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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PTP1B
Full Name:
Tyrosine-protein phosphatase non-receptor type 1
Alias:
CPTP1; EC 3.1.3.48; HA2; Protein tyrosine phosphatase, non-receptor type 1; Protein-protein-tyrosine phosphatase HA2; Protein-tyrosine phosphatase 1B; Protein-tyrosine phosphatase, non-receptor type 1; PTN1; PTP-1B; PTP-HA2; PTPN1
Type:
Phosphatase; EC 3.1.3.48; Protein phosphatase, tyrosine (non-receptor)
Mass (Da):
49967
Number AA:
435
UniProt ID:
P18031
International Prot ID:
IPI00297261
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005783
GO:0016020
Uniprot
OncoNet
Molecular Function:
GO:0004725
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0046627
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S15
E
Q
I
D
K
S
G
S
W
A
A
I
Y
Q
D
Site 2
Y20
S
G
S
W
A
A
I
Y
Q
D
I
R
H
E
A
Site 3
S28
Q
D
I
R
H
E
A
S
D
F
P
C
R
V
A
Site 4
Y46
K
N
K
N
R
N
R
Y
R
D
V
S
P
F
D
Site 5
S50
R
N
R
Y
R
D
V
S
P
F
D
H
S
R
I
Site 6
S55
D
V
S
P
F
D
H
S
R
I
K
L
H
Q
E
Site 7
Y66
L
H
Q
E
D
N
D
Y
I
N
A
S
L
I
K
Site 8
S70
D
N
D
Y
I
N
A
S
L
I
K
M
E
E
A
Site 9
S80
K
M
E
E
A
Q
R
S
Y
I
L
T
Q
G
P
Site 10
Y81
M
E
E
A
Q
R
S
Y
I
L
T
Q
G
P
L
Site 11
T84
A
Q
R
S
Y
I
L
T
Q
G
P
L
P
N
T
Site 12
S118
N
R
V
M
E
K
G
S
L
K
C
A
Q
Y
W
Site 13
Y124
G
S
L
K
C
A
Q
Y
W
P
Q
K
E
E
K
Site 14
T143
E
D
T
N
L
K
L
T
L
I
S
E
D
I
K
Site 15
S146
N
L
K
L
T
L
I
S
E
D
I
K
S
Y
Y
Site 16
S151
L
I
S
E
D
I
K
S
Y
Y
T
V
R
Q
L
Site 17
Y152
I
S
E
D
I
K
S
Y
Y
T
V
R
Q
L
E
Site 18
Y153
S
E
D
I
K
S
Y
Y
T
V
R
Q
L
E
L
Site 19
T154
E
D
I
K
S
Y
Y
T
V
R
Q
L
E
L
E
Site 20
T165
L
E
L
E
N
L
T
T
Q
E
T
R
E
I
L
Site 21
S187
P
D
F
G
V
P
E
S
P
A
S
F
L
N
F
Site 22
S201
F
L
F
K
V
R
E
S
G
S
L
S
P
E
H
Site 23
S203
F
K
V
R
E
S
G
S
L
S
P
E
H
G
P
Site 24
S205
V
R
E
S
G
S
L
S
P
E
H
G
P
V
V
Site 25
S242
M
D
K
R
K
D
P
S
S
V
D
I
K
K
V
Site 26
S243
D
K
R
K
D
P
S
S
V
D
I
K
K
V
L
Site 27
Y271
A
D
Q
L
R
F
S
Y
L
A
V
I
E
G
A
Site 28
S295
Q
D
Q
W
K
E
L
S
H
E
D
L
E
P
P
Site 29
S352
P
I
K
E
E
K
G
S
P
L
N
A
A
P
Y
Site 30
Y359
S
P
L
N
A
A
P
Y
G
I
E
S
M
S
Q
Site 31
S363
A
A
P
Y
G
I
E
S
M
S
Q
D
T
E
V
Site 32
S365
P
Y
G
I
E
S
M
S
Q
D
T
E
V
R
S
Site 33
T368
I
E
S
M
S
Q
D
T
E
V
R
S
R
V
V
Site 34
S372
S
Q
D
T
E
V
R
S
R
V
V
G
G
S
L
Site 35
S378
R
S
R
V
V
G
G
S
L
R
G
A
Q
A
A
Site 36
S386
L
R
G
A
Q
A
A
S
P
A
K
G
E
P
S
Site 37
S393
S
P
A
K
G
E
P
S
L
P
E
K
D
E
D
Site 38
Y405
D
E
D
H
A
L
S
Y
W
K
P
F
L
V
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation