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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Fer
Full Name:
Tyrosine-protein kinase Fer
Alias:
C-FER; EC 2.7.10.2; FER; Fer (fps/fes related) tyrosine kinase; FERT2; Kinase Fer; P94-FER; Phosphoprotein NCP94; TYK3
Type:
Protein kinase, tyrosine (non-receptor); EC 2.7.10.2; TK group; Fer family
Mass (Da):
94638
Number AA:
822
UniProt ID:
P16591
International Prot ID:
IPI00029263
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004715
PhosphoSite+
KinaseNET
Biological Process:
GO:0007242
GO:0018108
GO:0046777
Phosida
TranscriptoNet
STRING
Kinexus Products
Fer (fps/fes related) protein-tyrosine kinase Y402 phosphosite-specific antibody AB-PK630#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK630#Fer (fps/fes related) protein-tyrosine kinase (G711-S717, human) pY714 phosphopeptide - Powder PE-04AMF99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AMF99#Fer (fps/fes related) protein-tyrosine kinase (V399-D405, human) pY402 phosphopeptide - Powder PE-04AMG99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AMG99
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T27
W
E
L
R
L
L
E
T
V
K
K
F
M
A
L
Site 2
S38
F
M
A
L
R
I
K
S
D
K
E
Y
A
S
T
Site 3
Y42
R
I
K
S
D
K
E
Y
A
S
T
L
Q
N
L
Site 4
T45
S
D
K
E
Y
A
S
T
L
Q
N
L
C
N
Q
Site 5
Y63
E
S
T
V
Q
M
N
Y
V
S
N
V
S
K
S
Site 6
S70
Y
V
S
N
V
S
K
S
W
L
L
M
I
Q
Q
Site 7
S94
T
H
A
E
D
L
N
S
G
P
L
H
R
L
T
Site 8
T101
S
G
P
L
H
R
L
T
M
M
I
K
D
K
Q
Site 9
S113
D
K
Q
Q
V
K
K
S
Y
I
G
V
H
Q
Q
Site 10
Y114
K
Q
Q
V
K
K
S
Y
I
G
V
H
Q
Q
I
Site 11
T131
E
M
I
K
V
T
K
T
E
L
E
K
L
K
C
Site 12
S139
E
L
E
K
L
K
C
S
Y
R
Q
L
I
K
E
Site 13
Y199
A
Q
L
H
Q
N
Q
Y
Y
D
I
T
L
P
L
Site 14
Y200
Q
L
H
Q
N
Q
Y
Y
D
I
T
L
P
L
L
Site 15
T203
Q
N
Q
Y
Y
D
I
T
L
P
L
L
L
D
S
Site 16
S210
T
L
P
L
L
L
D
S
L
Q
K
M
Q
E
E
Site 17
Y229
L
K
G
I
F
D
E
Y
S
Q
I
T
S
L
V
Site 18
S230
K
G
I
F
D
E
Y
S
Q
I
T
S
L
V
T
Site 19
S234
D
E
Y
S
Q
I
T
S
L
V
T
E
E
I
V
Site 20
S250
V
H
K
E
I
Q
M
S
V
E
Q
I
D
P
S
Site 21
S257
S
V
E
Q
I
D
P
S
T
E
Y
N
N
F
I
Site 22
T258
V
E
Q
I
D
P
S
T
E
Y
N
N
F
I
D
Site 23
Y260
Q
I
D
P
S
T
E
Y
N
N
F
I
D
V
H
Site 24
T270
F
I
D
V
H
R
T
T
A
A
K
E
Q
E
I
Site 25
S282
Q
E
I
E
F
D
T
S
L
L
E
E
N
E
N
Site 26
T319
L
A
E
E
L
M
Q
T
Q
Q
M
L
L
N
K
Site 27
S341
E
K
R
I
E
E
S
S
E
T
C
E
K
K
S
Site 28
T343
R
I
E
E
S
S
E
T
C
E
K
K
S
D
I
Site 29
S348
S
E
T
C
E
K
K
S
D
I
V
L
L
L
S
Site 30
S366
A
L
E
E
L
K
Q
S
V
Q
Q
L
R
C
T
Site 31
T373
S
V
Q
Q
L
R
C
T
E
A
K
F
S
A
Q
Site 32
S378
R
C
T
E
A
K
F
S
A
Q
K
E
L
L
E
Site 33
Y402
E
P
P
P
V
V
N
Y
E
E
D
A
R
S
V
Fer (fps/fes related) protein-tyrosine kinase Y402 phosphosite-specific antibody AB-PK630#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK630#Fer (fps/fes related) protein-tyrosine kinase (V399-D405, human) pY402 phosphopeptide - Powder PE-04AMG99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AMG99
Site 34
S408
N
Y
E
E
D
A
R
S
V
T
S
M
E
R
K
Site 35
T410
E
E
D
A
R
S
V
T
S
M
E
R
K
E
R
Site 36
S411
E
D
A
R
S
V
T
S
M
E
R
K
E
R
L
Site 37
S419
M
E
R
K
E
R
L
S
K
F
E
S
I
R
H
Site 38
S423
E
R
L
S
K
F
E
S
I
R
H
S
I
A
G
Site 39
S427
K
F
E
S
I
R
H
S
I
A
G
I
I
R
S
Site 40
S434
S
I
A
G
I
I
R
S
P
K
S
A
L
G
S
Site 41
S441
S
P
K
S
A
L
G
S
S
A
L
S
D
M
I
Site 42
S442
P
K
S
A
L
G
S
S
A
L
S
D
M
I
S
Site 43
S451
L
S
D
M
I
S
I
S
E
K
P
L
A
E
Q
Site 44
Y461
P
L
A
E
Q
D
W
Y
H
G
A
I
P
R
I
Site 45
S485
G
D
F
L
V
R
E
S
H
G
K
P
G
E
Y
Site 46
Y492
S
H
G
K
P
G
E
Y
V
L
S
V
Y
S
D
Site 47
S495
K
P
G
E
Y
V
L
S
V
Y
S
D
G
Q
R
Site 48
Y497
G
E
Y
V
L
S
V
Y
S
D
G
Q
R
R
H
Site 49
S498
E
Y
V
L
S
V
Y
S
D
G
Q
R
R
H
F
Site 50
Y509
R
R
H
F
I
I
Q
Y
V
D
N
M
Y
R
F
Site 51
Y514
I
Q
Y
V
D
N
M
Y
R
F
E
G
T
G
F
Site 52
S522
R
F
E
G
T
G
F
S
N
I
P
Q
L
I
D
Site 53
Y532
P
Q
L
I
D
H
H
Y
T
T
K
Q
V
I
T
Site 54
Y578
K
G
N
F
G
E
V
Y
K
G
T
L
K
D
K
Site 55
T581
F
G
E
V
Y
K
G
T
L
K
D
K
T
S
V
Site 56
T586
K
G
T
L
K
D
K
T
S
V
A
V
K
T
C
Site 57
S587
G
T
L
K
D
K
T
S
V
A
V
K
T
C
K
Site 58
Y615
E
A
K
I
L
K
Q
Y
D
H
P
N
I
V
K
Site 59
T647
V
S
G
G
D
F
L
T
F
L
R
R
K
K
D
Site 60
Y714
R
Q
E
D
G
G
V
Y
S
S
S
G
L
K
Q
Fer (fps/fes related) protein-tyrosine kinase (G711-S717, human) pY714 phosphopeptide - Powder PE-04AMF99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AMF99
Site 61
S715
Q
E
D
G
G
V
Y
S
S
S
G
L
K
Q
I
Site 62
S716
E
D
G
G
V
Y
S
S
S
G
L
K
Q
I
P
Site 63
S717
D
G
G
V
Y
S
S
S
G
L
K
Q
I
P
I
Site 64
Y734
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
Site 65
Y737
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
Site 66
S738
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
Site 67
S739
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
Site 68
S741
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
Site 69
S745
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
Site 70
Y761
F
S
L
G
V
C
P
Y
P
G
M
T
N
Q
Q
Site 71
Y777
R
E
Q
V
E
R
G
Y
R
M
S
A
P
Q
H
Site 72
S780
V
E
R
G
Y
R
M
S
A
P
Q
H
C
P
E
Site 73
T815
S
E
L
Q
K
E
L
T
I
I
K
R
K
L
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation