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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ITGB4
Full Name:
Integrin beta-4
Alias:
CD104; CD104 antigen; GP150; Integrin beta-4; Integrin beta-4C; Integrin, beta 4; ITB4
Type:
Receptor, misc.; Adhesion
Mass (Da):
202151
Number AA:
1822
UniProt ID:
P16144
International Prot ID:
IPI00220845
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0008305
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0004872
PhosphoSite+
KinaseNET
Biological Process:
GO:0007160
GO:0007229
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
A
G
P
R
P
S
P
W
A
R
L
L
L
Site 2
S21
L
A
A
L
I
S
V
S
L
S
G
T
L
A
N
Site 3
T25
I
S
V
S
L
S
G
T
L
A
N
R
C
K
K
Site 4
Y50
R
V
D
K
D
C
A
Y
C
T
D
E
M
F
R
Site 5
S368
E
A
F
N
R
I
R
S
N
L
D
I
R
A
L
Site 6
S377
L
D
I
R
A
L
D
S
P
R
G
L
R
T
E
Site 7
T383
D
S
P
R
G
L
R
T
E
V
T
S
K
M
F
Site 8
S387
G
L
R
T
E
V
T
S
K
M
F
Q
K
T
R
Site 9
T681
R
D
E
D
D
D
C
T
Y
S
Y
T
M
E
G
Site 10
Y762
V
G
F
K
E
D
H
Y
M
L
R
E
N
L
M
Site 11
T776
M
A
S
D
H
L
D
T
P
M
L
R
S
G
N
Site 12
T805
M
Q
R
P
G
F
A
T
H
A
A
S
I
N
P
Site 13
S821
E
L
V
P
Y
G
L
S
L
R
L
A
R
L
C
Site 14
T829
L
R
L
A
R
L
C
T
E
N
L
L
K
P
D
Site 15
T837
E
N
L
L
K
P
D
T
R
E
C
A
Q
L
R
Site 16
Y855
E
E
N
L
N
E
V
Y
R
Q
I
S
G
V
H
Site 17
S859
N
E
V
Y
R
Q
I
S
G
V
H
K
L
Q
Q
Site 18
T882
A
G
K
K
Q
D
H
T
I
V
D
T
V
L
M
Site 19
T886
Q
D
H
T
I
V
D
T
V
L
M
A
P
R
S
Site 20
Y920
D
L
K
V
A
P
G
Y
Y
T
L
T
A
D
Q
Site 21
Y921
L
K
V
A
P
G
Y
Y
T
L
T
A
D
Q
D
Site 22
T973
D
V
P
A
G
T
A
T
L
G
R
R
L
V
N
Site 23
T982
G
R
R
L
V
N
I
T
I
I
K
E
Q
A
R
Site 24
S993
E
Q
A
R
D
V
V
S
F
E
Q
P
E
F
S
Site 25
S1000
S
F
E
Q
P
E
F
S
V
S
R
G
D
Q
V
Site 26
S1002
E
Q
P
E
F
S
V
S
R
G
D
Q
V
A
R
Site 27
S1022
R
V
L
D
G
G
K
S
Q
V
S
Y
R
T
Q
Site 28
S1025
D
G
G
K
S
Q
V
S
Y
R
T
Q
D
G
T
Site 29
Y1026
G
G
K
S
Q
V
S
Y
R
T
Q
D
G
T
A
Site 30
T1032
S
Y
R
T
Q
D
G
T
A
Q
G
N
R
D
Y
Site 31
Y1039
T
A
Q
G
N
R
D
Y
I
P
V
E
G
E
L
Site 32
S1069
L
E
L
Q
E
V
D
S
L
L
R
G
R
Q
V
Site 33
S1084
R
R
F
H
V
Q
L
S
N
P
K
F
G
A
H
Site 34
S1097
A
H
L
G
Q
P
H
S
T
T
I
I
I
R
D
Site 35
T1098
H
L
G
Q
P
H
S
T
T
I
I
I
R
D
P
Site 36
T1099
L
G
Q
P
H
S
T
T
I
I
I
R
D
P
D
Site 37
S1111
D
P
D
E
L
D
R
S
F
T
S
Q
M
L
S
Site 38
T1113
D
E
L
D
R
S
F
T
S
Q
M
L
S
S
Q
Site 39
S1114
E
L
D
R
S
F
T
S
Q
M
L
S
S
Q
P
Site 40
S1118
S
F
T
S
Q
M
L
S
S
Q
P
P
P
H
G
Site 41
S1119
F
T
S
Q
M
L
S
S
Q
P
P
P
H
G
D
Site 42
Y1157
P
S
G
K
P
M
G
Y
R
V
K
Y
W
I
Q
Site 43
Y1161
P
M
G
Y
R
V
K
Y
W
I
Q
G
D
S
E
Site 44
S1169
W
I
Q
G
D
S
E
S
E
A
H
L
L
D
S
Site 45
S1176
S
E
A
H
L
L
D
S
K
V
P
S
V
E
L
Site 46
T1184
K
V
P
S
V
E
L
T
N
L
Y
P
Y
C
D
Site 47
Y1187
S
V
E
L
T
N
L
Y
P
Y
C
D
Y
E
M
Site 48
Y1189
E
L
T
N
L
Y
P
Y
C
D
Y
E
M
K
V
Site 49
Y1192
N
L
Y
P
Y
C
D
Y
E
M
K
V
C
A
Y
Site 50
Y1199
Y
E
M
K
V
C
A
Y
G
A
Q
G
E
G
P
Site 51
Y1207
G
A
Q
G
E
G
P
Y
S
S
L
V
S
C
R
Site 52
S1208
A
Q
G
E
G
P
Y
S
S
L
V
S
C
R
T
Site 53
S1209
Q
G
E
G
P
Y
S
S
L
V
S
C
R
T
H
Site 54
S1212
G
P
Y
S
S
L
V
S
C
R
T
H
Q
E
V
Site 55
T1215
S
S
L
V
S
C
R
T
H
Q
E
V
P
S
E
Site 56
S1221
R
T
H
Q
E
V
P
S
E
P
G
R
L
A
F
Site 57
T1236
N
V
V
S
S
T
V
T
Q
L
S
W
A
E
P
Site 58
S1239
S
S
T
V
T
Q
L
S
W
A
E
P
A
E
T
Site 59
T1246
S
W
A
E
P
A
E
T
N
G
E
I
T
A
Y
Site 60
Y1257
I
T
A
Y
E
V
C
Y
G
L
V
N
D
D
N
Site 61
S1291
L
I
E
N
L
R
E
S
Q
P
Y
R
Y
T
V
Site 62
Y1294
N
L
R
E
S
Q
P
Y
R
Y
T
V
K
A
R
Site 63
T1297
E
S
Q
P
Y
R
Y
T
V
K
A
R
N
G
A
Site 64
T1318
E
A
I
I
N
L
A
T
Q
P
K
R
P
M
S
Site 65
S1325
T
Q
P
K
R
P
M
S
I
P
I
I
P
D
I
Site 66
S1339
I
P
I
V
D
A
Q
S
G
E
D
Y
D
S
F
Site 67
Y1343
D
A
Q
S
G
E
D
Y
D
S
F
L
M
Y
S
Site 68
S1345
Q
S
G
E
D
Y
D
S
F
L
M
Y
S
D
D
Site 69
Y1349
D
Y
D
S
F
L
M
Y
S
D
D
V
L
R
S
Site 70
S1350
Y
D
S
F
L
M
Y
S
D
D
V
L
R
S
P
Site 71
S1356
Y
S
D
D
V
L
R
S
P
S
G
S
Q
R
P
Site 72
S1358
D
D
V
L
R
S
P
S
G
S
Q
R
P
S
V
Site 73
S1360
V
L
R
S
P
S
G
S
Q
R
P
S
V
S
D
Site 74
S1364
P
S
G
S
Q
R
P
S
V
S
D
D
T
G
C
Site 75
S1366
G
S
Q
R
P
S
V
S
D
D
T
G
C
G
W
Site 76
T1369
R
P
S
V
S
D
D
T
G
C
G
W
K
F
E
Site 77
T1389
E
L
D
L
R
R
V
T
W
R
L
P
P
E
L
Site 78
S1401
P
E
L
I
P
R
L
S
A
S
S
G
R
S
S
Site 79
S1403
L
I
P
R
L
S
A
S
S
G
R
S
S
D
A
Site 80
S1404
I
P
R
L
S
A
S
S
G
R
S
S
D
A
E
Site 81
S1407
L
S
A
S
S
G
R
S
S
D
A
E
A
P
H
Site 82
S1408
S
A
S
S
G
R
S
S
D
A
E
A
P
H
G
Site 83
S1428
G
A
G
G
K
G
G
S
L
P
R
S
A
T
P
Site 84
S1432
K
G
G
S
L
P
R
S
A
T
P
G
P
P
G
Site 85
T1434
G
S
L
P
R
S
A
T
P
G
P
P
G
E
H
Site 86
S1454
M
D
F
A
F
P
G
S
T
N
S
L
H
R
M
Site 87
T1455
D
F
A
F
P
G
S
T
N
S
L
H
R
M
T
Site 88
S1457
A
F
P
G
S
T
N
S
L
H
R
M
T
T
T
Site 89
T1462
T
N
S
L
H
R
M
T
T
T
S
A
A
A
Y
Site 90
T1463
N
S
L
H
R
M
T
T
T
S
A
A
A
Y
G
Site 91
S1465
L
H
R
M
T
T
T
S
A
A
A
Y
G
T
H
Site 92
Y1469
T
T
T
S
A
A
A
Y
G
T
H
L
S
P
H
Site 93
T1471
T
S
A
A
A
Y
G
T
H
L
S
P
H
V
P
Site 94
S1474
A
A
Y
G
T
H
L
S
P
H
V
P
H
R
V
Site 95
S1483
H
V
P
H
R
V
L
S
T
S
S
T
L
T
R
Site 96
T1484
V
P
H
R
V
L
S
T
S
S
T
L
T
R
D
Site 97
S1485
P
H
R
V
L
S
T
S
S
T
L
T
R
D
Y
Site 98
S1486
H
R
V
L
S
T
S
S
T
L
T
R
D
Y
N
Site 99
T1487
R
V
L
S
T
S
S
T
L
T
R
D
Y
N
S
Site 100
T1489
L
S
T
S
S
T
L
T
R
D
Y
N
S
L
T
Site 101
Y1492
S
S
T
L
T
R
D
Y
N
S
L
T
R
S
E
Site 102
S1494
T
L
T
R
D
Y
N
S
L
T
R
S
E
H
S
Site 103
T1496
T
R
D
Y
N
S
L
T
R
S
E
H
S
H
S
Site 104
S1498
D
Y
N
S
L
T
R
S
E
H
S
H
S
T
T
Site 105
S1501
S
L
T
R
S
E
H
S
H
S
T
T
L
P
R
Site 106
S1503
T
R
S
E
H
S
H
S
T
T
L
P
R
D
Y
Site 107
T1504
R
S
E
H
S
H
S
T
T
L
P
R
D
Y
S
Site 108
T1505
S
E
H
S
H
S
T
T
L
P
R
D
Y
S
T
Site 109
Y1510
S
T
T
L
P
R
D
Y
S
T
L
T
S
V
S
Site 110
S1511
T
T
L
P
R
D
Y
S
T
L
T
S
V
S
S
Site 111
T1512
T
L
P
R
D
Y
S
T
L
T
S
V
S
S
H
Site 112
T1514
P
R
D
Y
S
T
L
T
S
V
S
S
H
D
S
Site 113
S1515
R
D
Y
S
T
L
T
S
V
S
S
H
D
S
R
Site 114
S1517
Y
S
T
L
T
S
V
S
S
H
D
S
R
L
T
Site 115
S1518
S
T
L
T
S
V
S
S
H
D
S
R
L
T
A
Site 116
S1521
T
S
V
S
S
H
D
S
R
L
T
A
G
V
P
Site 117
T1524
S
S
H
D
S
R
L
T
A
G
V
P
D
T
P
Site 118
T1530
L
T
A
G
V
P
D
T
P
T
R
L
V
F
S
Site 119
S1543
F
S
A
L
G
P
T
S
L
R
V
S
W
Q
E
Site 120
S1547
G
P
T
S
L
R
V
S
W
Q
E
P
R
C
E
Site 121
Y1560
C
E
R
P
L
Q
G
Y
S
V
E
Y
Q
L
L
Site 122
S1561
E
R
P
L
Q
G
Y
S
V
E
Y
Q
L
L
N
Site 123
Y1564
L
Q
G
Y
S
V
E
Y
Q
L
L
N
G
G
E
Site 124
S1595
E
D
L
L
P
N
H
S
Y
V
F
R
V
R
A
Site 125
Y1596
D
L
L
P
N
H
S
Y
V
F
R
V
R
A
Q
Site 126
S1604
V
F
R
V
R
A
Q
S
Q
E
G
W
G
R
E
Site 127
T1617
R
E
R
E
G
V
I
T
I
E
S
Q
V
H
P
Site 128
S1620
E
G
V
I
T
I
E
S
Q
V
H
P
Q
S
P
Site 129
S1626
E
S
Q
V
H
P
Q
S
P
L
C
P
L
P
G
Site 130
S1639
P
G
S
A
F
T
L
S
T
P
S
A
P
G
P
Site 131
S1653
P
L
V
F
T
A
L
S
P
D
S
L
Q
L
S
Site 132
S1656
F
T
A
L
S
P
D
S
L
Q
L
S
W
E
R
Site 133
S1660
S
P
D
S
L
Q
L
S
W
E
R
P
R
R
P
Site 134
Y1674
P
N
G
D
I
V
G
Y
L
V
T
C
E
M
A
Site 135
T1688
A
Q
G
G
G
P
A
T
A
F
R
V
D
G
D
Site 136
S1696
A
F
R
V
D
G
D
S
P
E
S
R
L
T
V
Site 137
S1699
V
D
G
D
S
P
E
S
R
L
T
V
P
G
L
Site 138
T1702
D
S
P
E
S
R
L
T
V
P
G
L
S
E
N
Site 139
S1707
R
L
T
V
P
G
L
S
E
N
V
P
Y
K
F
Site 140
Y1712
G
L
S
E
N
V
P
Y
K
F
K
V
Q
A
R
Site 141
T1721
F
K
V
Q
A
R
T
T
E
G
F
G
P
E
R
Site 142
T1733
P
E
R
E
G
I
I
T
I
E
S
Q
D
G
G
Site 143
S1736
E
G
I
I
T
I
E
S
Q
D
G
G
P
F
P
Site 144
S1758
L
F
Q
H
P
L
Q
S
E
Y
S
S
I
T
T
Site 145
Y1760
Q
H
P
L
Q
S
E
Y
S
S
I
T
T
T
H
Site 146
S1761
H
P
L
Q
S
E
Y
S
S
I
T
T
T
H
T
Site 147
S1762
P
L
Q
S
E
Y
S
S
I
T
T
T
H
T
S
Site 148
T1765
S
E
Y
S
S
I
T
T
T
H
T
S
A
T
E
Site 149
T1766
E
Y
S
S
I
T
T
T
H
T
S
A
T
E
P
Site 150
T1771
T
T
T
H
T
S
A
T
E
P
F
L
V
D
G
Site 151
S1791
Q
H
L
E
A
G
G
S
L
T
R
H
V
T
Q
Site 152
T1793
L
E
A
G
G
S
L
T
R
H
V
T
Q
E
F
Site 153
T1797
G
S
L
T
R
H
V
T
Q
E
F
V
S
R
T
Site 154
T1804
T
Q
E
F
V
S
R
T
L
T
T
S
G
T
L
Site 155
T1806
E
F
V
S
R
T
L
T
T
S
G
T
L
S
T
Site 156
T1807
F
V
S
R
T
L
T
T
S
G
T
L
S
T
H
Site 157
S1808
V
S
R
T
L
T
T
S
G
T
L
S
T
H
M
Site 158
T1810
R
T
L
T
T
S
G
T
L
S
T
H
M
D
Q
Site 159
S1812
L
T
T
S
G
T
L
S
T
H
M
D
Q
Q
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation