PhosphoNET

           
Protein Info 
   
Short Name:  AREG
Full Name:  Amphiregulin
Alias:  AR; Colorectum cell-derived growth factor; CRDGF; Schwannoma-derived growth factor; SDGF
Type:  Secreted protein
Mass (Da):  27895
Number AA:  252
UniProt ID:  P15514
International Prot ID:  IPI00012023
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0009986  GO:0005615  GO:0016021 Uniprot OncoNet
Molecular Function:  GO:0005125  GO:0008083   PhosphoSite+ KinaseNET
Biological Process:  GO:0007186  GO:0008283  GO:0007267 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1T32AGLDLNDTYSGKREP
Site 2Y33GLDLNDTYSGKREPF
Site 3S34LDLNDTYSGKREPFS
Site 4S41SGKREPFSGDHSADG
Site 5S45EPFSGDHSADGFEVT
Site 6T52SADGFEVTSRSEMSS
Site 7S53ADGFEVTSRSEMSSG
Site 8S55GFEVTSRSEMSSGSE
Site 9S59TSRSEMSSGSEISPV
Site 10S61RSEMSSGSEISPVSE
Site 11S64MSSGSEISPVSEMPS
Site 12S67GSEISPVSEMPSSSE
Site 13S71SPVSEMPSSSEPSSG
Site 14S72PVSEMPSSSEPSSGA
Site 15S73VSEMPSSSEPSSGAD
Site 16S76MPSSSEPSSGADYDY
Site 17S77PSSSEPSSGADYDYS
Site 18Y81EPSSGADYDYSEEYD
Site 19Y83SSGADYDYSEEYDNE
Site 20S84SGADYDYSEEYDNEP
Site 21Y96NEPQIPGYIVDDSVR
Site 22T115VKPPQNKTESENTSD
Site 23S117PPQNKTESENTSDKP
Site 24S121KTESENTSDKPKRKK
Site 25Y176TCKCQQEYFGERCGE
Site 26T188CGEKSMKTHSMIDSS
Site 27S190EKSMKTHSMIDSSLS
Site 28S194KTHSMIDSSLSKIAL
Site 29Y227TVQLRRQYVRKYEGE
Site 30Y231RRQYVRKYEGEAEER
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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