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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ANK1
Full Name:
Ankyrin-1
Alias:
ANK; Ankyrin 1; Ankyrin 1, erythrocytic; Ankyrin R; Ankyrin-R; Erythrocyte ankyrin; SPH1
Type:
Adapter/scaffold protein
Mass (Da):
206265
Number AA:
1881
UniProt ID:
P16157
International Prot ID:
IPI00216697
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0031430
GO:0016323
GO:0016529
Uniprot
OncoNet
Molecular Function:
GO:0008093
GO:0019899
GO:0030507
PhosphoSite+
KinaseNET
Biological Process:
GO:0007010
GO:0006887
GO:0045199
Phosida
TranscriptoNet
STRING
Kinexus Products
Ankyrin-1 pan-specific antibody AB-NN195-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN195-1#Ankyrin-1 pan-specific antibody AB-NN195-2#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN195-2
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y3
_
_
_
_
_
_
P
Y
S
V
G
F
R
E
A
Site 2
S15
R
E
A
D
A
A
T
S
F
L
R
A
A
R
S
Site 3
S22
S
F
L
R
A
A
R
S
G
N
L
D
K
A
L
Site 4
Y100
V
V
R
E
L
V
N
Y
G
A
N
V
N
A
Q
Site 5
S108
G
A
N
V
N
A
Q
S
Q
K
G
F
T
P
L
Site 6
T113
A
Q
S
Q
K
G
F
T
P
L
Y
M
A
A
Q
Site 7
Y116
Q
K
G
F
T
P
L
Y
M
A
A
Q
E
N
H
Site 8
T188
A
R
N
D
D
T
R
T
A
A
V
L
L
Q
N
Site 9
S203
D
P
N
P
D
V
L
S
K
T
G
F
T
P
L
Site 10
T205
N
P
D
V
L
S
K
T
G
F
T
P
L
H
I
Site 11
T208
V
L
S
K
T
G
F
T
P
L
H
I
A
A
H
Site 12
Y216
P
L
H
I
A
A
H
Y
E
N
L
N
V
A
Q
Site 13
S231
L
L
L
N
R
G
A
S
V
N
F
T
P
Q
N
Site 14
T235
R
G
A
S
V
N
F
T
P
Q
N
G
I
T
P
Site 15
T241
F
T
P
Q
N
G
I
T
P
L
H
I
A
S
R
Site 16
T274
T
K
T
K
D
E
L
T
P
L
H
C
A
A
R
Site 17
S288
R
N
G
H
V
R
I
S
E
I
L
L
D
H
G
Site 18
T302
G
A
P
I
Q
A
K
T
K
N
G
L
S
P
I
Site 19
S307
A
K
T
K
N
G
L
S
P
I
H
M
A
A
Q
Site 20
T335
D
A
E
I
D
D
I
T
L
D
H
L
T
P
L
Site 21
S366
D
K
G
A
K
P
N
S
R
A
L
N
G
F
T
Site 22
S429
N
L
L
Q
R
G
A
S
P
N
V
S
N
V
K
Site 23
S433
R
G
A
S
P
N
V
S
N
V
K
V
E
T
P
Site 24
T439
V
S
N
V
K
V
E
T
P
L
H
M
A
A
R
Site 25
Y455
G
H
T
E
V
A
K
Y
L
L
Q
N
K
A
K
Site 26
T472
A
K
A
K
D
D
Q
T
P
L
H
C
A
A
R
Site 27
S528
A
L
L
E
K
E
A
S
Q
A
C
M
T
K
K
Site 28
T538
C
M
T
K
K
G
F
T
P
L
H
V
A
A
K
Site 29
Y546
P
L
H
V
A
A
K
Y
G
K
V
R
V
A
E
Site 30
S594
L
L
L
P
R
G
G
S
P
H
S
P
A
W
N
Site 31
S597
P
R
G
G
S
P
H
S
P
A
W
N
G
Y
T
Site 32
Y603
H
S
P
A
W
N
G
Y
T
P
L
H
I
A
A
Site 33
T604
S
P
A
W
N
G
Y
T
P
L
H
I
A
A
K
Site 34
S620
N
Q
V
E
V
A
R
S
L
L
Q
Y
G
G
S
Site 35
Y624
V
A
R
S
L
L
Q
Y
G
G
S
A
N
A
E
Site 36
S627
S
L
L
Q
Y
G
G
S
A
N
A
E
S
V
Q
Site 37
S632
G
G
S
A
N
A
E
S
V
Q
G
V
T
P
L
Site 38
S667
N
G
N
L
G
N
K
S
G
L
T
P
L
H
L
Site 39
T697
H
G
V
M
V
D
A
T
T
R
M
G
Y
T
P
Site 40
Y702
D
A
T
T
R
M
G
Y
T
P
L
H
V
A
S
Site 41
T703
A
T
T
R
M
G
Y
T
P
L
H
V
A
S
H
Site 42
Y711
P
L
H
V
A
S
H
Y
G
N
I
K
L
V
K
Site 43
Y735
N
A
K
T
K
L
G
Y
S
P
L
H
Q
A
A
Site 44
S736
A
K
T
K
L
G
Y
S
P
L
H
Q
A
A
Q
Site 45
S759
L
L
L
K
N
G
A
S
P
N
E
V
S
S
D
Site 46
S765
A
S
P
N
E
V
S
S
D
G
T
T
P
L
A
Site 47
T768
N
E
V
S
S
D
G
T
T
P
L
A
I
A
K
Site 48
T769
E
V
S
S
D
G
T
T
P
L
A
I
A
K
R
Site 49
S781
A
K
R
L
G
Y
I
S
V
T
D
V
L
K
V
Site 50
S794
K
V
V
T
D
E
T
S
F
V
L
V
S
D
K
Site 51
S805
V
S
D
K
H
R
M
S
F
P
E
T
V
D
E
Site 52
T809
H
R
M
S
F
P
E
T
V
D
E
I
L
D
V
Site 53
S817
V
D
E
I
L
D
V
S
E
D
E
G
E
E
L
Site 54
S826
D
E
G
E
E
L
I
S
F
K
A
E
R
R
D
Site 55
S834
F
K
A
E
R
R
D
S
R
D
V
D
E
E
K
Site 56
S856
K
L
D
Q
V
V
E
S
P
A
I
P
R
I
P
Site 57
Y884
Q
E
Q
A
S
K
E
Y
D
E
D
S
L
I
P
Site 58
S888
S
K
E
Y
D
E
D
S
L
I
P
S
S
P
A
Site 59
S892
D
E
D
S
L
I
P
S
S
P
A
T
E
T
S
Site 60
S893
E
D
S
L
I
P
S
S
P
A
T
E
T
S
D
Site 61
T896
L
I
P
S
S
P
A
T
E
T
S
D
N
I
S
Site 62
S899
S
S
P
A
T
E
T
S
D
N
I
S
P
V
A
Site 63
S903
T
E
T
S
D
N
I
S
P
V
A
S
P
V
H
Site 64
S925
M
V
D
A
R
G
G
S
M
R
G
S
R
H
N
Site 65
S929
R
G
G
S
M
R
G
S
R
H
N
G
L
R
V
Site 66
T950
C
A
A
P
T
R
I
T
C
R
L
V
K
P
Q
Site 67
S960
L
V
K
P
Q
K
L
S
T
P
P
P
L
A
E
Site 68
T961
V
K
P
Q
K
L
S
T
P
P
P
L
A
E
E
Site 69
S1011
R
E
L
V
V
L
R
S
E
N
G
S
V
W
K
Site 70
S1015
V
L
R
S
E
N
G
S
V
W
K
E
H
R
S
Site 71
S1022
S
V
W
K
E
H
R
S
R
Y
G
E
S
Y
L
Site 72
Y1024
W
K
E
H
R
S
R
Y
G
E
S
Y
L
D
Q
Site 73
Y1028
R
S
R
Y
G
E
S
Y
L
D
Q
I
L
N
G
Site 74
S1042
G
M
D
E
E
L
G
S
L
E
E
L
E
K
K
Site 75
Y1073
M
S
R
L
C
Q
D
Y
D
T
I
G
P
E
G
Site 76
T1075
R
L
C
Q
D
Y
D
T
I
G
P
E
G
G
S
Site 77
S1082
T
I
G
P
E
G
G
S
L
K
S
K
L
V
P
Site 78
S1085
P
E
G
G
S
L
K
S
K
L
V
P
L
V
Q
Site 79
T1101
T
F
P
E
N
A
V
T
K
R
V
K
L
A
L
Site 80
T1133
A
T
F
S
P
I
V
T
V
E
P
R
R
R
K
Site 81
S1154
L
R
I
P
L
P
P
S
W
T
D
N
P
R
D
Site 82
T1156
I
P
L
P
P
S
W
T
D
N
P
R
D
S
G
Site 83
S1162
W
T
D
N
P
R
D
S
G
E
G
D
T
T
S
Site 84
T1168
D
S
G
E
G
D
T
T
S
L
R
L
L
C
S
Site 85
S1169
S
G
E
G
D
T
T
S
L
R
L
L
C
S
V
Site 86
T1189
Q
A
Q
W
E
D
I
T
G
T
T
K
L
V
Y
Site 87
Y1196
T
G
T
T
K
L
V
Y
A
N
E
C
A
N
F
Site 88
S1214
V
S
A
R
F
W
L
S
D
C
P
R
T
A
E
Site 89
Y1259
R
E
G
R
L
R
C
Y
C
M
T
D
D
K
V
Site 90
T1262
R
L
R
C
Y
C
M
T
D
D
K
V
D
K
T
Site 91
T1269
T
D
D
K
V
D
K
T
L
E
Q
H
E
N
F
Site 92
S1282
N
F
V
E
V
A
R
S
R
D
I
E
V
L
E
Site 93
S1312
K
K
A
A
Q
Q
R
S
F
H
F
Q
S
F
R
Site 94
S1317
Q
R
S
F
H
F
Q
S
F
R
E
N
R
L
A
Site 95
S1332
M
P
V
K
V
R
D
S
S
R
E
P
G
G
S
Site 96
S1333
P
V
K
V
R
D
S
S
R
E
P
G
G
S
L
Site 97
S1339
S
S
R
E
P
G
G
S
L
S
F
L
R
K
A
Site 98
S1341
R
E
P
G
G
S
L
S
F
L
R
K
A
M
K
Site 99
Y1349
F
L
R
K
A
M
K
Y
E
D
T
Q
H
I
L
Site 100
T1378
G
A
E
D
R
R
R
T
P
T
P
L
A
L
R
Site 101
T1380
E
D
R
R
R
T
P
T
P
L
A
L
R
Y
S
Site 102
Y1386
P
T
P
L
A
L
R
Y
S
I
L
S
E
S
T
Site 103
S1387
T
P
L
A
L
R
Y
S
I
L
S
E
S
T
P
Site 104
S1390
A
L
R
Y
S
I
L
S
E
S
T
P
G
S
L
Site 105
S1392
R
Y
S
I
L
S
E
S
T
P
G
S
L
S
G
Site 106
T1393
Y
S
I
L
S
E
S
T
P
G
S
L
S
G
T
Site 107
S1396
L
S
E
S
T
P
G
S
L
S
G
T
E
Q
A
Site 108
S1398
E
S
T
P
G
S
L
S
G
T
E
Q
A
E
M
Site 109
T1400
T
P
G
S
L
S
G
T
E
Q
A
E
M
K
M
Site 110
S1417
I
S
E
H
L
G
L
S
W
A
E
L
A
R
E
Site 111
S1428
L
A
R
E
L
Q
F
S
V
E
D
I
N
R
I
Site 112
S1442
I
R
V
E
N
P
N
S
L
L
E
Q
S
V
A
Site 113
Y1468
N
A
N
M
E
N
L
Y
T
A
L
Q
S
I
D
Site 114
T1469
A
N
M
E
N
L
Y
T
A
L
Q
S
I
D
R
Site 115
S1486
I
V
N
M
L
E
G
S
G
R
Q
S
R
N
L
Site 116
S1490
L
E
G
S
G
R
Q
S
R
N
L
K
P
D
R
Site 117
T1500
L
K
P
D
R
R
H
T
D
R
D
Y
S
L
S
Site 118
Y1504
R
R
H
T
D
R
D
Y
S
L
S
P
S
Q
M
Site 119
S1505
R
H
T
D
R
D
Y
S
L
S
P
S
Q
M
N
Site 120
S1507
T
D
R
D
Y
S
L
S
P
S
Q
M
N
G
Y
Site 121
S1509
R
D
Y
S
L
S
P
S
Q
M
N
G
Y
S
S
Site 122
S1516
S
Q
M
N
G
Y
S
S
L
Q
D
E
L
L
S
Site 123
S1533
S
L
G
C
A
L
S
S
P
L
R
A
D
Q
Y
Site 124
Y1540
S
P
L
R
A
D
Q
Y
W
N
E
V
A
V
L
Site 125
S1576
W
S
A
G
L
T
P
S
L
V
T
A
E
D
S
Site 126
S1583
S
L
V
T
A
E
D
S
S
L
E
C
S
K
A
Site 127
S1584
L
V
T
A
E
D
S
S
L
E
C
S
K
A
E
Site 128
S1588
E
D
S
S
L
E
C
S
K
A
E
D
S
D
A
Site 129
S1593
E
C
S
K
A
E
D
S
D
A
T
G
H
E
W
Site 130
S1607
W
K
L
E
G
A
L
S
E
E
P
R
G
P
E
Site 131
S1617
P
R
G
P
E
L
G
S
L
E
L
V
E
D
D
Site 132
T1625
L
E
L
V
E
D
D
T
V
D
S
D
A
T
N
Site 133
S1628
V
E
D
D
T
V
D
S
D
A
T
N
G
L
I
Site 134
S1646
E
Q
E
E
G
Q
R
S
E
E
K
L
P
G
S
Site 135
S1653
S
E
E
K
L
P
G
S
K
R
Q
D
D
A
T
Site 136
T1660
S
K
R
Q
D
D
A
T
G
A
G
Q
D
S
E
Site 137
S1666
A
T
G
A
G
Q
D
S
E
N
E
V
S
L
V
Site 138
S1671
Q
D
S
E
N
E
V
S
L
V
S
G
H
Q
R
Site 139
T1684
Q
R
G
Q
A
R
I
T
H
S
P
T
V
S
Q
Site 140
S1686
G
Q
A
R
I
T
H
S
P
T
V
S
Q
V
T
Site 141
T1688
A
R
I
T
H
S
P
T
V
S
Q
V
T
E
R
Site 142
S1690
I
T
H
S
P
T
V
S
Q
V
T
E
R
S
Q
Site 143
S1696
V
S
Q
V
T
E
R
S
Q
D
R
L
Q
D
W
Site 144
S1708
Q
D
W
D
A
D
G
S
I
V
S
Y
L
Q
D
Site 145
Y1712
A
D
G
S
I
V
S
Y
L
Q
D
A
A
Q
G
Site 146
T1726
G
S
W
Q
E
E
V
T
Q
G
P
H
S
F
Q
Site 147
S1731
E
V
T
Q
G
P
H
S
F
Q
G
T
S
T
M
Site 148
T1735
G
P
H
S
F
Q
G
T
S
T
M
T
E
G
L
Site 149
S1747
E
G
L
E
P
G
G
S
Q
E
Y
E
K
V
L
Site 150
Y1750
E
P
G
G
S
Q
E
Y
E
K
V
L
V
S
V
Site 151
S1756
E
Y
E
K
V
L
V
S
V
S
E
H
T
W
T
Site 152
S1758
E
K
V
L
V
S
V
S
E
H
T
W
T
E
Q
Site 153
T1763
S
V
S
E
H
T
W
T
E
Q
P
E
A
E
S
Site 154
S1771
E
Q
P
E
A
E
S
S
Q
A
D
R
D
R
R
Site 155
T1792
Q
V
Q
E
A
K
N
T
F
T
Q
V
V
Q
G
Site 156
T1816
Q
V
T
E
E
Q
F
T
D
E
Q
G
N
I
V
Site 157
S1838
V
V
R
Q
I
D
L
S
S
A
D
A
A
Q
E
Site 158
T1850
A
Q
E
H
E
E
V
T
V
E
G
P
L
E
D
Site 159
S1859
E
G
P
L
E
D
P
S
E
L
E
V
D
I
D
Site 160
Y1867
E
L
E
V
D
I
D
Y
F
M
K
H
S
K
D
Site 161
T1876
M
K
H
S
K
D
H
T
S
T
P
N
P
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation