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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ALOX12
Full Name:
Arachidonate 12-lipoxygenase, 12S-type
Alias:
Platelet-type lipoxygenase 12
Type:
Mass (Da):
75694
Number AA:
663
UniProt ID:
P18054
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T10
R
Y
R
I
R
V
A
T
G
A
W
L
F
S
G
Site 2
Y97
A
E
V
A
F
P
C
Y
R
W
V
Q
G
E
D
Site 3
S107
V
Q
G
E
D
I
L
S
L
P
E
G
T
A
R
Site 4
T151
W
K
E
G
L
P
L
T
I
A
A
D
R
K
D
Site 5
Y191
E
M
A
L
K
R
V
Y
T
L
L
S
S
W
N
Site 6
S212
Q
I
F
W
G
Q
K
S
A
L
A
E
K
V
R
Site 7
Y230
Q
D
D
E
L
F
S
Y
Q
F
L
N
G
A
N
Site 8
S244
N
P
M
L
L
R
R
S
T
S
L
P
S
R
L
Site 9
T245
P
M
L
L
R
R
S
T
S
L
P
S
R
L
V
Site 10
S246
M
L
L
R
R
S
T
S
L
P
S
R
L
V
L
Site 11
S249
R
R
S
T
S
L
P
S
R
L
V
L
P
S
G
Site 12
S255
P
S
R
L
V
L
P
S
G
M
E
E
L
Q
A
Site 13
S325
I
Q
P
P
N
P
S
S
P
T
P
T
L
F
L
Site 14
T327
P
P
N
P
S
S
P
T
P
T
L
F
L
P
S
Site 15
T329
N
P
S
S
P
T
P
T
L
F
L
P
S
D
P
Site 16
S350
A
K
S
W
V
R
N
S
D
F
Q
L
H
E
I
Site 17
Y359
F
Q
L
H
E
I
Q
Y
H
L
L
N
T
H
L
Site 18
Y395
F
L
I
P
H
I
R
Y
T
M
E
I
N
T
R
Site 19
T396
L
I
P
H
I
R
Y
T
M
E
I
N
T
R
A
Site 20
T405
E
I
N
T
R
A
R
T
Q
L
I
S
D
G
G
Site 21
S409
R
A
R
T
Q
L
I
S
D
G
G
I
F
D
K
Site 22
T437
R
R
A
A
A
Q
L
T
Y
C
S
L
C
P
P
Site 23
Y438
R
A
A
A
Q
L
T
Y
C
S
L
C
P
P
D
Site 24
Y483
E
G
I
V
H
L
F
Y
Q
R
D
D
I
V
K
Site 25
S518
Q
D
R
G
F
P
V
S
F
Q
S
Q
S
Q
L
Site 26
S521
G
F
P
V
S
F
Q
S
Q
S
Q
L
C
H
F
Site 27
S523
P
V
S
F
Q
S
Q
S
Q
L
C
H
F
L
T
Site 28
Y551
N
Q
G
Q
L
D
W
Y
A
W
V
P
N
A
P
Site 29
T567
T
M
R
M
P
P
P
T
T
K
E
D
V
T
M
Site 30
T573
P
T
T
K
E
D
V
T
M
A
T
V
M
G
S
Site 31
T576
K
E
D
V
T
M
A
T
V
M
G
S
L
P
D
Site 32
Y614
L
G
H
H
K
E
K
Y
F
S
G
P
K
P
K
Site 33
S616
H
H
K
E
K
Y
F
S
G
P
K
P
K
A
V
Site 34
T639
E
K
L
E
K
E
I
T
A
R
N
E
Q
L
D
Site 35
Y649
N
E
Q
L
D
W
P
Y
E
Y
L
K
P
S
C
Site 36
Y651
Q
L
D
W
P
Y
E
Y
L
K
P
S
C
I
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation