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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DSP
Full Name:
Desmoplakin
Alias:
250/210 kDa paraneoplastic pemphigus antigen; DESP; DP; DPI; DPII; KPPS2; PPKS2
Type:
Cytoskeletal protein; Adhesion
Mass (Da):
331774
Number AA:
2871
UniProt ID:
P15924
International Prot ID:
IPI00013933
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0001533
GO:0005737
GO:0030057
Uniprot
OncoNet
Molecular Function:
GO:0030674
GO:0005200
PhosphoSite+
KinaseNET
Biological Process:
GO:0030216
GO:0018149
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S2
_
_
_
_
_
_
M
S
C
N
G
G
S
H
P
Site 2
S7
_
M
S
C
N
G
G
S
H
P
R
I
N
T
L
Site 3
T13
G
S
H
P
R
I
N
T
L
G
R
M
I
R
A
Site 4
S22
G
R
M
I
R
A
E
S
G
P
D
L
R
Y
E
Site 5
Y28
E
S
G
P
D
L
R
Y
E
V
T
S
G
G
G
Site 6
T31
P
D
L
R
Y
E
V
T
S
G
G
G
G
T
S
Site 7
S32
D
L
R
Y
E
V
T
S
G
G
G
G
T
S
R
Site 8
T37
V
T
S
G
G
G
G
T
S
R
M
Y
Y
S
R
Site 9
S38
T
S
G
G
G
G
T
S
R
M
Y
Y
S
R
R
Site 10
Y41
G
G
G
T
S
R
M
Y
Y
S
R
R
G
V
I
Site 11
Y42
G
G
T
S
R
M
Y
Y
S
R
R
G
V
I
T
Site 12
S43
G
T
S
R
M
Y
Y
S
R
R
G
V
I
T
D
Site 13
T49
Y
S
R
R
G
V
I
T
D
Q
N
S
D
G
Y
Site 14
S53
G
V
I
T
D
Q
N
S
D
G
Y
C
Q
T
G
Site 15
Y56
T
D
Q
N
S
D
G
Y
C
Q
T
G
T
M
S
Site 16
S79
Q
E
L
L
Q
N
C
S
D
C
L
M
R
A
E
Site 17
Y95
I
V
Q
P
E
L
K
Y
G
D
G
I
Q
L
T
Site 18
T102
Y
G
D
G
I
Q
L
T
R
S
R
E
L
D
E
Site 19
S104
D
G
I
Q
L
T
R
S
R
E
L
D
E
C
F
Site 20
S123
D
Q
M
E
I
L
D
S
L
I
R
E
M
R
Q
Site 21
Y138
M
G
Q
P
C
D
A
Y
Q
K
R
L
L
Q
L
Site 22
Y153
Q
E
Q
M
R
A
L
Y
K
A
I
S
V
P
R
Site 23
S157
R
A
L
Y
K
A
I
S
V
P
R
V
R
R
A
Site 24
S165
V
P
R
V
R
R
A
S
S
K
G
G
G
G
Y
Site 25
S166
P
R
V
R
R
A
S
S
K
G
G
G
G
Y
T
Site 26
Y172
S
S
K
G
G
G
G
Y
T
C
Q
S
G
S
G
Site 27
T173
S
K
G
G
G
G
Y
T
C
Q
S
G
S
G
W
Site 28
S176
G
G
G
Y
T
C
Q
S
G
S
G
W
D
E
F
Site 29
S178
G
Y
T
C
Q
S
G
S
G
W
D
E
F
T
K
Site 30
T184
G
S
G
W
D
E
F
T
K
H
V
T
S
E
C
Site 31
S213
A
W
G
V
D
L
A
S
V
E
Q
H
I
N
S
Site 32
S220
S
V
E
Q
H
I
N
S
H
R
G
I
H
N
S
Site 33
Y231
I
H
N
S
I
G
D
Y
R
W
Q
L
D
K
I
Site 34
S246
K
A
D
L
R
E
K
S
A
I
Y
Q
L
E
E
Site 35
Y249
L
R
E
K
S
A
I
Y
Q
L
E
E
E
Y
E
Site 36
Y255
I
Y
Q
L
E
E
E
Y
E
N
L
L
K
A
S
Site 37
S262
Y
E
N
L
L
K
A
S
F
E
R
M
D
H
L
Site 38
Y296
C
E
E
E
E
L
L
Y
D
W
S
D
K
N
T
Site 39
S299
E
E
L
L
Y
D
W
S
D
K
N
T
N
I
A
Site 40
S313
A
Q
K
Q
E
A
F
S
I
R
M
S
Q
L
E
Site 41
S317
E
A
F
S
I
R
M
S
Q
L
E
V
K
E
K
Site 42
S344
V
L
N
Q
H
P
A
S
D
K
I
E
A
Y
M
Site 43
Y378
H
L
K
E
N
A
A
Y
F
Q
F
F
E
E
A
Site 44
S387
Q
F
F
E
E
A
Q
S
T
E
A
Y
L
K
G
Site 45
T388
F
F
E
E
A
Q
S
T
E
A
Y
L
K
G
L
Site 46
Y391
E
A
Q
S
T
E
A
Y
L
K
G
L
Q
D
S
Site 47
S398
Y
L
K
G
L
Q
D
S
I
R
K
K
Y
P
C
Site 48
Y403
Q
D
S
I
R
K
K
Y
P
C
D
K
N
M
P
Site 49
Y431
E
R
E
K
I
L
E
Y
K
R
Q
V
Q
N
L
Site 50
S442
V
Q
N
L
V
N
K
S
K
K
I
V
Q
L
K
Site 51
Y455
L
K
P
R
N
P
D
Y
R
S
N
K
P
I
I
Site 52
S457
P
R
N
P
D
Y
R
S
N
K
P
I
I
L
R
Site 53
Y469
I
L
R
A
L
C
D
Y
K
Q
D
Q
K
I
V
Site 54
Y494
N
N
E
R
S
K
W
Y
V
T
G
P
G
G
V
Site 55
Y552
K
S
L
V
S
W
H
Y
C
M
I
D
I
E
K
Site 56
T570
M
T
I
A
K
L
K
T
M
R
Q
E
D
Y
M
Site 57
Y576
K
T
M
R
Q
E
D
Y
M
K
T
I
A
D
L
Site 58
S594
Y
Q
E
F
I
R
N
S
Q
G
S
E
M
F
G
Site 59
S597
F
I
R
N
S
Q
G
S
E
M
F
G
D
D
D
Site 60
S610
D
D
K
R
K
I
Q
S
Q
F
T
D
A
Q
K
Site 61
T613
R
K
I
Q
S
Q
F
T
D
A
Q
K
H
Y
Q
Site 62
Y629
L
V
I
Q
L
P
G
Y
P
Q
H
Q
T
V
T
Site 63
T634
P
G
Y
P
Q
H
Q
T
V
T
T
T
E
I
T
Site 64
T687
E
H
C
E
G
R
M
T
L
K
N
L
P
L
A
Site 65
S698
L
P
L
A
D
Q
G
S
S
H
H
I
T
V
K
Site 66
T703
Q
G
S
S
H
H
I
T
V
K
I
N
E
L
K
Site 67
S711
V
K
I
N
E
L
K
S
V
Q
N
D
S
Q
A
Site 68
S716
L
K
S
V
Q
N
D
S
Q
A
I
A
E
V
L
Site 69
Y739
N
F
R
G
S
E
K
Y
C
Y
L
Q
N
E
V
Site 70
Y741
R
G
S
E
K
Y
C
Y
L
Q
N
E
V
F
G
Site 71
Y787
T
E
D
M
L
K
V
Y
E
A
R
L
T
E
E
Site 72
T792
K
V
Y
E
A
R
L
T
E
E
E
T
V
C
L
Site 73
T796
A
R
L
T
E
E
E
T
V
C
L
D
L
D
K
Site 74
S823
N
D
L
N
L
K
K
S
L
L
A
T
M
K
T
Site 75
T827
L
K
K
S
L
L
A
T
M
K
T
E
L
Q
K
Site 76
T830
S
L
L
A
T
M
K
T
E
L
Q
K
A
Q
Q
Site 77
S840
Q
K
A
Q
Q
I
H
S
Q
T
S
Q
Q
Y
P
Site 78
S843
Q
Q
I
H
S
Q
T
S
Q
Q
Y
P
L
Y
D
Site 79
Y846
H
S
Q
T
S
Q
Q
Y
P
L
Y
D
L
D
L
Site 80
Y849
T
S
Q
Q
Y
P
L
Y
D
L
D
L
G
K
F
Site 81
T864
G
E
K
V
T
Q
L
T
D
R
W
Q
R
I
D
Site 82
Y891
Q
I
K
Q
L
R
N
Y
R
D
N
Y
Q
A
F
Site 83
Y895
L
R
N
Y
R
D
N
Y
Q
A
F
C
K
W
L
Site 84
Y903
Q
A
F
C
K
W
L
Y
D
A
K
R
R
Q
D
Site 85
S911
D
A
K
R
R
Q
D
S
L
E
S
M
K
F
G
Site 86
S914
R
R
Q
D
S
L
E
S
M
K
F
G
D
S
N
Site 87
T922
M
K
F
G
D
S
N
T
V
M
R
F
L
N
E
Site 88
S938
K
N
L
H
S
E
I
S
G
K
R
D
K
S
E
Site 89
S944
I
S
G
K
R
D
K
S
E
E
V
Q
K
I
A
Site 90
Y961
C
A
N
S
I
K
D
Y
E
L
Q
L
A
S
Y
Site 91
Y968
Y
E
L
Q
L
A
S
Y
T
S
G
L
E
T
L
Site 92
T983
L
N
I
P
I
K
R
T
M
I
Q
S
P
S
G
Site 93
Y1013
L
L
T
R
S
G
D
Y
Y
R
F
L
S
E
M
Site 94
Y1014
L
T
R
S
G
D
Y
Y
R
F
L
S
E
M
L
Site 95
S1018
G
D
Y
Y
R
F
L
S
E
M
L
K
S
L
E
Site 96
S1023
F
L
S
E
M
L
K
S
L
E
D
L
K
L
K
Site 97
S1049
R
L
A
R
D
A
N
S
E
N
C
N
K
N
K
Site 98
Y1065
L
D
Q
N
L
Q
K
Y
Q
A
E
C
S
Q
F
Site 99
S1070
Q
K
Y
Q
A
E
C
S
Q
F
K
A
K
L
A
Site 100
S1078
Q
F
K
A
K
L
A
S
L
E
E
L
K
R
Q
Site 101
Y1101
K
Q
N
L
D
K
C
Y
G
Q
I
K
E
L
N
Site 102
T1115
N
E
K
I
T
R
L
T
Y
E
I
E
D
E
K
Site 103
Y1116
E
K
I
T
R
L
T
Y
E
I
E
D
E
K
R
Site 104
S1127
D
E
K
R
R
R
K
S
V
E
D
R
F
D
Q
Site 105
Y1139
F
D
Q
Q
K
N
D
Y
D
Q
L
Q
K
A
R
Site 106
Y1169
K
A
I
K
E
K
E
Y
E
I
E
R
L
R
V
Site 107
T1183
V
L
L
Q
E
E
G
T
R
K
R
E
Y
E
N
Site 108
Y1188
E
G
T
R
K
R
E
Y
E
N
E
L
A
K
V
Site 109
Y1199
L
A
K
V
R
N
H
Y
N
E
E
M
S
N
L
Site 110
Y1210
M
S
N
L
R
N
K
Y
E
T
E
I
N
I
T
Site 111
T1212
N
L
R
N
K
Y
E
T
E
I
N
I
T
K
T
Site 112
T1219
T
E
I
N
I
T
K
T
T
I
K
E
I
S
M
Site 113
T1220
E
I
N
I
T
K
T
T
I
K
E
I
S
M
Q
Site 114
S1232
S
M
Q
K
E
D
D
S
K
N
L
R
N
Q
L
Site 115
S1243
R
N
Q
L
D
R
L
S
R
E
N
R
D
L
K
Site 116
T1319
S
L
E
E
A
A
K
T
I
Q
D
K
N
K
E
Site 117
Y1344
E
A
K
R
R
W
E
Y
E
N
E
L
S
K
V
Site 118
Y1355
L
S
K
V
R
N
N
Y
D
E
E
I
I
S
L
Site 119
S1361
N
Y
D
E
E
I
I
S
L
K
N
Q
F
E
T
Site 120
T1373
F
E
T
E
I
N
I
T
K
T
T
I
H
Q
L
Site 121
T1375
T
E
I
N
I
T
K
T
T
I
H
Q
L
T
M
Site 122
S1389
M
Q
K
E
E
D
T
S
G
Y
R
A
Q
I
D
Site 123
Y1391
K
E
E
D
T
S
G
Y
R
A
Q
I
D
N
L
Site 124
T1399
R
A
Q
I
D
N
L
T
R
E
N
R
S
L
S
Site 125
S1406
T
R
E
N
R
S
L
S
E
E
I
K
R
L
K
Site 126
T1415
E
I
K
R
L
K
N
T
L
T
Q
T
T
E
N
Site 127
T1417
K
R
L
K
N
T
L
T
Q
T
T
E
N
L
R
Site 128
T1420
K
N
T
L
T
Q
T
T
E
N
L
R
R
V
E
Site 129
S1438
Q
Q
Q
K
A
T
G
S
E
V
S
Q
R
K
Q
Site 130
S1441
K
A
T
G
S
E
V
S
Q
R
K
Q
Q
L
E
Site 131
T1455
E
V
E
L
R
Q
V
T
Q
M
R
T
E
E
S
Site 132
S1462
T
Q
M
R
T
E
E
S
V
R
Y
K
Q
S
L
Site 133
Y1465
R
T
E
E
S
V
R
Y
K
Q
S
L
D
D
A
Site 134
S1468
E
S
V
R
Y
K
Q
S
L
D
D
A
A
K
T
Site 135
T1494
K
Q
L
I
D
K
E
T
N
D
R
K
C
L
E
Site 136
Y1512
A
R
L
Q
R
V
Q
Y
D
L
Q
K
A
N
S
Site 137
S1519
Y
D
L
Q
K
A
N
S
S
A
T
E
T
I
N
Site 138
T1524
A
N
S
S
A
T
E
T
I
N
K
L
K
V
Q
Site 139
T1536
K
V
Q
E
Q
E
L
T
R
L
R
I
D
Y
E
Site 140
Y1542
L
T
R
L
R
I
D
Y
E
R
V
S
Q
E
R
Site 141
S1546
R
I
D
Y
E
R
V
S
Q
E
R
T
V
K
D
Site 142
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G
S
R
S
G
Site 294
S2827
S
S
A
P
G
S
R
S
G
S
R
S
G
S
R
Site 295
S2829
A
P
G
S
R
S
G
S
R
S
G
S
R
S
G
Site 296
S2831
G
S
R
S
G
S
R
S
G
S
R
S
G
S
R
Site 297
S2833
R
S
G
S
R
S
G
S
R
S
G
S
R
S
G
Site 298
S2841
R
S
G
S
R
S
G
S
R
S
G
S
R
R
G
Site 299
S2843
G
S
R
S
G
S
R
S
G
S
R
R
G
S
F
Site 300
S2845
R
S
G
S
R
S
G
S
R
R
G
S
F
D
A
Site 301
S2849
R
S
G
S
R
R
G
S
F
D
A
T
G
N
S
Site 302
T2853
R
R
G
S
F
D
A
T
G
N
S
S
Y
S
Y
Site 303
S2856
S
F
D
A
T
G
N
S
S
Y
S
Y
S
Y
S
Site 304
S2857
F
D
A
T
G
N
S
S
Y
S
Y
S
Y
S
F
Site 305
Y2858
D
A
T
G
N
S
S
Y
S
Y
S
Y
S
F
S
Site 306
S2859
A
T
G
N
S
S
Y
S
Y
S
Y
S
F
S
S
Site 307
Y2860
T
G
N
S
S
Y
S
Y
S
Y
S
F
S
S
S
Site 308
S2861
G
N
S
S
Y
S
Y
S
Y
S
F
S
S
S
S
Site 309
Y2862
N
S
S
Y
S
Y
S
Y
S
F
S
S
S
S
I
Site 310
S2863
S
S
Y
S
Y
S
Y
S
F
S
S
S
S
I
G
Site 311
S2865
Y
S
Y
S
Y
S
F
S
S
S
S
I
G
H
_
Site 312
S2866
S
Y
S
Y
S
F
S
S
S
S
I
G
H
_
_
Site 313
S2867
Y
S
Y
S
F
S
S
S
S
I
G
H
_
_
_
Site 314
S2868
S
Y
S
F
S
S
S
S
I
G
H
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation