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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ANPEP
Full Name:
Aminopeptidase N
Alias:
Aminopeptidase M; Aminopeptidase N; AMPN; APN; CD13; EC 3.4.11.2; Gp150; LAP1; Microsomal aminopeptidase; Myeloid plasma membrane glycoprotein CD13; PEPN
Type:
Enzyme, aminopeptidase
Mass (Da):
109540
Number AA:
967
UniProt ID:
P15144
International Prot ID:
IPI00221224
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005793
GO:0005829
GO:0005887
Uniprot
OncoNet
Molecular Function:
GO:0004177
GO:0008237
GO:0004872
PhosphoSite+
KinaseNET
Biological Process:
GO:0001525
GO:0030154
GO:0044419
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S34
I
A
L
S
V
V
Y
S
Q
E
K
N
K
N
A
Site 2
S43
E
K
N
K
N
A
N
S
S
P
V
A
S
T
T
Site 3
S44
K
N
K
N
A
N
S
S
P
V
A
S
T
T
P
Site 4
S48
A
N
S
S
P
V
A
S
T
T
P
S
A
S
A
Site 5
T50
S
S
P
V
A
S
T
T
P
S
A
S
A
T
T
Site 6
S52
P
V
A
S
T
T
P
S
A
S
A
T
T
N
P
Site 7
S54
A
S
T
T
P
S
A
S
A
T
T
N
P
A
S
Site 8
T56
T
T
P
S
A
S
A
T
T
N
P
A
S
A
T
Site 9
S61
S
A
T
T
N
P
A
S
A
T
T
L
D
Q
S
Site 10
S68
S
A
T
T
L
D
Q
S
K
A
W
N
R
Y
R
Site 11
Y74
Q
S
K
A
W
N
R
Y
R
L
P
N
T
L
K
Site 12
T79
N
R
Y
R
L
P
N
T
L
K
P
D
S
Y
R
Site 13
S84
P
N
T
L
K
P
D
S
Y
R
V
T
L
R
P
Site 14
Y85
N
T
L
K
P
D
S
Y
R
V
T
L
R
P
Y
Site 15
T88
K
P
D
S
Y
R
V
T
L
R
P
Y
L
T
P
Site 16
Y92
Y
R
V
T
L
R
P
Y
L
T
P
N
D
R
G
Site 17
T94
V
T
L
R
P
Y
L
T
P
N
D
R
G
L
Y
Site 18
Y101
T
P
N
D
R
G
L
Y
V
F
K
G
S
S
T
Site 19
T108
Y
V
F
K
G
S
S
T
V
R
F
T
C
K
E
Site 20
T112
G
S
S
T
V
R
F
T
C
K
E
A
T
D
V
Site 21
Y129
I
H
S
K
K
L
N
Y
T
L
S
Q
G
H
R
Site 22
T130
H
S
K
K
L
N
Y
T
L
S
Q
G
H
R
V
Site 23
S132
K
K
L
N
Y
T
L
S
Q
G
H
R
V
V
L
Site 24
S145
V
L
R
G
V
G
G
S
Q
P
P
D
I
D
K
Site 25
T153
Q
P
P
D
I
D
K
T
E
L
V
E
P
T
E
Site 26
S174
K
G
S
L
V
K
D
S
Q
Y
E
M
D
S
E
Site 27
Y176
S
L
V
K
D
S
Q
Y
E
M
D
S
E
F
E
Site 28
S180
D
S
Q
Y
E
M
D
S
E
F
E
G
E
L
A
Site 29
S196
D
L
A
G
F
Y
R
S
E
Y
M
E
G
N
V
Site 30
Y198
A
G
F
Y
R
S
E
Y
M
E
G
N
V
R
K
Site 31
S220
Q
A
A
D
A
R
K
S
F
P
C
F
D
E
P
Site 32
T236
M
K
A
E
F
N
I
T
L
I
H
P
K
D
L
Site 33
S247
P
K
D
L
T
A
L
S
N
M
L
P
K
G
P
Site 34
T256
M
L
P
K
G
P
S
T
P
L
P
E
D
P
N
Site 35
T272
N
V
T
E
F
H
T
T
P
K
M
S
T
Y
L
Site 36
Y289
F
I
V
S
E
F
D
Y
V
E
K
Q
A
S
N
Site 37
Y332
L
N
F
F
A
G
H
Y
D
T
P
Y
P
L
P
Site 38
T334
F
F
A
G
H
Y
D
T
P
Y
P
L
P
K
S
Site 39
Y336
A
G
H
Y
D
T
P
Y
P
L
P
K
S
D
Q
Site 40
S341
T
P
Y
P
L
P
K
S
D
Q
I
G
L
P
D
Site 41
T361
M
E
N
W
G
L
V
T
Y
R
E
N
S
L
L
Site 42
Y362
E
N
W
G
L
V
T
Y
R
E
N
S
L
L
F
Site 43
S366
L
V
T
Y
R
E
N
S
L
L
F
D
P
L
S
Site 44
S373
S
L
L
F
D
P
L
S
S
S
S
S
N
K
E
Site 45
S374
L
L
F
D
P
L
S
S
S
S
S
N
K
E
R
Site 46
S375
L
F
D
P
L
S
S
S
S
S
N
K
E
R
V
Site 47
S377
D
P
L
S
S
S
S
S
N
K
E
R
V
V
T
Site 48
T384
S
N
K
E
R
V
V
T
V
I
A
H
E
L
A
Site 49
Y416
L
N
E
G
F
A
S
Y
V
E
Y
L
G
A
D
Site 50
Y419
G
F
A
S
Y
V
E
Y
L
G
A
D
Y
A
E
Site 51
Y424
V
E
Y
L
G
A
D
Y
A
E
P
T
W
N
L
Site 52
S456
L
A
S
S
H
P
L
S
T
P
A
S
E
I
N
Site 53
T457
A
S
S
H
P
L
S
T
P
A
S
E
I
N
T
Site 54
S460
H
P
L
S
T
P
A
S
E
I
N
T
P
A
Q
Site 55
T464
T
P
A
S
E
I
N
T
P
A
Q
I
S
E
L
Site 56
S476
S
E
L
F
D
A
I
S
Y
S
K
G
A
S
V
Site 57
S492
R
M
L
S
S
F
L
S
E
D
V
F
K
Q
G
Site 58
Y503
F
K
Q
G
L
A
S
Y
L
H
T
F
A
Y
Q
Site 59
Y509
S
Y
L
H
T
F
A
Y
Q
N
T
I
Y
L
N
Site 60
Y514
F
A
Y
Q
N
T
I
Y
L
N
L
W
D
H
L
Site 61
T535
R
S
I
Q
L
P
T
T
V
R
D
I
M
N
R
Site 62
T558
V
I
T
V
D
T
S
T
G
T
L
S
Q
E
H
Site 63
S562
D
T
S
T
G
T
L
S
Q
E
H
F
L
L
D
Site 64
S572
H
F
L
L
D
P
D
S
N
V
T
R
P
S
E
Site 65
Y582
T
R
P
S
E
F
N
Y
V
W
I
V
P
I
T
Site 66
T589
Y
V
W
I
V
P
I
T
S
I
R
D
G
R
Q
Site 67
S590
V
W
I
V
P
I
T
S
I
R
D
G
R
Q
Q
Site 68
Y600
D
G
R
Q
Q
Q
D
Y
W
L
I
D
V
R
A
Site 69
S613
R
A
Q
N
D
L
F
S
T
S
G
N
E
W
V
Site 70
Y629
L
N
L
N
V
T
G
Y
Y
R
V
N
Y
D
E
Site 71
Y634
T
G
Y
Y
R
V
N
Y
D
E
E
N
W
R
K
Site 72
S651
T
Q
L
Q
R
D
H
S
A
I
P
V
I
N
R
Site 73
Y692
F
L
I
E
E
R
Q
Y
M
P
W
E
A
A
L
Site 74
S712
F
K
L
M
F
D
R
S
E
V
Y
G
P
M
K
Site 75
Y715
M
F
D
R
S
E
V
Y
G
P
M
K
N
Y
L
Site 76
T727
N
Y
L
K
K
Q
V
T
P
L
F
I
H
F
R
Site 77
Y751
P
E
N
L
M
D
Q
Y
S
E
V
N
A
I
S
Site 78
S752
E
N
L
M
D
Q
Y
S
E
V
N
A
I
S
T
Site 79
S762
N
A
I
S
T
A
C
S
N
G
V
P
E
C
E
Site 80
Y797
P
N
L
R
S
T
V
Y
C
N
A
I
A
Q
G
Site 81
T820
W
E
Q
F
R
N
A
T
L
V
N
E
A
D
K
Site 82
Y844
E
L
W
I
L
N
R
Y
L
S
Y
T
L
N
P
Site 83
S846
W
I
L
N
R
Y
L
S
Y
T
L
N
P
D
L
Site 84
T848
L
N
R
Y
L
S
Y
T
L
N
P
D
L
I
R
Site 85
S861
I
R
K
Q
D
A
T
S
T
I
I
S
I
T
N
Site 86
Y891
W
K
K
L
F
N
D
Y
G
G
G
S
F
S
F
Site 87
S895
F
N
D
Y
G
G
G
S
F
S
F
S
N
L
I
Site 88
S897
D
Y
G
G
G
S
F
S
F
S
N
L
I
Q
A
Site 89
T906
S
N
L
I
Q
A
V
T
R
R
F
S
T
E
Y
Site 90
S910
Q
A
V
T
R
R
F
S
T
E
Y
E
L
Q
Q
Site 91
T911
A
V
T
R
R
F
S
T
E
Y
E
L
Q
Q
L
Site 92
Y913
T
R
R
F
S
T
E
Y
E
L
Q
Q
L
E
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation