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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ERCC2
Full Name:
TFIIH basal transcription factor complex helicase XPD subunit
Alias:
Basic transcription factor 2 80 kDa subunit;CXPD;DNA excision repair protein ERCC-2;DNA repair protein complementing XP-D cells;TFIIH basal transcription factor complex 80 kDa subunit;Xeroderma pigmentosum group D-complementing protein
Type:
Mass (Da):
86909
Number AA:
760
UniProt ID:
P18074
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y14
G
L
L
V
Y
F
P
Y
D
Y
I
Y
P
E
Q
Site 2
Y16
L
V
Y
F
P
Y
D
Y
I
Y
P
E
Q
F
S
Site 3
Y18
Y
F
P
Y
D
Y
I
Y
P
E
Q
F
S
Y
M
Site 4
Y24
I
Y
P
E
Q
F
S
Y
M
R
E
L
K
R
T
Site 5
T31
Y
M
R
E
L
K
R
T
L
D
A
K
G
H
G
Site 6
S44
H
G
V
L
E
M
P
S
G
T
G
K
T
V
S
Site 7
T76
K
L
I
Y
C
S
R
T
V
P
E
I
E
K
V
Site 8
Y94
L
R
K
L
L
N
F
Y
E
K
Q
E
G
E
K
Site 9
T122
L
C
I
H
P
E
V
T
P
L
R
F
G
K
D
Site 10
S136
D
V
D
G
K
C
H
S
L
T
A
S
Y
V
R
Site 11
T138
D
G
K
C
H
S
L
T
A
S
Y
V
R
A
Q
Site 12
S140
K
C
H
S
L
T
A
S
Y
V
R
A
Q
Y
Q
Site 13
Y141
C
H
S
L
T
A
S
Y
V
R
A
Q
Y
Q
H
Site 14
Y146
A
S
Y
V
R
A
Q
Y
Q
H
D
T
S
L
P
Site 15
Y158
S
L
P
H
C
R
F
Y
E
E
F
D
A
H
G
Site 16
Y175
V
P
L
P
A
G
I
Y
N
L
D
D
L
K
A
Site 17
Y192
R
R
Q
G
W
C
P
Y
F
L
A
R
Y
S
I
Site 18
S222
P
K
I
A
D
L
V
S
K
E
L
A
R
K
A
Site 19
S248
N
V
C
I
D
S
M
S
V
N
L
T
R
R
T
Site 20
T252
D
S
M
S
V
N
L
T
R
R
T
L
D
R
C
Site 21
T255
S
V
N
L
T
R
R
T
L
D
R
C
Q
G
N
Site 22
T269
N
L
E
T
L
Q
K
T
V
L
R
I
K
E
T
Site 23
Y285
E
Q
R
L
R
D
E
Y
R
R
L
V
E
G
L
Site 24
S296
V
E
G
L
R
E
A
S
A
A
R
E
T
D
A
Site 25
T301
E
A
S
A
A
R
E
T
D
A
H
L
A
N
P
Site 26
S322
L
Q
E
A
V
P
G
S
I
R
T
A
E
H
F
Site 27
Y339
F
L
R
R
L
L
E
Y
V
K
W
R
L
R
V
Site 28
S353
V
Q
H
V
V
Q
E
S
P
P
A
F
L
S
G
Site 29
T425
I
E
P
F
D
D
R
T
P
T
I
A
N
P
I
Site 30
T427
P
F
D
D
R
T
P
T
I
A
N
P
I
L
H
Site 31
T548
S
Y
Q
Y
M
E
S
T
V
A
S
W
Y
E
Q
Site 32
Y553
E
S
T
V
A
S
W
Y
E
Q
G
I
L
E
N
Site 33
S578
T
Q
D
G
A
E
T
S
V
A
L
E
K
Y
Q
Site 34
Y584
T
S
V
A
L
E
K
Y
Q
E
A
C
E
N
G
Site 35
S605
S
V
A
R
G
K
V
S
E
G
I
D
F
V
H
Site 36
Y639
I
L
K
A
R
L
E
Y
L
R
D
Q
F
Q
I
Site 37
T653
I
R
E
N
D
F
L
T
F
D
A
M
R
H
A
Site 38
T672
G
R
A
I
R
G
K
T
D
Y
G
L
M
V
F
Site 39
T702
R
W
I
Q
E
H
L
T
D
A
N
L
N
L
T
Site 40
T709
T
D
A
N
L
N
L
T
V
D
E
G
V
Q
V
Site 41
Y719
E
G
V
Q
V
A
K
Y
F
L
R
Q
M
A
Q
Site 42
S737
R
E
D
Q
L
G
L
S
L
L
S
L
E
Q
L
Site 43
S740
Q
L
G
L
S
L
L
S
L
E
Q
L
E
S
E
Site 44
S746
L
S
L
E
Q
L
E
S
E
E
T
L
K
R
I
Site 45
T749
E
Q
L
E
S
E
E
T
L
K
R
I
E
Q
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation