PhosphoNET

           
Protein Info 
   
Short Name:  TYRP1
Full Name:  5,6-dihydroxyindole-2-carboxylic acid oxidase
Alias:  5,6-dihydroxyindole-2-carboxylic acid oxidase; Associated with iris pigmentation; B-PROTEIN; CAS2; Catalase B; CATB; DHICA oxidase; Glycoprotein 75; GP75; Melanoma antigen gp75; TRP; TRP1; TRP-1; Tyrosinase-related 1; Tyrosinase-related protein 1; TYRP; TYRRP
Type:  Amino Acid Metabolism - tyrosine; Oxidoreductase; EC 1.14.18.-
Mass (Da):  60706
Number AA:  537
UniProt ID:  P17643
International Prot ID:  IPI00015913
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0016021  GO:0033162   Uniprot OncoNet
Molecular Function:  GO:0005507  GO:0016716  GO:0046982 PhosphoSite+ KinaseNET
Biological Process:  GO:0042438  GO:0055114   Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1T32QFPRQCATVEALRSG
Site 2S49CPDLSPVSGPGTDRC
Site 3T53SPVSGPGTDRCGSSS
Site 4S58PGTDRCGSSSGRGRC
Site 5S59GTDRCGSSSGRGRCE
Site 6S60TDRCGSSSGRGRCEA
Site 7T69RGRCEAVTADSRPHS
Site 8S72CEAVTADSRPHSPQY
Site 9S76TADSRPHSPQYPHDG
Site 10Y79SRPHSPQYPHDGRDD
Site 11S137RRNLLDLSKEEKNHF
Site 12S166FVIATRRSEEILGPD
Site 13T176ILGPDGNTPQFENIS
Site 14Y194YFVWTHYYSVKKTFL
Site 15T199HYYSVKKTFLGVGQE
Site 16S214SFGEVDFSHEGPAFL
Site 17Y226AFLTWHRYHLLRLEK
Site 18S243QEMLQEPSFSLPYWN
Site 19Y248EPSFSLPYWNFATGK
Site 20S268CTDDLMGSRSNFDST
Site 21S270DDLMGSRSNFDSTLI
Site 22S274GSRSNFDSTLISPNS
Site 23T275SRSNFDSTLISPNSV
Site 24S278NFDSTLISPNSVFSQ
Site 25S281STLISPNSVFSQWRV
Site 26S292QWRVVCDSLEDYDTL
Site 27T298DSLEDYDTLGTLCNS
Site 28T301EDYDTLGTLCNSTED
Site 29S305TLGTLCNSTEDGPIR
Site 30T344LEVGLFDTPPFYSNS
Site 31Y348LFDTPPFYSNSTNSF
Site 32S349FDTPPFYSNSTNSFR
Site 33S351TPPFYSNSTNSFRNT
Site 34S354FYSNSTNSFRNTVEG
Site 35T358STNSFRNTVEGYSDP
Site 36Y362FRNTVEGYSDPTGKY
Site 37Y369YSDPTGKYDPAVRSL
Site 38S375KYDPAVRSLHNLAHL
Site 39S394TGGQTHLSPNDPIFV
Site 40Y418FDEWLRRYNADISTF
Site 41S423RRYNADISTFPLENA
Site 42T424RYNADISTFPLENAP
Site 43T455TNTEMFVTAPDNLGY
Site 44Y464PDNLGYTYEIQWPSR
Site 45S470TYEIQWPSREFSVPE
Site 46S474QWPSREFSVPEIIAI
Site 47S506YLIRARRSMDEANQP
Site 48Y519QPLLTDQYQCYAEEY
Site 49Y522LTDQYQCYAEEYEKL
Site 50S535KLQNPNQSVV_____
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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