
E
N
Site 79
Y907
N
A
H
S
N
F
T
Y
D
A
S
N
Q
V
L
Site 80
Y944
E
N
E
R
F
N
C
Y
P
D
A
D
L
A
T
Site 81
S966
G
C
V
W
R
T
G
S
S
L
S
K
A
P
E
Site 82
S967
C
V
W
R
T
G
S
S
L
S
K
A
P
E
C
Site 83
S969
W
R
T
G
S
S
L
S
K
A
P
E
C
Y
F
Site 84
Y975
L
S
K
A
P
E
C
Y
F
P
R
Q
D
N
S
Site 85
S982
Y
F
P
R
Q
D
N
S
Y
S
V
N
S
A
R
Site 86
Y983
F
P
R
Q
D
N
S
Y
S
V
N
S
A
R
Y
Site 87
S984
P
R
Q
D
N
S
Y
S
V
N
S
A
R
Y
S
Site 88
S987
D
N
S
Y
S
V
N
S
A
R
Y
S
S
M
G
Site 89
S991
S
V
N
S
A
R
Y
S
S
M
G
I
T
A
D
Site 90
S992
V
N
S
A
R
Y
S
S
M
G
I
T
A
D
L
Site 91
T996
R
Y
S
S
M
G
I
T
A
D
L
Q
L
N
T
Site 92
T1003
T
A
D
L
Q
L
N
T
A
N
A
R
I
K
L
Site 93
S1012
N
A
R
I
K
L
P
S
D
P
I
S
T
L
R
Site 94
S1016
K
L
P
S
D
P
I
S
T
L
R
V
E
V
K
Site 95
T1017
L
P
S
D
P
I
S
T
L
R
V
E
V
K
Y
Site 96
Y1024
T
L
R
V
E
V
K
Y
H
K
N
D
M
L
Q
Site 97
Y1035
D
M
L
Q
F
K
I
Y
D
P
Q
K
K
R
Y
Site 98
Y1042
Y
D
P
Q
K
K
R
Y
E
V
P
V
P
L
N
Site 99
T1052
P
V
P
L
N
I
P
T
T
P
I
S
T
Y
E
Site 100
T1053
V
P
L
N
I
P
T
T
P
I
S
T
Y
E
D
Site 101
S1056
N
I
P
T
T
P
I
S
T
Y
E
D
R
L
Y
Site 102
Y1058
P
T
T
P
I
S
T
Y
E
D
R
L
Y
D
V
Site 103
Y1063
S
T
Y
E
D
R
L
Y
D
V
E
I
K
E
N
Site 104
S1080
G
I
Q
I
R
R
R
S
S
G
R
V
I
W
D
Site 105
S1081
I
Q
I
R
R
R
S
S
G
R
V
I
W
D
S
Site 106
S1103
N
D
Q
F
I
Q
I
S
T
R
L
P
S
E
Y
Site 107
T1104
D
Q
F
I
Q
I
S
T
R
L
P
S
E
Y
I
Site 108
S1108
Q
I
S
T
R
L
P
S
E
Y
I
Y
G
F
G
Site 109
Y1110
S
T
R
L
P
S
E
Y
I
Y
G
F
G
E
V
Site 110
Y1112
R
L
P
S
E
Y
I
Y
G
F
G
E
V
E
H
Site 111
T1120
G
F
G
E
V
E
H
T
A
F
K
R
D
L
N
Site 112
Y1142
T
R
D
Q
P
P
G
Y
K
L
N
S
Y
G
F
Site 113
Y1147
P
G
Y
K
L
N
S
Y
G
F
H
P
Y
Y
M
Site 114
Y1153
S
Y
G
F
H
P
Y
Y
M
A
L
E
E
E
G
Site 115
T1176
N
S
N
A
M
D
V
T
F
Q
P
T
P
A
L
Site 116
T1180
M
D
V
T
F
Q
P
T
P
A
L
T
Y
R
T
Site 117
T1201
F
Y
M
F
L
G
P
T
P
E
V
A
T
K
Q
Site 118
Y1209
P
E
V
A
T
K
Q
Y
H
E
V
I
G
H
P
Site 119
Y1231
L
G
F
Q
L
C
R
Y
G
Y
A
N
T
S
E
Site 120
Y1233
F
Q
L
C
R
Y
G
Y
A
N
T
S
E
V
R
Site 121
S1237
R
Y
G
Y
A
N
T
S
E
V
R
E
L
Y
D
Site 122
Y1243
T
S
E
V
R
E
L
Y
D
A
M
V
A
A
N
Site 123
Y1257
N
I
P
Y
D
V
Q
Y
T
D
I
D
Y
M
E
Site 124
Y1262
V
Q
Y
T
D
I
D
Y
M
E
R
Q
L
D
F
Site 125
T1270
M
E
R
Q
L
D
F
T
I
G
E
A
F
Q
D
Site 126
S1301
I
I
L
D
P
A
I
S
G
N
E
T
K
T
Y
Site 127
T1305
P
A
I
S
G
N
E
T
K
T
Y
P
A
F
E
Site 128
T1307
I
S
G
N
E
T
K
T
Y
P
A
F
E
R
G
Site 129
Y1308
S
G
N
E
T
K
T
Y
P
A
F
E
R
G
Q
Site 130
T1346
P
N
I
T
I
D
K
T
L
T
E
D
E
A
V
Site 131
T1370
P
D
F
F
R
T
S
T
A
E
W
W
A
R
E
Site 132
Y1382
A
R
E
I
V
D
F
Y
N
E
K
M
K
F
D
Site 133
S1400
I
D
M
N
E
P
S
S
F
V
N
G
T
T
T
Site 134
Y1417
C
R
N
D
E
L
N
Y
P
P
Y
F
P
E
L
Site 135
Y1420
D
E
L
N
Y
P
P
Y
F
P
E
L
T
K
R
Site 136
T1425
P
P
Y
F
P
E
L
T
K
R
T
D
G
L
H
Site 137
S1445
M
E
A
E
Q
I
L
S
D
G
T
S
V
L
H
Site 138
S1449
Q
I
L
S
D
G
T
S
V
L
H
Y
D
V
H
Site 139
Y1453
D
G
T
S
V
L
H
Y
D
V
H
N
L
Y
G
Site 140
T1474
T
H
D
A
L
Q
K
T
T
G
K
R
G
I
V
Site 141
S1483
G
K
R
G
I
V
I
S
R
S
T
Y
P
T
S
Site 142
S1485
R
G
I
V
I
S
R
S
T
Y
P
T
S
G
R
Site 143
T1486
G
I
V
I
S
R
S
T
Y
P
T
S
G
R
W
Site 144
Y1487
I
V
I
S
R
S
T
Y
P
T
S
G
R
W
G
Site 145
T1489
I
S
R
S
T
Y
P
T
S
G
R
W
G
G
H
Site 146
Y1554
Q
L
G
A
F
Y
P
Y
S
R
N
H
N
I
A
Site 147
S1570
T
R
R
Q
D
P
A
S
W
N
E
T
F
A
E
Site 148
T1574
D
P
A
S
W
N
E
T
F
A
E
M
S
R
N
Site 149
Y1592
I
R
Y
T
L
L
P
Y
F
Y
T
Q
M
H
E
Site 150
Y1650
Y
V
Q
T
V
N
A
Y
V
P
N
A
R
W
F
Site 151
Y1659
P
N
A
R
W
F
D
Y
H
T
G
K
D
I
G
Site 152
T1661
A
R
W
F
D
Y
H
T
G
K
D
I
G
V
R
Site 153
T1673
G
V
R
G
Q
F
Q
T
F
N
A
S
Y
D
T
Site 154
Y1678
F
Q
T
F
N
A
S
Y
D
T
I
N
L
H
V
Site 155
Y1702
E
P
A
Q
N
T
F
Y
S
R
Q
K
H
M
K
Site 156
T1734
D
D
G
E
S
I
D
T
Y
E
R
D
L
Y
L
Site 157
Y1735
D
G
E
S
I
D
T
Y
E
R
D
L
Y
L
S
Site 158
Y1740
D
T
Y
E
R
D
L
Y
L
S
V
Q
F
N
L
Site 159
S1742
Y
E
R
D
L
Y
L
S
V
Q
F
N
L
N
Q
Site 160
Y1761
S
T
I
L
K
R
G
Y
I
N
K
S
E
T
R
Site 161
S1765
K
R
G
Y
I
N
K
S
E
T
R
L
G
S
L
Site 162
T1767
G
Y
I
N
K
S
E
T
R
L
G
S
L
H
V
Site 163
S1771
K
S
E
T
R
L
G
S
L
H
V
W
G
K
G
Site 164
S1795
T
Y
N
G
N
K
N
S
L
P
F
N
E
D
T
Site 165
T1802
S
L
P
F
N
E
D
T
T
N
M
I
L
R
I
Site 166
T1803
L
P
F
N
E
D
T
T
N
M
I
L
R
I
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation