KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
Nck1
Full Name:
Cytoplasmic protein NCK1
Alias:
MNCK-ALPHA; NCK; NCK adaptor protein 1; SH2/SH3 adaptor protein; SH2/SH3 adaptor protein NCK-alpha
Type:
Adapter/scaffold protein
Mass (Da):
42864
Number AA:
377
UniProt ID:
P16333
International Prot ID:
IPI00028065
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005783
GO:0005783
GO:0012506
Uniprot
OncoNet
Molecular Function:
GO:0008093
GO:0005102
GO:0030159
PhosphoSite+
KinaseNET
Biological Process:
GO:0042110
GO:0042102
GO:0030838
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y13
V
V
V
A
K
F
D
Y
V
A
Q
Q
E
Q
E
Site 2
T48
V
R
N
S
M
N
K
T
G
F
V
P
S
N
Y
Site 3
S53
N
K
T
G
F
V
P
S
N
Y
V
E
R
K
N
Site 4
Y55
T
G
F
V
P
S
N
Y
V
E
R
K
N
S
A
Site 5
S61
N
Y
V
E
R
K
N
S
A
R
K
A
S
I
V
Site 6
S66
K
N
S
A
R
K
A
S
I
V
K
N
L
K
D
Site 7
T74
I
V
K
N
L
K
D
T
L
G
I
G
K
V
K
Site 8
S85
G
K
V
K
R
K
P
S
V
P
D
S
A
S
P
Site 9
S89
R
K
P
S
V
P
D
S
A
S
P
A
D
D
S
Site 10
S91
P
S
V
P
D
S
A
S
P
A
D
D
S
F
V
Site 11
S96
S
A
S
P
A
D
D
S
F
V
D
P
G
E
R
Site 12
Y105
V
D
P
G
E
R
L
Y
D
L
N
M
P
A
Y
Site 13
Y112
Y
D
L
N
M
P
A
Y
V
K
F
N
Y
M
A
Site 14
Y117
P
A
Y
V
K
F
N
Y
M
A
E
R
E
D
E
Site 15
S126
A
E
R
E
D
E
L
S
L
I
K
G
T
K
V
Site 16
Y159
V
G
W
F
P
S
N
Y
V
T
E
E
G
D
S
Site 17
T161
W
F
P
S
N
Y
V
T
E
E
G
D
S
P
L
Site 18
S166
Y
V
T
E
E
G
D
S
P
L
G
D
H
V
G
Site 19
S174
P
L
G
D
H
V
G
S
L
S
E
K
L
A
A
Site 20
Y199
L
H
V
V
Q
A
L
Y
P
F
S
S
S
N
D
Site 21
S202
V
Q
A
L
Y
P
F
S
S
S
N
D
E
E
L
Site 22
S203
Q
A
L
Y
P
F
S
S
S
N
D
E
E
L
N
Site 23
S204
A
L
Y
P
F
S
S
S
N
D
E
E
L
N
F
Site 24
T256
V
M
Q
N
N
P
L
T
S
G
L
E
P
S
P
Site 25
S262
L
T
S
G
L
E
P
S
P
P
Q
C
D
Y
I
Site 26
Y268
P
S
P
P
Q
C
D
Y
I
R
P
S
L
T
G
Site 27
S272
Q
C
D
Y
I
R
P
S
L
T
G
K
F
A
G
Site 28
Y283
K
F
A
G
N
P
W
Y
Y
G
K
V
T
R
H
Site 29
Y284
F
A
G
N
P
W
Y
Y
G
K
V
T
R
H
Q
Site 30
S310
G
D
F
L
I
R
D
S
E
S
S
P
N
D
F
Site 31
S312
F
L
I
R
D
S
E
S
S
P
N
D
F
S
V
Site 32
S313
L
I
R
D
S
E
S
S
P
N
D
F
S
V
S
Site 33
S318
E
S
S
P
N
D
F
S
V
S
L
K
A
Q
G
Site 34
S320
S
P
N
D
F
S
V
S
L
K
A
Q
G
K
N
Site 35
T337
F
K
V
Q
L
K
E
T
V
Y
C
I
G
Q
R
Site 36
Y339
V
Q
L
K
E
T
V
Y
C
I
G
Q
R
K
F
Site 37
S347
C
I
G
Q
R
K
F
S
T
M
E
E
L
V
E
Site 38
S364
K
K
A
P
I
F
T
S
E
Q
G
E
K
L
Y
Site 39
Y371
S
E
Q
G
E
K
L
Y
L
V
K
H
L
S
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation