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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PRLR
Full Name:
Prolactin receptor
Alias:
Lactogen receptor; PRL-R; Prolactin receptor
Type:
Receptor, cytokine
Mass (Da):
69506
Number AA:
622
UniProt ID:
P16471
International Prot ID:
IPI00028640
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0009986
GO:0005576
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0042978
GO:0017046
GO:0004925
PhosphoSite+
KinaseNET
Biological Process:
GO:0042110
GO:0042977
GO:0007171
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S195
Q
T
E
F
K
I
L
S
L
H
P
G
Q
K
Y
Site 2
Y202
S
L
H
P
G
Q
K
Y
L
V
Q
V
R
C
K
Site 3
S289
H
L
L
E
K
G
K
S
E
E
L
L
S
A
L
Site 4
S294
G
K
S
E
E
L
L
S
A
L
G
C
Q
D
F
Site 5
S305
C
Q
D
F
P
P
T
S
D
Y
E
D
L
L
V
Site 6
Y307
D
F
P
P
T
S
D
Y
E
D
L
L
V
E
Y
Site 7
Y314
Y
E
D
L
L
V
E
Y
L
E
V
D
D
S
E
Site 8
S320
E
Y
L
E
V
D
D
S
E
D
Q
H
L
M
S
Site 9
S327
S
E
D
Q
H
L
M
S
V
H
S
K
E
H
P
Site 10
S330
Q
H
L
M
S
V
H
S
K
E
H
P
S
Q
G
Site 11
S335
V
H
S
K
E
H
P
S
Q
G
M
K
P
T
Y
Site 12
Y342
S
Q
G
M
K
P
T
Y
L
D
P
D
T
D
S
Site 13
T347
P
T
Y
L
D
P
D
T
D
S
G
R
G
S
C
Site 14
S349
Y
L
D
P
D
T
D
S
G
R
G
S
C
D
S
Site 15
S353
D
T
D
S
G
R
G
S
C
D
S
P
S
L
L
Site 16
S356
S
G
R
G
S
C
D
S
P
S
L
L
S
E
K
Site 17
S358
R
G
S
C
D
S
P
S
L
L
S
E
K
C
E
Site 18
S361
C
D
S
P
S
L
L
S
E
K
C
E
E
P
Q
Site 19
S372
E
E
P
Q
A
N
P
S
T
F
Y
D
P
E
V
Site 20
T373
E
P
Q
A
N
P
S
T
F
Y
D
P
E
V
I
Site 21
T388
E
K
P
E
N
P
E
T
T
H
T
W
D
P
Q
Site 22
T391
E
N
P
E
T
T
H
T
W
D
P
Q
C
I
S
Site 23
Y405
S
M
E
G
K
I
P
Y
F
H
A
G
G
S
K
Site 24
T415
A
G
G
S
K
C
S
T
W
P
L
P
Q
P
S
Site 25
S422
T
W
P
L
P
Q
P
S
Q
H
N
P
R
S
S
Site 26
S428
P
S
Q
H
N
P
R
S
S
Y
H
N
I
T
D
Site 27
S429
S
Q
H
N
P
R
S
S
Y
H
N
I
T
D
V
Site 28
Y430
Q
H
N
P
R
S
S
Y
H
N
I
T
D
V
C
Site 29
T434
R
S
S
Y
H
N
I
T
D
V
C
E
L
A
V
Site 30
T449
G
P
A
G
A
P
A
T
L
L
N
E
A
G
K
Site 31
S461
A
G
K
D
A
L
K
S
S
Q
T
I
K
S
R
Site 32
S462
G
K
D
A
L
K
S
S
Q
T
I
K
S
R
E
Site 33
T474
S
R
E
E
G
K
A
T
Q
Q
R
E
V
E
S
Site 34
S481
T
Q
Q
R
E
V
E
S
F
H
S
E
T
D
Q
Site 35
S484
R
E
V
E
S
F
H
S
E
T
D
Q
D
T
P
Site 36
T490
H
S
E
T
D
Q
D
T
P
W
L
L
P
Q
E
Site 37
T499
W
L
L
P
Q
E
K
T
P
F
G
S
A
K
P
Site 38
Y509
G
S
A
K
P
L
D
Y
V
E
I
H
K
V
N
Site 39
S522
V
N
K
D
G
A
L
S
L
L
P
K
Q
R
E
Site 40
S531
L
P
K
Q
R
E
N
S
G
K
P
K
K
P
G
Site 41
T539
G
K
P
K
K
P
G
T
P
E
N
N
K
E
Y
Site 42
Y546
T
P
E
N
N
K
E
Y
A
K
V
S
G
V
M
Site 43
S582
S
A
K
E
A
P
P
S
L
E
Q
N
Q
A
E
Site 44
T596
E
K
A
L
A
N
F
T
A
T
S
S
K
C
R
Site 45
S600
A
N
F
T
A
T
S
S
K
C
R
L
Q
L
G
Site 46
Y611
L
Q
L
G
G
L
D
Y
L
D
P
A
C
F
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation