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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CPE
Full Name:
Carboxypeptidase E
Alias:
Carboxypeptidase H;Enkephalin convertase;Prohormone-processing carboxypeptidase
Type:
Mass (Da):
53151
Number AA:
476
UniProt ID:
P16870
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S50
L
Q
Q
E
D
G
I
S
F
E
Y
H
R
Y
P
Site 2
Y53
E
D
G
I
S
F
E
Y
H
R
Y
P
E
L
R
Site 3
Y56
I
S
F
E
Y
H
R
Y
P
E
L
R
E
A
L
Site 4
T78
T
A
I
S
R
I
Y
T
V
G
R
S
F
E
G
Site 5
S82
R
I
Y
T
V
G
R
S
F
E
G
R
E
L
L
Site 6
S94
E
L
L
V
I
E
L
S
D
N
P
G
V
H
E
Site 7
Y109
P
G
E
P
E
F
K
Y
I
G
N
M
H
G
N
Site 8
S156
T
R
I
H
I
M
P
S
L
N
P
D
G
F
E
Site 9
S167
D
G
F
E
K
A
A
S
Q
P
G
E
L
K
D
Site 10
Y199
P
D
L
D
R
I
V
Y
V
N
E
K
E
G
G
Site 11
Y256
G
G
D
L
V
A
N
Y
P
Y
D
E
T
R
S
Site 12
Y258
D
L
V
A
N
Y
P
Y
D
E
T
R
S
G
S
Site 13
T261
A
N
Y
P
Y
D
E
T
R
S
G
S
A
H
E
Site 14
S265
Y
D
E
T
R
S
G
S
A
H
E
Y
S
S
S
Site 15
Y269
R
S
G
S
A
H
E
Y
S
S
S
P
D
D
A
Site 16
S270
S
G
S
A
H
E
Y
S
S
S
P
D
D
A
I
Site 17
S272
S
A
H
E
Y
S
S
S
P
D
D
A
I
F
Q
Site 18
S280
P
D
D
A
I
F
Q
S
L
A
R
A
Y
S
S
Site 19
Y285
F
Q
S
L
A
R
A
Y
S
S
F
N
P
A
M
Site 20
S286
Q
S
L
A
R
A
Y
S
S
F
N
P
A
M
S
Site 21
S287
S
L
A
R
A
Y
S
S
F
N
P
A
M
S
D
Site 22
S293
S
S
F
N
P
A
M
S
D
P
N
R
P
P
C
Site 23
S307
C
R
K
N
D
D
D
S
S
F
V
D
G
T
T
Site 24
S308
R
K
N
D
D
D
S
S
F
V
D
G
T
T
N
Site 25
T313
D
S
S
F
V
D
G
T
T
N
G
G
A
W
Y
Site 26
T314
S
S
F
V
D
G
T
T
N
G
G
A
W
Y
S
Site 27
Y320
T
T
N
G
G
A
W
Y
S
V
P
G
G
M
Q
Site 28
Y331
G
G
M
Q
D
F
N
Y
L
S
S
N
C
F
E
Site 29
T340
S
S
N
C
F
E
I
T
V
E
L
S
C
E
K
Site 30
S344
F
E
I
T
V
E
L
S
C
E
K
F
P
P
E
Site 31
T356
P
P
E
E
T
L
K
T
Y
W
E
D
N
K
N
Site 32
Y357
P
E
E
T
L
K
T
Y
W
E
D
N
K
N
S
Site 33
Y368
N
K
N
S
L
I
S
Y
L
E
Q
I
H
R
G
Site 34
S394
P
I
A
N
A
T
I
S
V
E
G
I
D
H
D
Site 35
T403
E
G
I
D
H
D
V
T
S
A
K
D
G
D
Y
Site 36
Y410
T
S
A
K
D
G
D
Y
W
R
L
L
I
P
G
Site 37
T422
I
P
G
N
Y
K
L
T
A
S
A
P
G
Y
L
Site 38
T432
A
P
G
Y
L
A
I
T
K
K
V
A
V
P
Y
Site 39
S440
K
K
V
A
V
P
Y
S
P
A
A
G
V
D
F
Site 40
S451
G
V
D
F
E
L
E
S
F
S
E
R
K
E
E
Site 41
S453
D
F
E
L
E
S
F
S
E
R
K
E
E
E
K
Site 42
T473
W
W
K
M
M
S
E
T
L
N
F
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation