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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GOT1
Full Name:
Aspartate aminotransferase, cytoplasmic
Alias:
AATC; Aspartate aminotransferase 1; Glutamate oxaloacetate transaminase-1; Glutamic-oxaloacetic transaminase 1, soluble; Transaminase A
Type:
Amino Acid Metabolism - tyrosine; Amino Acid Metabolism - phenylalanine, tyrosine and tryptophan biosynthesis; Amino Acid Metabolism - phenylalanine; Transferase; Amino Acid Metabolism - alanine, aspartate and glutamate; EC 2.6.1.1; Amino Acid Metabolism - arginine and proline; Amino Acid Metabolism - cysteine and methionine
Mass (Da):
46116
Number AA:
412
UniProt ID:
P17174
International Prot ID:
IPI00219029
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0004069
GO:0030170
PhosphoSite+
KinaseNET
Biological Process:
GO:0006533
GO:0032869
GO:0051384
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y41
V
N
L
G
V
G
A
Y
R
T
D
D
C
H
P
Site 2
S66
Q
K
I
A
N
D
N
S
L
N
H
E
Y
L
P
Site 3
Y71
D
N
S
L
N
H
E
Y
L
P
I
L
G
L
A
Site 4
S93
R
L
A
L
G
D
D
S
P
A
L
K
E
K
R
Site 5
Y124
A
D
F
L
A
R
W
Y
N
G
T
N
N
K
N
Site 6
T127
L
A
R
W
Y
N
G
T
N
N
K
N
T
P
V
Site 7
T132
N
G
T
N
N
K
N
T
P
V
Y
V
S
S
P
Site 8
Y135
N
N
K
N
T
P
V
Y
V
S
S
P
T
W
E
Site 9
S138
N
T
P
V
Y
V
S
S
P
T
W
E
N
H
N
Site 10
S149
E
N
H
N
A
V
F
S
A
A
G
F
K
D
I
Site 11
Y159
G
F
K
D
I
R
S
Y
R
Y
W
D
A
E
K
Site 12
T202
N
P
T
G
I
D
P
T
P
E
Q
W
K
Q
I
Site 13
S224
F
L
F
P
F
F
D
S
A
Y
Q
G
F
A
S
Site 14
Y226
F
P
F
F
D
S
A
Y
Q
G
F
A
S
G
N
Site 15
Y243
R
D
A
W
A
I
R
Y
F
V
S
E
G
F
E
Site 16
Y264
F
S
K
N
F
G
L
Y
N
E
R
V
G
N
L
Site 17
T272
N
E
R
V
G
N
L
T
V
V
G
K
E
P
E
Site 18
T295
M
E
K
I
V
R
I
T
W
S
N
P
P
A
Q
Site 19
S297
K
I
V
R
I
T
W
S
N
P
P
A
Q
G
A
Site 20
S312
R
I
V
A
S
T
L
S
N
P
E
L
F
E
E
Site 21
T321
P
E
L
F
E
E
W
T
G
N
V
K
T
M
A
Site 22
T333
T
M
A
D
R
I
L
T
M
R
S
E
L
R
A
Site 23
T347
A
R
L
E
A
L
K
T
P
G
T
W
N
H
I
Site 24
T350
E
A
L
K
T
P
G
T
W
N
H
I
T
D
Q
Site 25
S362
T
D
Q
I
G
M
F
S
F
T
G
L
N
P
K
Site 26
Y373
L
N
P
K
Q
V
E
Y
L
V
N
E
K
H
I
Site 27
Y381
L
V
N
E
K
H
I
Y
L
L
P
S
G
R
I
Site 28
S385
K
H
I
Y
L
L
P
S
G
R
I
N
V
S
G
Site 29
Y400
L
T
T
K
N
L
D
Y
V
A
T
S
I
H
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation