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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
VCL
Full Name:
Vinculin
Alias:
Metavinculin; VCL, VINC
Type:
Adhesion, cytoskeletal protein
Mass (Da):
123799
Number AA:
1134
UniProt ID:
P18206
International Prot ID:
IPI00291175
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0015629
GO:0043034
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0003779
GO:0045294
GO:0016491
PhosphoSite+
KinaseNET
Biological Process:
GO:0043297
GO:0007155
GO:0006928
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T61
L
V
R
V
G
K
E
T
V
Q
T
T
E
D
Q
Site 2
T64
V
G
K
E
T
V
Q
T
T
E
D
Q
I
L
K
Site 3
S97
Q
A
A
Q
M
L
Q
S
D
P
Y
S
V
P
A
Site 4
Y100
Q
M
L
Q
S
D
P
Y
S
V
P
A
R
D
Y
Site 5
S101
M
L
Q
S
D
P
Y
S
V
P
A
R
D
Y
L
Site 6
Y107
Y
S
V
P
A
R
D
Y
L
I
D
G
S
R
G
Site 7
S112
R
D
Y
L
I
D
G
S
R
G
I
L
S
G
T
Site 8
T125
G
T
S
D
L
L
L
T
F
D
E
A
E
V
R
Site 9
T159
E
T
M
E
D
L
V
T
Y
T
K
N
L
G
P
Site 10
Y160
T
M
E
D
L
V
T
Y
T
K
N
L
G
P
G
Site 11
T183
D
E
R
Q
Q
E
L
T
H
Q
E
H
R
V
M
Site 12
T214
S
A
M
K
I
F
V
T
T
K
N
S
K
N
Q
Site 13
T233
A
L
K
N
R
N
F
T
V
E
K
M
S
A
E
Site 14
T251
I
I
R
V
L
Q
L
T
S
W
D
E
D
A
W
Site 15
S260
W
D
E
D
A
W
A
S
K
D
T
E
A
M
K
Site 16
S272
A
M
K
R
A
L
A
S
I
D
S
K
L
N
Q
Site 17
S275
R
A
L
A
S
I
D
S
K
L
N
Q
A
K
G
Site 18
S288
K
G
W
L
R
D
P
S
A
S
P
G
D
A
G
Site 19
S290
W
L
R
D
P
S
A
S
P
G
D
A
G
E
Q
Site 20
T324
E
R
R
E
I
L
G
T
C
K
M
L
G
Q
M
Site 21
S346
R
A
R
G
Q
G
S
S
P
V
A
M
Q
K
A
Site 22
S357
M
Q
K
A
Q
Q
V
S
Q
G
L
D
V
L
T
Site 23
S380
K
L
E
A
M
T
N
S
K
Q
S
I
A
K
K
Site 24
S434
E
R
D
D
I
L
R
S
L
G
E
I
S
A
L
Site 25
T442
L
G
E
I
S
A
L
T
S
K
L
A
D
L
R
Site 26
S443
G
E
I
S
A
L
T
S
K
L
A
D
L
R
R
Site 27
S456
R
R
Q
G
K
G
D
S
P
E
A
R
A
L
A
Site 28
T477
L
Q
N
L
Q
T
K
T
N
R
A
V
A
N
S
Site 29
S484
T
N
R
A
V
A
N
S
R
P
A
K
A
A
V
Site 30
T508
Q
R
W
I
D
N
P
T
V
D
D
R
G
V
G
Site 31
S566
A
A
R
G
E
G
E
S
P
Q
A
R
A
L
A
Site 32
S574
P
Q
A
R
A
L
A
S
Q
L
Q
D
S
L
K
Site 33
S579
L
A
S
Q
L
Q
D
S
L
K
D
L
K
A
R
Site 34
T592
A
R
M
Q
E
A
M
T
Q
E
V
S
D
V
F
Site 35
S596
E
A
M
T
Q
E
V
S
D
V
F
S
D
T
T
Site 36
S600
Q
E
V
S
D
V
F
S
D
T
T
T
P
I
K
Site 37
T603
S
D
V
F
S
D
T
T
T
P
I
K
L
L
A
Site 38
T604
D
V
F
S
D
T
T
T
P
I
K
L
L
A
V
Site 39
S656
A
V
G
T
A
N
K
S
T
V
E
G
I
Q
A
Site 40
T657
V
G
T
A
N
K
S
T
V
E
G
I
Q
A
S
Site 41
S664
T
V
E
G
I
Q
A
S
V
K
T
A
R
E
L
Site 42
T667
G
I
Q
A
S
V
K
T
A
R
E
L
T
P
Q
Site 43
Y692
N
P
G
N
Q
A
A
Y
E
H
F
E
T
M
K
Site 44
T697
A
A
Y
E
H
F
E
T
M
K
N
Q
W
I
D
Site 45
T719
L
V
D
E
A
I
D
T
K
S
L
L
D
A
S
Site 46
S721
D
E
A
I
D
T
K
S
L
L
D
A
S
E
E
Site 47
S726
T
K
S
L
L
D
A
S
E
E
A
I
K
K
D
Site 48
T754
Q
M
L
V
A
G
A
T
S
I
A
R
R
A
N
Site 49
S774
A
K
R
E
V
E
N
S
E
D
P
K
F
R
E
Site 50
S787
R
E
A
V
K
A
A
S
D
E
L
S
K
T
I
Site 51
S791
K
A
A
S
D
E
L
S
K
T
I
S
P
M
V
Site 52
T793
A
S
D
E
L
S
K
T
I
S
P
M
V
M
D
Site 53
S795
D
E
L
S
K
T
I
S
P
M
V
M
D
A
K
Site 54
S809
K
A
V
A
G
N
I
S
D
P
G
L
Q
K
S
Site 55
S816
S
D
P
G
L
Q
K
S
F
L
D
S
G
Y
R
Site 56
S820
L
Q
K
S
F
L
D
S
G
Y
R
I
L
G
A
Site 57
Y822
K
S
F
L
D
S
G
Y
R
I
L
G
A
V
A
Site 58
T855
D
L
E
Q
L
R
L
T
D
E
L
A
P
P
K
Site 59
S913
H
D
E
A
R
K
W
S
S
K
P
G
I
P
A
Site 60
S914
D
E
A
R
K
W
S
S
K
P
G
I
P
A
A
Site 61
Y949
P
P
D
M
E
D
D
Y
E
P
E
L
L
L
M
Site 62
S958
P
E
L
L
L
M
P
S
N
Q
P
V
N
Q
P
Site 63
S972
P
I
L
A
A
A
Q
S
L
H
R
E
A
T
K
Site 64
T978
Q
S
L
H
R
E
A
T
K
W
S
S
K
G
N
Site 65
S981
H
R
E
A
T
K
W
S
S
K
G
N
D
I
I
Site 66
S1009
S
R
L
V
R
G
G
S
G
T
K
R
A
L
I
Site 67
S1026
A
K
D
I
A
K
A
S
D
E
V
T
R
L
A
Site 68
T1030
A
K
A
S
D
E
V
T
R
L
A
K
E
V
A
Site 69
T1047
C
T
D
K
R
I
R
T
N
L
L
Q
V
C
E
Site 70
T1058
Q
V
C
E
R
I
P
T
I
S
T
Q
L
K
I
Site 71
S1080
M
L
G
R
T
N
I
S
D
E
E
S
E
Q
A
Site 72
S1084
T
N
I
S
D
E
E
S
E
Q
A
T
E
M
L
Site 73
S1101
N
A
Q
N
L
M
Q
S
V
K
E
T
V
R
E
Site 74
T1105
L
M
Q
S
V
K
E
T
V
R
E
A
E
A
A
Site 75
S1113
V
R
E
A
E
A
A
S
I
K
I
R
T
D
A
Site 76
T1123
I
R
T
D
A
G
F
T
L
R
W
V
R
K
T
Site 77
Y1133
W
V
R
K
T
P
W
Y
Q
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation