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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PPP3CB
Full Name:
Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
Alias:
EC 3.1.3.16; Calcineurin A subunit beta isoform; CAM-PRP catalytic subunit; P2BB; PP2B,C-beta; PP2BB; PP2B-beta
Type:
Protein-serine phosphatase
Mass (Da):
59024
Number AA:
524
UniProt ID:
P16298
International Prot ID:
IPI00027809
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005955
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0005516
GO:0005506
PhosphoSite+
KinaseNET
Biological Process:
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T35
K
A
V
P
F
P
P
T
H
R
L
T
S
E
E
Site 2
T39
F
P
P
T
H
R
L
T
S
E
E
V
F
D
L
Site 3
S40
P
P
T
H
R
L
T
S
E
E
V
F
D
L
D
Site 4
T86
A
I
L
R
R
E
K
T
M
I
E
V
E
A
P
Site 5
S116
K
L
F
E
V
G
G
S
P
A
N
T
R
Y
L
Site 6
T120
V
G
G
S
P
A
N
T
R
Y
L
F
L
G
D
Site 7
Y122
G
S
P
A
N
T
R
Y
L
F
L
G
D
Y
V
Site 8
Y128
R
Y
L
F
L
G
D
Y
V
D
R
G
Y
F
S
Site 9
Y168
E
C
R
H
L
T
E
Y
F
T
F
K
Q
E
C
Site 10
Y179
K
Q
E
C
K
I
K
Y
S
E
R
V
Y
E
A
Site 11
Y184
I
K
Y
S
E
R
V
Y
E
A
C
M
E
A
F
Site 12
S242
P
M
C
D
L
L
W
S
D
P
S
E
D
F
G
Site 13
S245
D
L
L
W
S
D
P
S
E
D
F
G
N
E
K
Site 14
S253
E
D
F
G
N
E
K
S
Q
E
H
F
S
H
N
Site 15
S258
E
K
S
Q
E
H
F
S
H
N
T
V
R
G
C
Site 16
Y267
N
T
V
R
G
C
S
Y
F
Y
N
Y
P
A
V
Site 17
Y269
V
R
G
C
S
Y
F
Y
N
Y
P
A
V
C
E
Site 18
Y297
H
E
A
Q
D
A
G
Y
R
M
Y
R
K
S
Q
Site 19
Y300
Q
D
A
G
Y
R
M
Y
R
K
S
Q
T
T
G
Site 20
S303
G
Y
R
M
Y
R
K
S
Q
T
T
G
F
P
S
Site 21
T306
M
Y
R
K
S
Q
T
T
G
F
P
S
L
I
T
Site 22
Y320
T
I
F
S
A
P
N
Y
L
D
V
Y
N
N
K
Site 23
Y324
A
P
N
Y
L
D
V
Y
N
N
K
A
A
V
L
Site 24
Y333
N
K
A
A
V
L
K
Y
E
N
N
V
M
N
I
Site 25
S420
G
K
M
A
R
V
F
S
V
L
R
E
E
S
E
Site 26
S426
F
S
V
L
R
E
E
S
E
S
V
L
T
L
K
Site 27
S428
V
L
R
E
E
S
E
S
V
L
T
L
K
G
L
Site 28
T431
E
E
S
E
S
V
L
T
L
K
G
L
T
P
T
Site 29
S455
G
G
R
Q
T
L
Q
S
A
T
V
E
A
I
E
Site 30
S471
E
K
A
I
R
G
F
S
P
P
H
R
I
C
S
Site 31
S478
S
P
P
H
R
I
C
S
F
E
E
A
K
G
L
Site 32
S506
V
Q
Q
D
G
F
N
S
L
N
T
A
H
A
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation