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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
AGC1
Full Name:
Aggrecan core protein
Alias:
aggrecan; aggrecan core protein; aggrecan proteoglycan; cartilage-specific proteoglycan core protein; chondroitin sulfate proteoglycan core protein 1; CSPCP; CSPG1; CSPG1, PGCA; CSPGCP; MSK16; PGCA
Type:
Extracellular matrix
Mass (Da):
250190
Number AA:
UniProt ID:
P16112
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005578
Uniprot
OncoNet
Molecular Function:
GO:0005201
GO:0005540
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007155
GO:0006508
GO:0001501
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T19
R
V
I
T
A
A
V
T
V
E
T
S
D
H
D
Site 2
S23
A
A
V
T
V
E
T
S
D
H
D
N
S
L
S
Site 3
S28
E
T
S
D
H
D
N
S
L
S
V
S
I
P
Q
Site 4
S30
S
D
H
D
N
S
L
S
V
S
I
P
Q
P
S
Site 5
S32
H
D
N
S
L
S
V
S
I
P
Q
P
S
P
L
Site 6
T61
I
D
P
M
H
P
V
T
T
A
P
S
T
A
P
Site 7
S76
L
A
P
R
I
K
W
S
R
V
S
K
E
K
E
Site 8
S79
R
I
K
W
S
R
V
S
K
E
K
E
V
V
L
Site 9
S98
E
G
R
V
R
V
N
S
A
Y
Q
D
K
V
S
Site 10
Y100
R
V
R
V
N
S
A
Y
Q
D
K
V
S
L
P
Site 11
S105
S
A
Y
Q
D
K
V
S
L
P
N
Y
P
A
I
Site 12
Y109
D
K
V
S
L
P
N
Y
P
A
I
P
S
D
A
Site 13
S114
P
N
Y
P
A
I
P
S
D
A
T
L
E
V
Q
Site 14
T117
P
A
I
P
S
D
A
T
L
E
V
Q
S
L
R
Site 15
S122
D
A
T
L
E
V
Q
S
L
R
S
N
D
S
G
Site 16
S128
Q
S
L
R
S
N
D
S
G
V
Y
R
C
E
V
Site 17
Y131
R
S
N
D
S
G
V
Y
R
C
E
V
M
H
G
Site 18
T165
R
A
I
S
T
R
Y
T
L
D
F
D
R
A
Q
Site 19
T184
Q
N
S
A
I
I
A
T
P
E
Q
L
Q
A
A
Site 20
Y192
P
E
Q
L
Q
A
A
Y
E
D
G
F
H
Q
C
Site 21
T208
A
G
W
L
A
D
Q
T
V
R
Y
P
I
H
T
Site 22
Y211
L
A
D
Q
T
V
R
Y
P
I
H
T
P
R
E
Site 23
T215
T
V
R
Y
P
I
H
T
P
R
E
G
C
Y
G
Site 24
Y233
E
F
P
G
V
R
T
Y
G
I
R
D
T
N
E
Site 25
T238
R
T
Y
G
I
R
D
T
N
E
T
Y
D
V
Y
Site 26
Y245
T
N
E
T
Y
D
V
Y
C
F
A
E
E
M
E
Site 27
S260
G
E
V
F
Y
A
T
S
P
E
K
F
T
F
Q
Site 28
S306
A
G
W
L
A
D
R
S
V
R
Y
P
I
S
K
Site 29
Y309
L
A
D
R
S
V
R
Y
P
I
S
K
A
R
P
Site 30
S312
R
S
V
R
Y
P
I
S
K
A
R
P
N
C
G
Site 31
T335
V
Y
V
H
A
N
Q
T
G
Y
P
D
P
S
S
Site 32
Y337
V
H
A
N
Q
T
G
Y
P
D
P
S
S
R
Y
Site 33
S341
Q
T
G
Y
P
D
P
S
S
R
Y
D
A
I
C
Site 34
S342
T
G
Y
P
D
P
S
S
R
Y
D
A
I
C
Y
Site 35
T371
V
G
G
E
E
D
I
T
V
Q
T
V
T
W
P
Site 36
T389
L
P
L
P
R
N
I
T
E
G
E
A
R
G
S
Site 37
S396
T
E
G
E
A
R
G
S
V
I
L
T
V
K
P
Site 38
S408
V
K
P
I
F
E
V
S
P
S
P
L
E
P
E
Site 39
S410
P
I
F
E
V
S
P
S
P
L
E
P
E
E
P
Site 40
T419
L
E
P
E
E
P
F
T
F
A
P
E
I
G
A
Site 41
T447
T
R
P
W
G
F
P
T
P
G
L
G
P
A
T
Site 42
T454
T
P
G
L
G
P
A
T
A
F
T
S
E
D
L
Site 43
Y482
P
G
G
V
V
F
H
Y
R
P
G
P
T
R
Y
Site 44
S490
R
P
G
P
T
R
Y
S
L
T
F
E
E
A
Q
Site 45
T492
G
P
T
R
Y
S
L
T
F
E
E
A
Q
Q
A
Site 46
T533
A
G
W
L
R
D
Q
T
V
R
Y
P
I
V
S
Site 47
Y536
L
R
D
Q
T
V
R
Y
P
I
V
S
P
R
T
Site 48
S540
T
V
R
Y
P
I
V
S
P
R
T
P
C
V
G
Site 49
T543
Y
P
I
V
S
P
R
T
P
C
V
G
D
K
D
Site 50
S551
P
C
V
G
D
K
D
S
S
P
G
V
R
T
Y
Site 51
S552
C
V
G
D
K
D
S
S
P
G
V
R
T
Y
G
Site 52
T557
D
S
S
P
G
V
R
T
Y
G
V
R
P
S
T
Site 53
Y558
S
S
P
G
V
R
T
Y
G
V
R
P
S
T
E
Site 54
S563
R
T
Y
G
V
R
P
S
T
E
T
Y
D
V
Y
Site 55
T564
T
Y
G
V
R
P
S
T
E
T
Y
D
V
Y
C
Site 56
T566
G
V
R
P
S
T
E
T
Y
D
V
Y
C
F
V
Site 57
Y567
V
R
P
S
T
E
T
Y
D
V
Y
C
F
V
D
Site 58
Y570
S
T
E
T
Y
D
V
Y
C
F
V
D
R
L
E
Site 59
T590
A
T
R
L
E
Q
F
T
F
Q
E
A
L
E
F
Site 60
S600
E
A
L
E
F
C
E
S
H
N
A
T
A
T
T
Site 61
T604
F
C
E
S
H
N
A
T
A
T
T
G
Q
L
Y
Site 62
Y611
T
A
T
T
G
Q
L
Y
A
A
W
S
R
G
L
Site 63
Y622
S
R
G
L
D
K
C
Y
A
G
W
L
A
D
G
Site 64
Y633
L
A
D
G
S
L
R
Y
P
I
V
T
P
R
P
Site 65
T637
S
L
R
Y
P
I
V
T
P
R
P
A
C
G
G
Site 66
T651
G
D
K
P
G
V
R
T
V
Y
L
Y
P
N
Q
Site 67
Y653
K
P
G
V
R
T
V
Y
L
Y
P
N
Q
T
G
Site 68
Y655
G
V
R
T
V
Y
L
Y
P
N
Q
T
G
L
P
Site 69
T659
V
Y
L
Y
P
N
Q
T
G
L
P
D
P
L
S
Site 70
S666
T
G
L
P
D
P
L
S
R
H
H
A
F
C
F
Site 71
S681
R
G
I
S
A
V
P
S
P
G
E
E
E
G
G
Site 72
T689
P
G
E
E
E
G
G
T
P
T
S
P
S
G
V
Site 73
S692
E
E
G
G
T
P
T
S
P
S
G
V
E
E
W
Site 74
S694
G
G
T
P
T
S
P
S
G
V
E
E
W
I
V
Site 75
T718
V
P
V
E
E
E
T
T
A
V
P
S
G
E
T
Site 76
Y745
Q
T
E
W
E
P
A
Y
T
P
V
G
T
S
P
Site 77
T746
T
E
W
E
P
A
Y
T
P
V
G
T
S
P
L
Site 78
T759
P
L
P
G
I
L
P
T
W
P
P
T
G
A
E
Site 79
S770
T
G
A
E
T
E
E
S
T
E
G
P
S
A
T
Site 80
T777
S
T
E
G
P
S
A
T
E
V
P
S
A
S
E
Site 81
S781
P
S
A
T
E
V
P
S
A
S
E
E
P
S
P
Site 82
S783
A
T
E
V
P
S
A
S
E
E
P
S
P
S
E
Site 83
S787
P
S
A
S
E
E
P
S
P
S
E
V
P
F
P
Site 84
S789
A
S
E
E
P
S
P
S
E
V
P
F
P
S
E
Site 85
S795
P
S
E
V
P
F
P
S
E
E
P
S
P
S
E
Site 86
S799
P
F
P
S
E
E
P
S
P
S
E
E
P
F
P
Site 87
S801
P
S
E
E
P
S
P
S
E
E
P
F
P
S
V
Site 88
S807
P
S
E
E
P
F
P
S
V
R
P
F
P
S
V
Site 89
S813
P
S
V
R
P
F
P
S
V
E
L
F
P
S
E
Site 90
S819
P
S
V
E
L
F
P
S
E
E
P
F
P
S
K
Site 91
S825
P
S
E
E
P
F
P
S
K
E
P
S
P
S
E
Site 92
S829
P
F
P
S
K
E
P
S
P
S
E
E
P
S
A
Site 93
S831
P
S
K
E
P
S
P
S
E
E
P
S
A
S
E
Site 94
S835
P
S
P
S
E
E
P
S
A
S
E
E
P
Y
T
Site 95
S837
P
S
E
E
P
S
A
S
E
E
P
Y
T
P
S
Site 96
Y841
P
S
A
S
E
E
P
Y
T
P
S
P
P
E
P
Site 97
T842
S
A
S
E
E
P
Y
T
P
S
P
P
E
P
S
Site 98
S844
S
E
E
P
Y
T
P
S
P
P
E
P
S
W
T
Site 99
S849
T
P
S
P
P
E
P
S
W
T
E
L
P
S
S
Site 100
T851
S
P
P
E
P
S
W
T
E
L
P
S
S
G
E
Site 101
S855
P
S
W
T
E
L
P
S
S
G
E
E
S
G
A
Site 102
S856
S
W
T
E
L
P
S
S
G
E
E
S
G
A
P
Site 103
S860
L
P
S
S
G
E
E
S
G
A
P
D
V
S
G
Site 104
S866
E
S
G
A
P
D
V
S
G
D
F
T
G
S
G
Site 105
T870
P
D
V
S
G
D
F
T
G
S
G
D
V
S
G
Site 106
S872
V
S
G
D
F
T
G
S
G
D
V
S
G
H
L
Site 107
S876
F
T
G
S
G
D
V
S
G
H
L
D
F
S
G
Site 108
S882
V
S
G
H
L
D
F
S
G
Q
L
S
G
D
R
Site 109
S886
L
D
F
S
G
Q
L
S
G
D
R
A
S
G
L
Site 110
S891
Q
L
S
G
D
R
A
S
G
L
P
S
G
D
L
Site 111
S895
D
R
A
S
G
L
P
S
G
D
L
D
S
S
G
Site 112
S900
L
P
S
G
D
L
D
S
S
G
L
T
S
T
V
Site 113
S901
P
S
G
D
L
D
S
S
G
L
T
S
T
V
G
Site 114
T904
D
L
D
S
S
G
L
T
S
T
V
G
S
G
L
Site 115
S915
G
S
G
L
T
V
E
S
G
L
P
S
G
D
E
Site 116
S919
T
V
E
S
G
L
P
S
G
D
E
E
R
I
E
Site 117
S929
E
E
R
I
E
W
P
S
T
P
T
V
G
E
L
Site 118
T930
E
R
I
E
W
P
S
T
P
T
V
G
E
L
P
Site 119
T932
I
E
W
P
S
T
P
T
V
G
E
L
P
S
G
Site 120
S958
G
D
L
S
G
L
P
S
G
E
V
L
E
T
S
Site 121
T964
P
S
G
E
V
L
E
T
S
A
S
G
V
G
D
Site 122
S977
G
D
L
S
G
L
P
S
G
E
V
L
E
T
T
Site 123
T983
P
S
G
E
V
L
E
T
T
A
P
G
V
E
D
Site 124
S996
E
D
I
S
G
L
P
S
G
E
V
L
E
T
T
Site 125
S1072
E
D
I
S
G
L
P
S
G
E
V
L
E
T
A
Site 126
T1078
P
S
G
E
V
L
E
T
A
A
P
G
V
E
D
Site 127
T1287
P
S
G
E
V
L
E
T
T
A
P
G
V
E
E
Site 128
S1296
A
P
G
V
E
E
I
S
G
L
P
S
G
E
V
Site 129
S1300
E
E
I
S
G
L
P
S
G
E
V
L
E
T
T
Site 130
T1306
P
S
G
E
V
L
E
T
T
A
P
G
V
D
E
Site 131
S1315
A
P
G
V
D
E
I
S
G
L
P
S
G
E
V
Site 132
S1319
D
E
I
S
G
L
P
S
G
E
V
L
E
T
T
Site 133
S1338
E
E
I
S
G
L
P
S
G
E
V
L
E
T
S
Site 134
T1344
P
S
G
E
V
L
E
T
S
T
S
A
V
G
D
Site 135
S1345
S
G
E
V
L
E
T
S
T
S
A
V
G
D
L
Site 136
S1347
E
V
L
E
T
S
T
S
A
V
G
D
L
S
G
Site 137
S1353
T
S
A
V
G
D
L
S
G
L
P
S
G
G
E
Site 138
S1377
E
D
I
S
G
L
P
S
G
E
V
V
E
T
S
Site 139
T1383
P
S
G
E
V
V
E
T
S
A
S
G
I
E
D
Site 140
S1386
E
V
V
E
T
S
A
S
G
I
E
D
V
S
E
Site 141
S1392
A
S
G
I
E
D
V
S
E
L
P
S
G
E
G
Site 142
S1396
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R
R
Site 294
S2238
R
R
C
R
E
Q
Q
S
H
L
S
S
I
V
T
Site 295
S2242
E
Q
Q
S
H
L
S
S
I
V
T
P
E
E
Q
Site 296
T2245
S
H
L
S
S
I
V
T
P
E
E
Q
E
F
V
Site 297
Y2259
V
N
N
N
A
Q
D
Y
Q
W
I
G
L
N
D
Site 298
T2329
P
F
T
C
K
K
G
T
V
A
C
G
E
P
P
Site 299
T2343
P
V
V
E
H
A
R
T
F
G
Q
K
K
D
R
Site 300
Y2351
F
G
Q
K
K
D
R
Y
E
I
N
S
L
V
R
Site 301
Y2359
E
I
N
S
L
V
R
Y
Q
C
T
E
G
F
V
Site 302
T2372
F
V
Q
R
H
M
P
T
I
R
C
Q
P
S
G
Site 303
T2392
R
I
T
C
T
D
A
T
T
Y
K
R
R
L
Q
Site 304
T2393
I
T
C
T
D
A
T
T
Y
K
R
R
L
Q
K
Site 305
Y2394
T
C
T
D
A
T
T
Y
K
R
R
L
Q
K
R
Site 306
S2402
K
R
R
L
Q
K
R
S
S
R
H
P
R
R
S
Site 307
S2403
R
R
L
Q
K
R
S
S
R
H
P
R
R
S
R
Site 308
S2409
S
S
R
H
P
R
R
S
R
P
S
T
A
H
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation