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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
AMD1
Full Name:
S-adenosylmethionine decarboxylase proenzyme
Alias:
Adenosylmethionine decarboxylase 1; AdoMetDC; AMD; DCAM; EC 4.1.1.50; S-adenosylmethionine decarboxylase 1; SamDC
Type:
Enzyme - Decarboxylase
Mass (Da):
38340
Number AA:
334
UniProt ID:
P17707
International Prot ID:
IPI00016708
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0004014
PhosphoSite+
KinaseNET
Biological Process:
GO:0008295
GO:0006597
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S19
K
L
L
E
V
W
F
S
R
Q
Q
P
D
A
N
Site 2
T34
Q
G
S
G
D
L
R
T
I
P
R
S
E
W
D
Site 3
S38
D
L
R
T
I
P
R
S
E
W
D
I
L
L
K
Site 4
S50
L
L
K
D
V
Q
C
S
I
I
S
V
T
K
T
Site 5
S53
D
V
Q
C
S
I
I
S
V
T
K
T
D
K
Q
Site 6
T57
S
I
I
S
V
T
K
T
D
K
Q
E
A
Y
V
Site 7
Y63
K
T
D
K
Q
E
A
Y
V
L
S
E
S
S
M
Site 8
S66
K
Q
E
A
Y
V
L
S
E
S
S
M
F
V
S
Site 9
S68
E
A
Y
V
L
S
E
S
S
M
F
V
S
K
R
Site 10
S73
S
E
S
S
M
F
V
S
K
R
R
F
I
L
K
Site 11
Y101
L
L
K
L
A
R
D
Y
S
G
F
D
S
I
Q
Site 12
S102
L
K
L
A
R
D
Y
S
G
F
D
S
I
Q
S
Site 13
S106
R
D
Y
S
G
F
D
S
I
Q
S
F
F
Y
S
Site 14
S109
S
G
F
D
S
I
Q
S
F
F
Y
S
R
K
N
Site 15
Y112
D
S
I
Q
S
F
F
Y
S
R
K
N
F
M
K
Site 16
S113
S
I
Q
S
F
F
Y
S
R
K
N
F
M
K
P
Site 17
Y125
M
K
P
S
H
Q
G
Y
P
H
R
N
F
Q
E
Site 18
Y160
N
S
D
C
W
Y
L
Y
T
L
D
F
P
E
S
Site 19
S167
Y
T
L
D
F
P
E
S
R
V
I
S
Q
P
D
Site 20
S171
F
P
E
S
R
V
I
S
Q
P
D
Q
T
L
E
Site 21
T176
V
I
S
Q
P
D
Q
T
L
E
I
L
M
S
E
Site 22
Y193
P
A
V
M
D
Q
F
Y
M
K
D
G
V
T
A
Site 23
T204
G
V
T
A
K
D
V
T
R
E
S
G
I
R
D
Site 24
S207
A
K
D
V
T
R
E
S
G
I
R
D
L
I
P
Site 25
Y239
G
M
K
S
D
G
T
Y
W
T
I
H
I
T
P
Site 26
T241
K
S
D
G
T
Y
W
T
I
H
I
T
P
E
P
Site 27
T245
T
Y
W
T
I
H
I
T
P
E
P
E
F
S
Y
Site 28
S251
I
T
P
E
P
E
F
S
Y
V
S
F
E
T
N
Site 29
Y252
T
P
E
P
E
F
S
Y
V
S
F
E
T
N
L
Site 30
S254
E
P
E
F
S
Y
V
S
F
E
T
N
L
S
Q
Site 31
S260
V
S
F
E
T
N
L
S
Q
T
S
Y
D
D
L
Site 32
Y264
T
N
L
S
Q
T
S
Y
D
D
L
I
R
K
V
Site 33
T283
K
P
G
K
F
V
T
T
L
F
V
N
Q
S
S
Site 34
T294
N
Q
S
S
K
C
R
T
V
L
A
S
P
Q
K
Site 35
S298
K
C
R
T
V
L
A
S
P
Q
K
I
E
G
F
Site 36
Y318
Q
S
A
M
F
N
D
Y
N
F
V
F
T
S
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation