KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
CBR1
Full Name:
Carbonyl reductase [NADPH] 1
Alias:
15-hydroxyprostaglandin dehydrogenase [NADP+]; 2; 9-reductase; Carbonyl reductase (NADPH); Carbonyl reductase (NADPH) 1; Carbonyl reductase 1; CBR; CRN; DHCA; EC 1.1.1.184; EC 1.1.1.189; EC 1.1.1.197; HCBR1; NADPH-dependent carbonyl reductase 1; Prostaglandin 9-ketoreductase; Prostaglandin-E; Prostaglandin-E(2) 9-reductase; SDR21C1; Short chain dehydrogenase/reductase family 21C, member 1
Type:
EC 1.1.1.184; Oxidoreductase; EC 1.1.1.197; Lipid Metabolism - arachidonic acid; EC 1.1.1.189
Mass (Da):
30375
Number AA:
277
UniProt ID:
P16152
International Prot ID:
IPI00295386
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0047021
GO:0004090
GO:0050221
PhosphoSite+
KinaseNET
Biological Process:
GO:0017144
GO:0055114
GO:0042373
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S2
_
_
_
_
_
_
M
S
S
G
I
H
V
A
L
Site 2
S30
R
D
L
C
R
L
F
S
G
D
V
V
L
T
A
Site 3
T41
V
L
T
A
R
D
V
T
R
G
Q
A
A
V
Q
Site 4
S56
Q
L
Q
A
E
G
L
S
P
R
F
H
Q
L
D
Site 5
S69
L
D
I
D
D
L
Q
S
I
R
A
L
R
D
F
Site 6
Y81
R
D
F
L
R
K
E
Y
G
G
L
D
V
L
V
Site 7
T101
A
F
K
V
A
D
P
T
P
F
H
I
Q
A
E
Site 8
S149
M
S
V
R
A
L
K
S
C
S
P
E
L
Q
Q
Site 9
S151
V
R
A
L
K
S
C
S
P
E
L
Q
Q
K
F
Site 10
S160
E
L
Q
Q
K
F
R
S
E
T
I
T
E
E
E
Site 11
T162
Q
Q
K
F
R
S
E
T
I
T
E
E
E
L
V
Site 12
T164
K
F
R
S
E
T
I
T
E
E
E
L
V
G
L
Site 13
S191
H
Q
K
E
G
W
P
S
S
A
Y
G
V
T
K
Site 14
S192
Q
K
E
G
W
P
S
S
A
Y
G
V
T
K
I
Site 15
Y194
E
G
W
P
S
S
A
Y
G
V
T
K
I
G
V
Site 16
S205
K
I
G
V
T
V
L
S
R
I
H
A
R
K
L
Site 17
S213
R
I
H
A
R
K
L
S
E
Q
R
K
G
D
K
Site 18
S243
A
G
P
K
A
T
K
S
P
E
E
G
A
E
T
Site 19
Y253
E
G
A
E
T
P
V
Y
L
A
L
L
P
P
D
Site 20
S270
G
P
H
G
Q
F
V
S
E
K
R
V
E
Q
W
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation