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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Kv1.6
Full Name:
Potassium voltage-gated channel subfamily A member 6
Alias:
HBK2; KCNA6; Potassium voltage-gated channel, shaker-related subfamily, member 6; Voltage-gated potassium channel subunit Kv1.6
Type:
Mass (Da):
58710
Number AA:
529
UniProt ID:
P17658
International Prot ID:
IPI00015931
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0008076
Uniprot
OncoNet
Molecular Function:
GO:0030955
GO:0005515
GO:0005249
PhosphoSite+
KinaseNET
Biological Process:
GO:0006813
GO:0055085
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
R
S
E
K
S
L
T
L
A
A
P
G
Site 2
T8
M
R
S
E
K
S
L
T
L
A
A
P
G
E
V
Site 3
S48
E
R
L
V
I
N
I
S
G
L
R
F
E
T
Q
Site 4
T58
R
F
E
T
Q
L
R
T
L
S
L
F
P
D
T
Site 5
T65
T
L
S
L
F
P
D
T
L
L
G
D
P
G
R
Site 6
Y84
F
D
P
L
R
N
E
Y
F
F
D
R
N
R
P
Site 7
Y98
P
S
F
D
A
I
L
Y
Y
Y
Q
S
G
G
R
Site 8
Y99
S
F
D
A
I
L
Y
Y
Y
Q
S
G
G
R
L
Site 9
Y100
F
D
A
I
L
Y
Y
Y
Q
S
G
G
R
L
R
Site 10
S102
A
I
L
Y
Y
Y
Q
S
G
G
R
L
R
R
P
Site 11
Y124
F
L
E
E
I
R
F
Y
Q
L
G
D
E
A
L
Site 12
S153
E
D
E
K
P
L
P
S
Q
P
F
Q
R
Q
V
Site 13
Y166
Q
V
W
L
L
F
E
Y
P
E
S
S
G
P
A
Site 14
S169
L
L
F
E
Y
P
E
S
S
G
P
A
R
G
I
Site 15
S212
G
G
N
N
G
G
V
S
R
V
S
P
V
S
R
Site 16
S215
N
G
G
V
S
R
V
S
P
V
S
R
G
S
Q
Site 17
S218
V
S
R
V
S
P
V
S
R
G
S
Q
E
E
E
Site 18
S221
V
S
P
V
S
R
G
S
Q
E
E
E
E
D
E
Site 19
S231
E
E
E
D
E
D
D
S
Y
T
F
H
H
G
I
Site 20
Y232
E
E
D
E
D
D
S
Y
T
F
H
H
G
I
T
Site 21
T233
E
D
E
D
D
S
Y
T
F
H
H
G
I
T
P
Site 22
T239
Y
T
F
H
H
G
I
T
P
G
E
M
G
T
G
Site 23
T245
I
T
P
G
E
M
G
T
G
G
S
S
S
L
S
Site 24
S248
G
E
M
G
T
G
G
S
S
S
L
S
T
L
G
Site 25
S249
E
M
G
T
G
G
S
S
S
L
S
T
L
G
G
Site 26
S250
M
G
T
G
G
S
S
S
L
S
T
L
G
G
S
Site 27
S287
V
R
F
S
A
C
P
S
K
P
A
F
F
R
N
Site 28
S325
Q
Q
E
Q
Q
P
A
S
G
G
G
G
Q
N
G
Site 29
S356
V
F
R
I
F
K
L
S
R
H
S
K
G
L
Q
Site 30
S359
I
F
K
L
S
R
H
S
K
G
L
Q
I
L
G
Site 31
T368
G
L
Q
I
L
G
K
T
L
Q
A
S
M
R
E
Site 32
S404
A
E
A
D
D
D
D
S
L
F
P
S
I
P
D
Site 33
Y429
T
V
G
Y
G
D
M
Y
P
M
T
V
G
G
K
Site 34
Y463
V
I
V
S
N
F
N
Y
F
Y
H
R
E
T
E
Site 35
Y465
V
S
N
F
N
Y
F
Y
H
R
E
T
E
Q
E
Site 36
Y477
E
Q
E
E
Q
G
Q
Y
T
H
V
T
C
G
Q
Site 37
T492
P
A
P
D
L
R
A
T
D
N
G
L
G
K
P
Site 38
S511
A
N
R
E
R
R
P
S
Y
L
P
T
P
H
R
Site 39
Y512
N
R
E
R
R
P
S
Y
L
P
T
P
H
R
A
Site 40
T515
R
R
P
S
Y
L
P
T
P
H
R
A
Y
A
E
Site 41
Y520
L
P
T
P
H
R
A
Y
A
E
K
R
M
L
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation