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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SMPD1
Full Name:
Sphingomyelin phosphodiesterase
Alias:
Acid sphingomyelinase; ASM; aSMase; EC 3.1.4.12
Type:
Enzyme, phosphodiesterase
Mass (Da):
69851
Number AA:
629
UniProt ID:
P17405
International Prot ID:
IPI00296461
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005764
Uniprot
OncoNet
Molecular Function:
GO:0016798
GO:0004767
PhosphoSite+
KinaseNET
Biological Process:
GO:0007399
GO:0007165
GO:0006685
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
P
R
Y
G
A
S
L
R
Q
S
C
P
R
Site 2
S11
Y
G
A
S
L
R
Q
S
C
P
R
S
G
R
E
Site 3
S15
L
R
Q
S
C
P
R
S
G
R
E
Q
G
Q
D
Site 4
T24
R
E
Q
G
Q
D
G
T
A
G
A
P
G
L
L
Site 5
S63
P
A
E
A
H
P
L
S
P
Q
G
H
P
A
R
Site 6
S149
M
V
E
V
W
R
R
S
V
L
S
P
S
E
A
Site 7
S152
V
W
R
R
S
V
L
S
P
S
E
A
C
G
L
Site 8
T180
S
W
N
I
S
L
P
T
V
P
K
P
P
P
K
Site 9
S190
K
P
P
P
K
P
P
S
P
P
A
P
G
A
P
Site 10
Y213
D
L
H
W
D
H
D
Y
L
E
G
T
D
P
D
Site 11
S231
P
L
C
C
R
R
G
S
G
L
P
P
A
S
R
Site 12
S237
G
S
G
L
P
P
A
S
R
P
G
A
G
Y
W
Site 13
Y243
A
S
R
P
G
A
G
Y
W
G
E
Y
S
K
C
Site 14
T256
K
C
D
L
P
L
R
T
L
E
S
L
L
S
G
Site 15
S321
P
A
V
G
N
H
E
S
T
P
V
N
S
F
P
Site 16
T322
A
V
G
N
H
E
S
T
P
V
N
S
F
P
P
Site 17
S326
H
E
S
T
P
V
N
S
F
P
P
P
F
I
E
Site 18
S337
P
F
I
E
G
N
H
S
S
R
W
L
Y
E
A
Site 19
Y342
N
H
S
S
R
W
L
Y
E
A
M
A
K
A
W
Site 20
S396
N
F
W
L
L
I
N
S
T
D
P
A
G
Q
L
Site 21
Y439
L
K
S
W
S
W
N
Y
Y
R
I
V
A
R
Y
Site 22
Y440
K
S
W
S
W
N
Y
Y
R
I
V
A
R
Y
E
Site 23
Y446
Y
Y
R
I
V
A
R
Y
E
N
T
L
A
A
Q
Site 24
Y467
V
D
E
F
E
V
F
Y
D
E
E
T
L
S
R
Site 25
T471
E
V
F
Y
D
E
E
T
L
S
R
P
L
A
V
Site 26
Y495
Y
I
G
L
N
P
G
Y
R
V
Y
Q
I
D
G
Site 27
Y498
L
N
P
G
Y
R
V
Y
Q
I
D
G
N
Y
S
Site 28
Y504
V
Y
Q
I
D
G
N
Y
S
G
S
S
H
V
V
Site 29
S507
I
D
G
N
Y
S
G
S
S
H
V
V
L
D
H
Site 30
S508
D
G
N
Y
S
R
S
S
H
V
V
L
D
H
E
Site 31
Y537
I
P
H
W
Q
L
L
Y
R
A
R
E
T
Y
G
Site 32
T542
L
L
Y
R
A
R
E
T
Y
G
L
P
N
T
L
Site 33
Y543
L
Y
R
A
R
E
T
Y
G
L
P
N
T
L
P
Site 34
T548
E
T
Y
G
L
P
N
T
L
P
T
A
W
H
N
Site 35
T586
P
P
S
E
P
C
G
T
P
C
R
L
A
T
L
Site 36
S603
Q
L
S
A
R
A
D
S
P
A
L
C
R
H
L
Site 37
S615
R
H
L
M
P
D
G
S
L
P
E
A
Q
S
L
Site 38
S621
G
S
L
P
E
A
Q
S
L
W
P
R
P
L
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation