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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PDE6A
Full Name:
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha
Alias:
PDE V-B1
Type:
Mass (Da):
99547
Number AA:
860
UniProt ID:
P16499
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S15
E
V
E
K
F
L
D
S
N
I
G
F
A
K
Q
Site 2
Y24
I
G
F
A
K
Q
Y
Y
N
L
H
Y
R
A
K
Site 3
S34
H
Y
R
A
K
L
I
S
D
L
L
G
A
K
E
Site 4
S47
K
E
A
A
V
D
F
S
N
Y
H
S
P
S
S
Site 5
Y49
A
A
V
D
F
S
N
Y
H
S
P
S
S
M
E
Site 6
S51
V
D
F
S
N
Y
H
S
P
S
S
M
E
E
S
Site 7
S53
F
S
N
Y
H
S
P
S
S
M
E
E
S
E
I
Site 8
S54
S
N
Y
H
S
P
S
S
M
E
E
S
E
I
I
Site 9
S58
S
P
S
S
M
E
E
S
E
I
I
F
D
L
L
Site 10
S95
L
L
Q
A
D
R
M
S
L
F
M
Y
R
T
R
Site 11
Y99
D
R
M
S
L
F
M
Y
R
T
R
N
G
I
A
Site 12
T156
K
I
A
N
V
P
N
T
E
E
D
E
H
F
C
Site 13
T170
C
D
F
V
D
I
L
T
E
Y
K
T
K
N
I
Site 14
T174
D
I
L
T
E
Y
K
T
K
N
I
L
A
S
P
Site 15
S180
K
T
K
N
I
L
A
S
P
I
M
N
G
K
D
Site 16
T235
S
Y
L
H
N
C
E
T
R
R
G
Q
I
L
L
Site 17
S244
R
G
Q
I
L
L
W
S
G
S
K
V
F
E
E
Site 18
T253
S
K
V
F
E
E
L
T
D
I
E
R
Q
F
H
Site 19
Y264
R
Q
F
H
K
A
L
Y
T
V
R
A
F
L
N
Site 20
Y275
A
F
L
N
C
D
R
Y
S
V
G
L
L
D
M
Site 21
T283
S
V
G
L
L
D
M
T
K
Q
K
E
F
F
D
Site 22
Y302
L
M
G
E
V
P
P
Y
S
G
P
R
T
P
D
Site 23
S303
M
G
E
V
P
P
Y
S
G
P
R
T
P
D
G
Site 24
T307
P
P
Y
S
G
P
R
T
P
D
G
R
E
I
N
Site 25
Y316
D
G
R
E
I
N
F
Y
K
V
I
D
Y
I
L
Site 26
Y321
N
F
Y
K
V
I
D
Y
I
L
H
G
K
E
D
Site 27
T402
E
E
I
V
G
V
A
T
F
Y
N
R
K
D
G
Site 28
Y404
I
V
G
V
A
T
F
Y
N
R
K
D
G
K
P
Site 29
T418
P
F
D
E
M
D
E
T
L
M
E
S
L
T
Q
Site 30
T436
W
S
V
L
N
P
D
T
Y
E
S
M
N
K
L
Site 31
Y437
S
V
L
N
P
D
T
Y
E
S
M
N
K
L
E
Site 32
Y456
I
F
Q
D
I
V
K
Y
H
V
K
C
D
N
E
Site 33
Y475
I
L
K
T
R
E
V
Y
G
K
E
P
W
E
C
Site 34
Y501
E
L
P
D
A
D
K
Y
E
I
N
K
F
H
F
Site 35
S509
E
I
N
K
F
H
F
S
D
L
P
L
T
E
L
Site 36
Y527
K
C
G
I
Q
M
Y
Y
E
L
K
V
V
D
K
Site 37
Y547
E
A
L
V
R
F
M
Y
S
L
S
K
G
Y
R
Site 38
S548
A
L
V
R
F
M
Y
S
L
S
K
G
Y
R
K
Site 39
S550
V
R
F
M
Y
S
L
S
K
G
Y
R
K
I
T
Site 40
Y558
K
G
Y
R
K
I
T
Y
H
N
W
R
H
G
F
Site 41
Y583
V
T
G
K
L
K
R
Y
F
T
D
L
E
A
L
Site 42
T585
G
K
L
K
R
Y
F
T
D
L
E
A
L
A
M
Site 43
Y610
H
R
G
T
N
N
L
Y
Q
M
K
S
Q
N
P
Site 44
S614
N
N
L
Y
Q
M
K
S
Q
N
P
L
A
K
L
Site 45
T637
H
H
L
E
F
G
K
T
L
L
R
D
E
S
L
Site 46
S643
K
T
L
L
R
D
E
S
L
N
I
F
Q
N
L
Site 47
S688
F
Q
K
I
V
D
Q
S
K
T
Y
E
S
E
Q
Site 48
T690
K
I
V
D
Q
S
K
T
Y
E
S
E
Q
E
W
Site 49
Y700
S
E
Q
E
W
T
Q
Y
M
M
L
E
Q
T
R
Site 50
T751
E
Q
G
D
L
E
R
T
V
L
Q
Q
N
P
I
Site 51
Y785
D
F
V
C
T
F
V
Y
K
E
F
S
R
F
H
Site 52
T796
S
R
F
H
E
E
I
T
P
M
L
D
G
I
T
Site 53
Y816
W
K
A
L
A
D
E
Y
D
A
K
M
K
V
Q
Site 54
S835
Q
K
Q
Q
S
A
K
S
A
A
A
G
N
Q
P
Site 55
S847
N
Q
P
G
G
N
P
S
P
G
G
A
T
T
S
Site 56
T852
N
P
S
P
G
G
A
T
T
S
K
S
C
C
I
Site 57
S854
S
P
G
G
A
T
T
S
K
S
C
C
I
Q
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation