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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PU.1
Full Name:
Transcription factor PU.1
Alias:
31 kDa transforming protein; 31 kDa-transforming protein; Hematopoietic transcription factor PU.1; OF; SFPI1; SPI1; SPI-1; SPI-1 proto-oncogene; SPI-A; Spleen focus forming virus (SFFV) proviral integration oncogene spi1
Type:
Transcription protein
Mass (Da):
31083
Number AA:
270
UniProt ID:
P17947
International Prot ID:
IPI00018333
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003723
GO:0005515
GO:0043565
PhosphoSite+
KinaseNET
Biological Process:
GO:0000122
GO:0043193
GO:0045646
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S17
F
P
L
V
P
P
P
S
E
D
L
V
P
Y
D
Site 2
Y23
P
S
E
D
L
V
P
Y
D
T
D
L
Y
Q
R
Site 3
T25
E
D
L
V
P
Y
D
T
D
L
Y
Q
R
Q
T
Site 4
Y28
V
P
Y
D
T
D
L
Y
Q
R
Q
T
H
E
Y
Site 5
T32
T
D
L
Y
Q
R
Q
T
H
E
Y
Y
P
Y
L
Site 6
Y35
Y
Q
R
Q
T
H
E
Y
Y
P
Y
L
S
S
D
Site 7
Y36
Q
R
Q
T
H
E
Y
Y
P
Y
L
S
S
D
G
Site 8
Y38
Q
T
H
E
Y
Y
P
Y
L
S
S
D
G
E
S
Site 9
S40
H
E
Y
Y
P
Y
L
S
S
D
G
E
S
H
S
Site 10
S41
E
Y
Y
P
Y
L
S
S
D
G
E
S
H
S
D
Site 11
S45
Y
L
S
S
D
G
E
S
H
S
D
H
Y
W
D
Site 12
S64
H
V
H
S
E
F
E
S
F
A
E
N
N
F
T
Site 13
T71
S
F
A
E
N
N
F
T
E
L
Q
S
V
Q
P
Site 14
Y85
P
P
Q
L
Q
Q
L
Y
R
H
M
E
L
E
Q
Site 15
T98
E
Q
M
H
V
L
D
T
P
M
V
P
P
H
P
Site 16
S106
P
M
V
P
P
H
P
S
L
G
H
Q
V
S
Y
Site 17
Y113
S
L
G
H
Q
V
S
Y
L
P
R
M
C
L
Q
Site 18
Y121
L
P
R
M
C
L
Q
Y
P
S
L
S
P
A
Q
Site 19
S123
R
M
C
L
Q
Y
P
S
L
S
P
A
Q
P
S
Site 20
S125
C
L
Q
Y
P
S
L
S
P
A
Q
P
S
S
D
Site 21
S130
S
L
S
P
A
Q
P
S
S
D
E
E
E
G
E
Site 22
S131
L
S
P
A
Q
P
S
S
D
E
E
E
G
E
R
Site 23
S140
E
E
E
G
E
R
Q
S
P
P
L
E
V
S
D
Site 24
S146
Q
S
P
P
L
E
V
S
D
G
E
A
D
G
L
Site 25
T164
P
G
L
L
P
G
E
T
G
S
K
K
K
I
R
Site 26
S166
L
L
P
G
E
T
G
S
K
K
K
I
R
L
Y
Site 27
Y173
S
K
K
K
I
R
L
Y
Q
F
L
L
D
L
L
Site 28
T198
W
V
D
K
D
K
G
T
F
Q
F
S
S
K
H
Site 29
Y225
G
N
R
K
K
M
T
Y
Q
K
M
A
R
A
L
Site 30
Y235
M
A
R
A
L
R
N
Y
G
K
T
G
E
V
K
Site 31
T238
A
L
R
N
Y
G
K
T
G
E
V
K
K
V
K
Site 32
T249
K
K
V
K
K
K
L
T
Y
Q
F
S
G
E
V
Site 33
S253
K
K
L
T
Y
Q
F
S
G
E
V
L
G
R
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation