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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
AKR1C4
Full Name:
Aldo-keto reductase family 1 member C4
Alias:
3-alpha hydroxysteroid dehydrogenase, type I; 3-alpha-HSD; 3-alpha-HSD1; 3-alpha-hydroxysteroid dehydrogenase type I; AK1C4; Aldo-keto reductase family 1, member C4; C11; CDR; CHDR; Chlordecone reductase; DD4; Dihydrodiol dehydrogenase 4; EC 1.1.1.-; EC 1.1.1.225; EC 1.1.1.50; HAKRA; MGC22581
Type:
Lipid Metabolism - C21-steroid hormone; EC 1.1.1.50; Lipid Metabolism - androgen and estrogen; Oxidoreductase; Lipid Metabolism - primary bile acid biosynthesis; EC 1.1.1.225; EC 1.1.1.-; Xenobiotic Metabolism - metabolism by cytochrome P450
Mass (Da):
37095
Number AA:
323
UniProt ID:
P17516
International Prot ID:
IPI00289524
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0047042
GO:0004033
GO:0015125
PhosphoSite+
KinaseNET
Biological Process:
GO:0008209
GO:0015721
GO:0055114
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T23
M
P
V
L
G
F
G
T
Y
A
P
P
E
V
P
Site 2
Y24
P
V
L
G
F
G
T
Y
A
P
P
E
V
P
R
Site 3
Y53
F
R
H
I
D
S
A
Y
L
Y
N
N
E
E
Q
Site 4
Y55
H
I
D
S
A
Y
L
Y
N
N
E
E
Q
V
G
Site 5
S73
R
S
K
I
A
D
G
S
V
K
R
E
D
I
F
Site 6
Y81
V
K
R
E
D
I
F
Y
T
S
K
L
W
C
T
Site 7
T82
K
R
E
D
I
F
Y
T
S
K
L
W
C
T
F
Site 8
T127
M
A
L
K
P
G
E
T
P
L
P
K
D
E
N
Site 9
S162
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
Site 10
Y184
L
N
K
P
G
L
K
Y
K
P
V
C
N
Q
V
Site 11
Y196
N
Q
V
E
C
H
P
Y
L
N
Q
S
K
L
L
Site 12
S200
C
H
P
Y
L
N
Q
S
K
L
L
D
F
C
K
Site 13
S208
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Site 14
T221
V
A
H
S
A
L
G
T
Q
R
H
K
L
W
V
Site 15
S232
K
L
W
V
D
P
N
S
P
V
L
L
E
D
P
Site 16
T251
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Site 17
S271
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Site 18
Y272
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
E
Site 19
T289
Q
V
F
E
F
Q
L
T
S
E
D
M
K
V
L
Site 20
Y303
L
D
G
L
N
R
N
Y
R
Y
V
V
M
D
F
Site 21
Y305
G
L
N
R
N
Y
R
Y
V
V
M
D
F
L
M
Site 22
Y317
F
L
M
D
H
P
D
Y
P
F
S
D
E
Y
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation