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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Egr1
Full Name:
Early growth response protein 1
Alias:
AT225; Early growth response 1; EGR-1; G0S30; KROX-24; Krox-24 protein; Nerve growth factor-induced protein A; NGFI-A; TIS8; Transcription factor ETR103; ZIF268; ZIF-268; Zinc finger protein 225; ZNF225
Type:
Transcription factor
Mass (Da):
57507
Number AA:
543
UniProt ID:
P18146
International Prot ID:
IPI00030227
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0003700
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
K
A
E
M
Q
L
M
S
P
L
Q
I
S
D
P
Site 2
S22
Q
I
S
D
P
F
G
S
F
P
H
S
P
T
M
Site 3
S26
P
F
G
S
F
P
H
S
P
T
M
D
N
Y
P
Site 4
T28
G
S
F
P
H
S
P
T
M
D
N
Y
P
K
L
Site 5
Y32
H
S
P
T
M
D
N
Y
P
K
L
E
E
M
M
Site 6
S58
A
A
G
A
P
E
G
S
G
S
N
S
S
S
S
Site 7
S60
G
A
P
E
G
S
G
S
N
S
S
S
S
S
S
Site 8
S62
P
E
G
S
G
S
N
S
S
S
S
S
S
G
G
Site 9
S63
E
G
S
G
S
N
S
S
S
S
S
S
G
G
G
Site 10
S64
G
S
G
S
N
S
S
S
S
S
S
G
G
G
G
Site 11
S65
S
G
S
N
S
S
S
S
S
S
G
G
G
G
G
Site 12
S66
G
S
N
S
S
S
S
S
S
G
G
G
G
G
G
Site 13
S67
S
N
S
S
S
S
S
S
G
G
G
G
G
G
G
Site 14
S77
G
G
G
G
G
G
G
S
N
S
S
S
S
S
S
Site 15
S79
G
G
G
G
G
S
N
S
S
S
S
S
S
T
F
Site 16
S80
G
G
G
G
S
N
S
S
S
S
S
S
T
F
N
Site 17
S81
G
G
G
S
N
S
S
S
S
S
S
T
F
N
P
Site 18
S82
G
G
S
N
S
S
S
S
S
S
T
F
N
P
Q
Site 19
S83
G
S
N
S
S
S
S
S
S
T
F
N
P
Q
A
Site 20
S84
S
N
S
S
S
S
S
S
T
F
N
P
Q
A
D
Site 21
T85
N
S
S
S
S
S
S
T
F
N
P
Q
A
D
T
Site 22
T101
E
Q
P
Y
E
H
L
T
A
E
S
F
P
D
I
Site 23
S104
Y
E
H
L
T
A
E
S
F
P
D
I
S
L
N
Site 24
S109
A
E
S
F
P
D
I
S
L
N
N
E
K
V
L
Site 25
S120
E
K
V
L
V
E
T
S
Y
P
S
Q
T
T
R
Site 26
Y121
K
V
L
V
E
T
S
Y
P
S
Q
T
T
R
L
Site 27
T125
E
T
S
Y
P
S
Q
T
T
R
L
P
P
I
T
Site 28
T132
T
T
R
L
P
P
I
T
Y
T
G
R
F
S
L
Site 29
Y133
T
R
L
P
P
I
T
Y
T
G
R
F
S
L
E
Site 30
T134
R
L
P
P
I
T
Y
T
G
R
F
S
L
E
P
Site 31
S138
I
T
Y
T
G
R
F
S
L
E
P
A
P
N
S
Site 32
S145
S
L
E
P
A
P
N
S
G
N
T
L
W
P
E
Site 33
T148
P
A
P
N
S
G
N
T
L
W
P
E
P
L
F
Site 34
T165
V
S
G
L
V
S
M
T
N
P
P
A
S
S
S
Site 35
S170
S
M
T
N
P
P
A
S
S
S
S
A
P
S
P
Site 36
S171
M
T
N
P
P
A
S
S
S
S
A
P
S
P
A
Site 37
S172
T
N
P
P
A
S
S
S
S
A
P
S
P
A
A
Site 38
S173
N
P
P
A
S
S
S
S
A
P
S
P
A
A
S
Site 39
S176
A
S
S
S
S
A
P
S
P
A
A
S
S
A
S
Site 40
S180
S
A
P
S
P
A
A
S
S
A
S
A
S
Q
S
Site 41
S181
A
P
S
P
A
A
S
S
A
S
A
S
Q
S
P
Site 42
S183
S
P
A
A
S
S
A
S
A
S
Q
S
P
P
L
Site 43
S185
A
A
S
S
A
S
A
S
Q
S
P
P
L
S
C
Site 44
S187
S
S
A
S
A
S
Q
S
P
P
L
S
C
A
V
Site 45
S191
A
S
Q
S
P
P
L
S
C
A
V
P
S
N
D
Site 46
S196
P
L
S
C
A
V
P
S
N
D
S
S
P
I
Y
Site 47
S200
A
V
P
S
N
D
S
S
P
I
Y
S
A
A
P
Site 48
Y203
S
N
D
S
S
P
I
Y
S
A
A
P
T
F
P
Site 49
S204
N
D
S
S
P
I
Y
S
A
A
P
T
F
P
T
Site 50
T208
P
I
Y
S
A
A
P
T
F
P
T
P
N
T
D
Site 51
T211
S
A
A
P
T
F
P
T
P
N
T
D
I
F
P
Site 52
T214
P
T
F
P
T
P
N
T
D
I
F
P
E
P
Q
Site 53
S222
D
I
F
P
E
P
Q
S
Q
A
F
P
G
S
A
Site 54
S228
Q
S
Q
A
F
P
G
S
A
G
T
A
L
Q
Y
Site 55
Y235
S
A
G
T
A
L
Q
Y
P
P
P
A
Y
P
A
Site 56
Y240
L
Q
Y
P
P
P
A
Y
P
A
A
K
G
G
F
Site 57
Y255
Q
V
P
M
I
P
D
Y
L
F
P
Q
Q
Q
G
Site 58
T268
Q
G
D
L
G
L
G
T
P
D
Q
K
P
F
Q
Site 59
S279
K
P
F
Q
G
L
E
S
R
T
Q
Q
P
S
L
Site 60
T281
F
Q
G
L
E
S
R
T
Q
Q
P
S
L
T
P
Site 61
S285
E
S
R
T
Q
Q
P
S
L
T
P
L
S
T
I
Site 62
T287
R
T
Q
Q
P
S
L
T
P
L
S
T
I
K
A
Site 63
T297
S
T
I
K
A
F
A
T
Q
S
G
S
Q
D
L
Site 64
S301
A
F
A
T
Q
S
G
S
Q
D
L
K
A
L
N
Site 65
T309
Q
D
L
K
A
L
N
T
S
Y
Q
S
Q
L
I
Site 66
S313
A
L
N
T
S
Y
Q
S
Q
L
I
K
P
S
R
Site 67
Y324
K
P
S
R
M
R
K
Y
P
N
R
P
S
K
T
Site 68
S329
R
K
Y
P
N
R
P
S
K
T
P
P
H
E
R
Site 69
T331
Y
P
N
R
P
S
K
T
P
P
H
E
R
P
Y
Site 70
Y338
T
P
P
H
E
R
P
Y
A
C
P
V
E
S
C
Site 71
S344
P
Y
A
C
P
V
E
S
C
D
R
R
F
S
R
Site 72
S350
E
S
C
D
R
R
F
S
R
S
D
E
L
T
R
Site 73
S352
C
D
R
R
F
S
R
S
D
E
L
T
R
H
I
Site 74
T356
F
S
R
S
D
E
L
T
R
H
I
R
I
H
T
Site 75
T363
T
R
H
I
R
I
H
T
G
Q
K
P
F
Q
C
Site 76
S378
R
I
C
M
R
N
F
S
R
S
D
H
L
T
T
Site 77
T384
F
S
R
S
D
H
L
T
T
H
I
R
T
H
T
Site 78
T385
S
R
S
D
H
L
T
T
H
I
R
T
H
T
G
Site 79
T389
H
L
T
T
H
I
R
T
H
T
G
E
K
P
F
Site 80
T391
T
T
H
I
R
T
H
T
G
E
K
P
F
A
C
Site 81
S408
C
G
R
K
F
A
R
S
D
E
R
K
R
H
T
Site 82
T415
S
D
E
R
K
R
H
T
K
I
H
L
R
Q
K
Site 83
S429
K
D
K
K
A
D
K
S
V
V
A
S
S
A
T
Site 84
S433
A
D
K
S
V
V
A
S
S
A
T
S
S
L
S
Site 85
S434
D
K
S
V
V
A
S
S
A
T
S
S
L
S
S
Site 86
S438
V
A
S
S
A
T
S
S
L
S
S
Y
P
S
P
Site 87
S440
S
S
A
T
S
S
L
S
S
Y
P
S
P
V
A
Site 88
S441
S
A
T
S
S
L
S
S
Y
P
S
P
V
A
T
Site 89
Y442
A
T
S
S
L
S
S
Y
P
S
P
V
A
T
S
Site 90
S444
S
S
L
S
S
Y
P
S
P
V
A
T
S
Y
P
Site 91
T448
S
Y
P
S
P
V
A
T
S
Y
P
S
P
V
T
Site 92
Y450
P
S
P
V
A
T
S
Y
P
S
P
V
T
T
S
Site 93
S452
P
V
A
T
S
Y
P
S
P
V
T
T
S
Y
P
Site 94
T455
T
S
Y
P
S
P
V
T
T
S
Y
P
S
P
A
Site 95
T456
S
Y
P
S
P
V
T
T
S
Y
P
S
P
A
T
Site 96
S457
Y
P
S
P
V
T
T
S
Y
P
S
P
A
T
T
Site 97
Y458
P
S
P
V
T
T
S
Y
P
S
P
A
T
T
S
Site 98
S460
P
V
T
T
S
Y
P
S
P
A
T
T
S
Y
P
Site 99
T463
T
S
Y
P
S
P
A
T
T
S
Y
P
S
P
V
Site 100
T464
S
Y
P
S
P
A
T
T
S
Y
P
S
P
V
P
Site 101
S465
Y
P
S
P
A
T
T
S
Y
P
S
P
V
P
T
Site 102
Y466
P
S
P
A
T
T
S
Y
P
S
P
V
P
T
S
Site 103
S468
P
A
T
T
S
Y
P
S
P
V
P
T
S
F
S
Site 104
T472
S
Y
P
S
P
V
P
T
S
F
S
S
P
G
S
Site 105
S473
Y
P
S
P
V
P
T
S
F
S
S
P
G
S
S
Site 106
S475
S
P
V
P
T
S
F
S
S
P
G
S
S
T
Y
Site 107
S476
P
V
P
T
S
F
S
S
P
G
S
S
T
Y
P
Site 108
S479
T
S
F
S
S
P
G
S
S
T
Y
P
S
P
V
Site 109
S480
S
F
S
S
P
G
S
S
T
Y
P
S
P
V
H
Site 110
T481
F
S
S
P
G
S
S
T
Y
P
S
P
V
H
S
Site 111
Y482
S
S
P
G
S
S
T
Y
P
S
P
V
H
S
G
Site 112
S484
P
G
S
S
T
Y
P
S
P
V
H
S
G
F
P
Site 113
S488
T
Y
P
S
P
V
H
S
G
F
P
S
P
S
V
Site 114
S492
P
V
H
S
G
F
P
S
P
S
V
A
T
T
Y
Site 115
S494
H
S
G
F
P
S
P
S
V
A
T
T
Y
S
S
Site 116
T498
P
S
P
S
V
A
T
T
Y
S
S
V
P
P
A
Site 117
S515
A
Q
V
S
S
F
P
S
S
A
V
T
N
S
F
Site 118
S516
Q
V
S
S
F
P
S
S
A
V
T
N
S
F
S
Site 119
T519
S
F
P
S
S
A
V
T
N
S
F
S
A
S
T
Site 120
S521
P
S
S
A
V
T
N
S
F
S
A
S
T
G
L
Site 121
S523
S
A
V
T
N
S
F
S
A
S
T
G
L
S
D
Site 122
S525
V
T
N
S
F
S
A
S
T
G
L
S
D
M
T
Site 123
T532
S
T
G
L
S
D
M
T
A
T
F
S
P
R
T
Site 124
T534
G
L
S
D
M
T
A
T
F
S
P
R
T
I
E
Site 125
S536
S
D
M
T
A
T
F
S
P
R
T
I
E
I
C
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation