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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PFKB1
Full Name:
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
Alias:
6PF-2-K/Fru-2,6-P2ase liver isozyme
Type:
Enzyme, cellular metabolism, kinase
Mass (Da):
54681
Number AA:
471
UniProt ID:
P16118
International Prot ID:
IPI00783603
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0043540
Uniprot
OncoNet
Molecular Function:
GO:0003873
GO:0005524
GO:0004331
PhosphoSite+
KinaseNET
Biological Process:
GO:0006003
GO:0006094
GO:0006096
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S2
_
_
_
_
_
_
M
S
P
E
M
G
E
L
T
Site 2
T9
S
P
E
M
G
E
L
T
Q
T
R
L
Q
K
I
Site 3
T11
E
M
G
E
L
T
Q
T
R
L
Q
K
I
W
I
Site 4
S21
Q
K
I
W
I
P
H
S
S
G
S
S
R
L
Q
Site 5
S22
K
I
W
I
P
H
S
S
G
S
S
R
L
Q
R
Site 6
S24
W
I
P
H
S
S
G
S
S
R
L
Q
R
R
R
Site 7
S25
I
P
H
S
S
G
S
S
R
L
Q
R
R
R
G
Site 8
S33
R
L
Q
R
R
R
G
S
S
I
P
Q
F
T
N
Site 9
S34
L
Q
R
R
R
G
S
S
I
P
Q
F
T
N
S
Site 10
T56
G
L
P
A
R
G
K
T
Y
I
S
T
K
L
T
Site 11
S59
A
R
G
K
T
Y
I
S
T
K
L
T
R
Y
L
Site 12
Y65
I
S
T
K
L
T
R
Y
L
N
W
I
G
T
P
Site 13
T71
R
Y
L
N
W
I
G
T
P
T
K
V
F
N
L
Site 14
Y81
K
V
F
N
L
G
Q
Y
R
R
E
A
V
S
Y
Site 15
Y88
Y
R
R
E
A
V
S
Y
K
N
Y
E
F
F
L
Site 16
Y91
E
A
V
S
Y
K
N
Y
E
F
F
L
P
D
N
Site 17
Y119
A
L
K
D
V
H
N
Y
L
S
H
E
E
G
H
Site 18
S121
K
D
V
H
N
Y
L
S
H
E
E
G
H
V
A
Site 19
T135
A
V
F
D
A
T
N
T
T
R
E
R
R
S
L
Site 20
S141
N
T
T
R
E
R
R
S
L
I
L
Q
F
A
K
Site 21
S178
I
R
Q
V
K
L
G
S
P
D
Y
I
D
C
D
Site 22
Y181
V
K
L
G
S
P
D
Y
I
D
C
D
R
E
K
Site 23
Y200
F
L
K
R
I
E
C
Y
E
V
N
Y
Q
P
L
Site 24
S213
P
L
D
E
E
L
D
S
H
L
S
Y
I
K
I
Site 25
S216
E
E
L
D
S
H
L
S
Y
I
K
I
F
D
V
Site 26
Y227
I
F
D
V
G
T
R
Y
M
V
N
R
V
Q
D
Site 27
Y242
H
I
Q
S
R
T
V
Y
Y
L
M
N
I
H
V
Site 28
Y243
I
Q
S
R
T
V
Y
Y
L
M
N
I
H
V
T
Site 29
Y255
H
V
T
P
R
S
I
Y
L
C
R
H
G
E
S
Site 30
S274
R
G
R
I
G
G
D
S
G
L
S
V
R
G
K
Site 31
S277
I
G
G
D
S
G
L
S
V
R
G
K
Q
Y
A
Site 32
S297
F
I
Q
S
Q
G
I
S
S
L
K
V
W
T
S
Site 33
S298
I
Q
S
Q
G
I
S
S
L
K
V
W
T
S
H
Site 34
S304
S
S
L
K
V
W
T
S
H
M
K
R
T
I
Q
Site 35
Y339
G
V
C
E
E
M
T
Y
E
E
I
Q
E
H
Y
Site 36
Y346
Y
E
E
I
Q
E
H
Y
P
E
E
F
A
L
R
Site 37
Y358
A
L
R
D
Q
D
K
Y
R
Y
R
Y
P
K
G
Site 38
Y360
R
D
Q
D
K
Y
R
Y
R
Y
P
K
G
E
S
Site 39
Y362
Q
D
K
Y
R
Y
R
Y
P
K
G
E
S
Y
E
Site 40
S408
L
A
Y
F
L
D
K
S
S
D
E
L
P
Y
L
Site 41
S409
A
Y
F
L
D
K
S
S
D
E
L
P
Y
L
K
Site 42
Y414
K
S
S
D
E
L
P
Y
L
K
C
P
L
H
T
Site 43
T446
L
N
V
E
A
V
N
T
H
R
E
K
P
E
N
Site 44
T457
K
P
E
N
V
D
I
T
R
E
P
E
E
A
L
Site 45
T466
E
P
E
E
A
L
D
T
V
P
A
H
Y
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation