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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Desmin
Full Name:
Desmin
Alias:
CMD1I; CSM1; CSM2; DES; DESM; Intermediate filament protein
Type:
Cytoskeletal protein
Mass (Da):
53536
Number AA:
470
UniProt ID:
P17661
International Prot ID:
IPI00465084
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030018
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0005200
PhosphoSite+
KinaseNET
Biological Process:
GO:0007010
GO:0006936
GO:0008016
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y5
_
_
_
M
S
Q
A
Y
S
S
S
Q
R
V
S
Site 2
S6
_
_
M
S
Q
A
Y
S
S
S
Q
R
V
S
S
Site 3
S7
_
M
S
Q
A
Y
S
S
S
Q
R
V
S
S
Y
Site 4
S8
M
S
Q
A
Y
S
S
S
Q
R
V
S
S
Y
R
Site 5
S12
Y
S
S
S
Q
R
V
S
S
Y
R
R
T
F
G
Site 6
S13
S
S
S
Q
R
V
S
S
Y
R
R
T
F
G
G
Site 7
Y14
S
S
Q
R
V
S
S
Y
R
R
T
F
G
G
A
Site 8
T17
R
V
S
S
Y
R
R
T
F
G
G
A
P
G
F
Site 9
S28
A
P
G
F
P
L
G
S
P
L
S
S
P
V
F
Site 10
S31
F
P
L
G
S
P
L
S
S
P
V
F
P
R
A
Site 11
S32
P
L
G
S
P
L
S
S
P
V
F
P
R
A
G
Site 12
S42
F
P
R
A
G
F
G
S
K
G
S
S
S
S
V
Site 13
S45
A
G
F
G
S
K
G
S
S
S
S
V
T
S
R
Site 14
S46
G
F
G
S
K
G
S
S
S
S
V
T
S
R
V
Site 15
S47
F
G
S
K
G
S
S
S
S
V
T
S
R
V
Y
Site 16
S48
G
S
K
G
S
S
S
S
V
T
S
R
V
Y
Q
Site 17
T50
K
G
S
S
S
S
V
T
S
R
V
Y
Q
V
S
Site 18
S51
G
S
S
S
S
V
T
S
R
V
Y
Q
V
S
R
Site 19
Y54
S
S
V
T
S
R
V
Y
Q
V
S
R
T
S
G
Site 20
S57
T
S
R
V
Y
Q
V
S
R
T
S
G
G
A
G
Site 21
T59
R
V
Y
Q
V
S
R
T
S
G
G
A
G
G
L
Site 22
S60
V
Y
Q
V
S
R
T
S
G
G
A
G
G
L
G
Site 23
S68
G
G
A
G
G
L
G
S
L
R
A
S
R
L
G
Site 24
S72
G
L
G
S
L
R
A
S
R
L
G
T
T
R
T
Site 25
T76
L
R
A
S
R
L
G
T
T
R
T
P
S
S
Y
Site 26
T77
R
A
S
R
L
G
T
T
R
T
P
S
S
Y
G
Site 27
T79
S
R
L
G
T
T
R
T
P
S
S
Y
G
A
G
Site 28
S81
L
G
T
T
R
T
P
S
S
Y
G
A
G
E
L
Site 29
S82
G
T
T
R
T
P
S
S
Y
G
A
G
E
L
L
Site 30
Y83
T
T
R
T
P
S
S
Y
G
A
G
E
L
L
D
Site 31
Y122
L
N
D
R
F
A
N
Y
I
E
K
V
R
F
L
Site 32
T149
R
L
K
G
R
E
P
T
R
V
A
E
L
Y
E
Site 33
Y155
P
T
R
V
A
E
L
Y
E
E
E
L
R
E
L
Site 34
T219
R
A
D
V
D
A
A
T
L
A
R
I
D
L
E
Site 35
S231
D
L
E
R
R
I
E
S
L
N
E
E
I
A
F
Site 36
S266
V
Q
V
E
M
D
M
S
K
P
D
L
T
A
A
Site 37
T271
D
M
S
K
P
D
L
T
A
A
L
R
D
I
R
Site 38
Y281
L
R
D
I
R
A
Q
Y
E
T
I
A
A
K
N
Site 39
T283
D
I
R
A
Q
Y
E
T
I
A
A
K
N
I
S
Site 40
Y296
I
S
E
A
E
E
W
Y
K
S
K
V
S
D
L
Site 41
S298
E
A
E
E
W
Y
K
S
K
V
S
D
L
T
Q
Site 42
T304
K
S
K
V
S
D
L
T
Q
A
A
N
K
N
N
Site 43
Y324
A
K
Q
E
M
M
E
Y
R
H
Q
I
Q
S
Y
Site 44
S330
E
Y
R
H
Q
I
Q
S
Y
T
C
E
I
D
A
Site 45
Y331
Y
R
H
Q
I
Q
S
Y
T
C
E
I
D
A
L
Site 46
T332
R
H
Q
I
Q
S
Y
T
C
E
I
D
A
L
K
Site 47
S344
A
L
K
G
T
N
D
S
L
M
R
Q
M
R
E
Site 48
S358
E
L
E
D
R
F
A
S
E
A
S
G
Y
Q
D
Site 49
Y363
F
A
S
E
A
S
G
Y
Q
D
N
I
A
R
L
Site 50
Y388
M
A
R
H
L
R
E
Y
Q
D
L
L
N
V
K
Site 51
Y405
L
D
V
E
I
A
T
Y
R
K
L
L
E
G
E
Site 52
S414
K
L
L
E
G
E
E
S
R
I
N
L
P
I
Q
Site 53
T422
R
I
N
L
P
I
Q
T
Y
S
A
L
N
F
R
Site 54
Y423
I
N
L
P
I
Q
T
Y
S
A
L
N
F
R
E
Site 55
S424
N
L
P
I
Q
T
Y
S
A
L
N
F
R
E
T
Site 56
T431
S
A
L
N
F
R
E
T
S
P
E
Q
R
G
S
Site 57
S432
A
L
N
F
R
E
T
S
P
E
Q
R
G
S
E
Site 58
S438
T
S
P
E
Q
R
G
S
E
V
H
T
K
K
T
Site 59
T445
S
E
V
H
T
K
K
T
V
M
I
K
T
I
E
Site 60
T450
K
K
T
V
M
I
K
T
I
E
T
R
D
G
E
Site 61
S460
T
R
D
G
E
V
V
S
E
A
T
Q
Q
Q
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation