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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
AKR1B1
Full Name:
Aldose reductase
Alias:
ADR; Aldehyde reductase 1; Aldo-keto reductase family 1, member B1 (aldose reductase); Aldose reductase; ALDR; ALDR1; AR; EC 1.1.1.21; Lii5-2 CTCL tumor antigen; Low Km aldose reductase
Type:
Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - galactose; Oxidoreductase; EC 1.1.1.21; Lipid Metabolism - glycerolipid; Carbohydrate Metabolism - pyruvate; Carbohydrate Metabolism - pentose and glucuronate interconversions
Mass (Da):
35853
Number AA:
316
UniProt ID:
P15121
International Prot ID:
IPI00413641
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005615
Uniprot
OncoNet
Molecular Function:
GO:0004032
GO:0009055
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0005975
GO:0055114
GO:0006950
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S3
_
_
_
_
_
M
A
S
R
L
L
L
N
N
G
Site 2
T20
M
P
I
L
G
L
G
T
W
K
S
P
P
G
Q
Site 3
S23
L
G
L
G
T
W
K
S
P
P
G
Q
V
T
E
Site 4
Y40
K
V
A
I
D
V
G
Y
R
H
I
D
C
A
H
Site 5
Y49
H
I
D
C
A
H
V
Y
Q
N
E
N
E
V
G
Site 6
Y83
V
S
K
L
W
C
T
Y
H
E
K
G
L
V
K
Site 7
T96
V
K
G
A
C
Q
K
T
L
S
D
L
K
L
D
Site 8
S98
G
A
C
Q
K
T
L
S
D
L
K
L
D
Y
L
Site 9
Y104
L
S
D
L
K
L
D
Y
L
D
L
Y
L
I
H
Site 10
Y108
K
L
D
Y
L
D
L
Y
L
I
H
W
P
T
G
Site 11
S128
E
F
F
P
L
D
E
S
G
N
V
V
P
S
D
Site 12
S134
E
S
G
N
V
V
P
S
D
T
N
I
L
D
T
Site 13
T141
S
D
T
N
I
L
D
T
W
A
A
M
E
E
L
Site 14
Y190
H
I
D
C
A
H
V
Y
Q
N
E
N
E
V
G
Site 15
T192
I
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
Site 16
Y199
T
Q
E
K
L
I
Q
Y
C
Q
S
K
G
I
V
Site 17
Y210
K
G
I
V
V
T
A
Y
S
P
L
G
S
P
D
Site 18
S215
T
A
Y
S
P
L
G
S
P
D
R
P
W
A
K
Site 19
S227
W
A
K
P
E
D
P
S
L
L
E
D
P
R
I
Site 20
T244
I
A
A
K
H
N
K
T
T
A
Q
V
L
I
R
Site 21
T266
V
V
I
P
K
S
V
T
P
E
R
I
A
E
N
Site 22
T287
E
L
S
S
Q
D
M
T
T
L
L
S
Y
N
R
Site 23
T288
L
S
S
Q
D
M
T
T
L
L
S
Y
N
R
N
Site 24
Y292
D
M
T
T
L
L
S
Y
N
R
N
W
R
V
C
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation