PhosphoNET

           
Protein Info 
   
Short Name:  E2A
Full Name:  Transcription factor E2-alpha
Alias:  BHLHb21; E12; E2A immunoglobulin enhancer-binding factor E12/E47; Immunoglobulin enhancer binding factor E12/E47; Immunoglobulin enhancer-binding factor E12,E47;Transcription factor 3;TCF-3;Immunoglobulin transcription factor 1;Transcription factor ITF-1;Kappa-E2-binding factor; Immunoglobulin transcription factor 1; Immunoglobulin transcription factor-1; ITF1; Kappa-E2-binding factor; MGC129647; MGC129648; TCF3; TCF-3; TFE2; Transcription factor 3; Transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47); Transcription factor ITF-1; Transcription factor-3; VDIR; VDR interacting repressor
Type:  Transcription protein
Mass (Da):  67600
Number AA:  654
UniProt ID:  P15923
International Prot ID:  IPI00013929
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005737  GO:0005634  GO:0043234 Uniprot OncoNet
Molecular Function:  GO:0043425  GO:0046982  GO:0042803 PhosphoSite+ KinaseNET
Biological Process:  GO:0002326  GO:0000080  GO:0030890 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S17VGTDKELSDLLDFSM
Site 2S23LSDLLDFSMMFPLPV
Site 3T31MMFPLPVTNGKGRPA
Site 4S39NGKGRPASLAGAQFG
Site 5S55SGLEDRPSSGSWGSG
Site 6S56GLEDRPSSGSWGSGD
Site 7S58EDRPSSGSWGSGDQS
Site 8S61PSSGSWGSGDQSSSS
Site 9S65SWGSGDQSSSSFDPS
Site 10S66WGSGDQSSSSFDPSR
Site 11S67GSGDQSSSSFDPSRT
Site 12S68SGDQSSSSFDPSRTF
Site 13S72SSSSFDPSRTFSEGT
Site 14T74SSFDPSRTFSEGTHF
Site 15S76FDPSRTFSEGTHFTE
Site 16T79SRTFSEGTHFTESHS
Site 17T82FSEGTHFTESHSSLS
Site 18S84EGTHFTESHSSLSSS
Site 19S86THFTESHSSLSSSTF
Site 20S87HFTESHSSLSSSTFL
Site 21S89TESHSSLSSSTFLGP
Site 22S90ESHSSLSSSTFLGPG
Site 23S91SHSSLSSSTFLGPGL
Site 24T92HSSLSSSTFLGPGLG
Site 25S102GPGLGGKSGERGAYA
Site 26Y108KSGERGAYASFGRDA
Site 27S110GERGAYASFGRDAGV
Site 28S134SGELALNSPGPLSPS
Site 29S139LNSPGPLSPSGMKGT
Site 30S141SPGPLSPSGMKGTSQ
Site 31T146SPSGMKGTSQYYPSY
Site 32S147PSGMKGTSQYYPSYS
Site 33Y149GMKGTSQYYPSYSGS
Site 34Y150MKGTSQYYPSYSGSS
Site 35S152GTSQYYPSYSGSSRR
Site 36Y153TSQYYPSYSGSSRRR
Site 37S154SQYYPSYSGSSRRRA
Site 38S156YYPSYSGSSRRRAAD
Site 39S157YPSYSGSSRRRAADG
Site 40S165RRRAADGSLDTQPKK
Site 41T168AADGSLDTQPKKVRK
Site 42S182KVPPGLPSSVYPPSS
Site 43S183VPPGLPSSVYPPSSG
Site 44Y185PGLPSSVYPPSSGED
Site 45S188PSSVYPPSSGEDYGR
Site 46S189SSVYPPSSGEDYGRD
Site 47Y193PPSSGEDYGRDATAY
Site 48T198EDYGRDATAYPSAKT
Site 49Y200YGRDATAYPSAKTPS
Site 50S202RDATAYPSAKTPSST
Site 51T205TAYPSAKTPSSTYPA
Site 52S208PSAKTPSSTYPAPFY
Site 53Y210AKTPSSTYPAPFYVA
Site 54Y215STYPAPFYVADGSLH
Site 55S220PFYVADGSLHPSAEL
Site 56S224ADGSLHPSAELWSPP
Site 57S229HPSAELWSPPGQAGF
Site 58S245PMLGGGSSPLPLPPG
Site 59S253PLPLPPGSGPVGSSG
Site 60S258PGSGPVGSSGSSSTF
Site 61S259GSGPVGSSGSSSTFG
Site 62S261GPVGSSGSSSTFGGL
Site 63S262PVGSSGSSSTFGGLH
Site 64S263VGSSGSSSTFGGLHQ
Site 65T264GSSGSSSTFGGLHQH
Site 66Y276HQHERMGYQLHGAEV
Site 67S289EVNGGLPSASSFSSA
Site 68S291NGGLPSASSFSSAPG
Site 69S292GGLPSASSFSSAPGA
Site 70S294LPSASSFSSAPGATY
Site 71S295PSASSFSSAPGATYG
Site 72Y301SSAPGATYGGVSSHT
Site 73S306ATYGGVSSHTPPVSG
Site 74T308YGGVSSHTPPVSGAD
Site 75S312SSHTPPVSGADSLLG
Site 76S316PPVSGADSLLGSRGT
Site 77S320GADSLLGSRGTTAGS
Site 78T323SLLGSRGTTAGSSGD
Site 79T324LLGSRGTTAGSSGDA
Site 80S327SRGTTAGSSGDALGK
Site 81S328RGTTAGSSGDALGKA
Site 82S338ALGKALASIYSPDHS
Site 83S341KALASIYSPDHSSNN
Site 84S345SIYSPDHSSNNFSSS
Site 85S346IYSPDHSSNNFSSSP
Site 86S350DHSSNNFSSSPSTPV
Site 87S351HSSNNFSSSPSTPVG
Site 88S352SSNNFSSSPSTPVGS
Site 89S354NNFSSSPSTPVGSPQ
Site 90T355NFSSSPSTPVGSPQG
Site 91S359SPSTPVGSPQGLAGT
Site 92T366SPQGLAGTSQWPRAG
Site 93S367PQGLAGTSQWPRAGA
Site 94S379AGAPGALSPSYDGGL
Site 95S381APGALSPSYDGGLHG
Site 96Y382PGALSPSYDGGLHGL
Site 97S391GGLHGLQSKIEDHLD
Site 98T417GTAGDMHTLLPGHGA
Site 99S427PGHGALASGFTGPMS
Site 100S434SGFTGPMSLGGRHAG
Site 101S455PEDGLAGSTSLMHNH
Site 102S457DGLAGSTSLMHNHAA
Site 103S467HNHAALPSQPGTLPD
Site 104T471ALPSQPGTLPDLSRP
Site 105S476PGTLPDLSRPPDSYS
Site 106S481DLSRPPDSYSGLGRA
Site 107Y482LSRPPDSYSGLGRAG
Site 108S483SRPPDSYSGLGRAGA
Site 109S509KEDEENTSAADHSEE
Site 110S514NTSAADHSEEEKKEL
Site 111T528LKAPRARTSPDEDED
Site 112S529KAPRARTSPDEDEDD
Site 113T587LNSEKPQTKLLILHQ
Site 114S627RREEEKVSGVVGDPQ
Site 115S638GDPQMVLSAPHPGLS
Site 116S645SAPHPGLSEAHNPAG
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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