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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NAT1
Full Name:
Arylamine N-acetyltransferase 1
Alias:
AAC1; ARY1; ARY2; Arylamide acetylase 1; Arylamine N-acetyltransferase; MNAT; Monomorphic arylamine N-acetyltransferase; N-acetyltransferase 1
Type:
EC 2.3.1.5; Xenobiotic Metabolism - drug metabolism - other enzymes; Acetyltransferase; Secondary Metabolites Metabolism - caffeine
Mass (Da):
33900
Number AA:
290
UniProt ID:
P18440
International Prot ID:
IPI00644361
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0004060
PhosphoSite+
KinaseNET
Biological Process:
GO:0008152
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y12
A
Y
L
E
R
I
G
Y
K
K
S
R
N
K
L
Site 2
S15
E
R
I
G
Y
K
K
S
R
N
K
L
D
L
E
Site 3
T23
R
N
K
L
D
L
E
T
L
T
D
I
L
Q
H
Site 4
Y92
E
T
T
M
L
G
G
Y
V
Y
S
T
P
A
K
Site 5
Y94
T
M
L
G
G
Y
V
Y
S
T
P
A
K
K
Y
Site 6
S95
M
L
G
G
Y
V
Y
S
T
P
A
K
K
Y
S
Site 7
T96
L
G
G
Y
V
Y
S
T
P
A
K
K
Y
S
T
Site 8
Y101
Y
S
T
P
A
K
K
Y
S
T
G
M
I
H
L
Site 9
Y129
D
A
G
F
G
R
S
Y
Q
M
W
Q
P
L
E
Site 10
Y160
T
E
E
N
G
F
W
Y
L
D
Q
I
R
R
E
Site 11
Y169
D
Q
I
R
R
E
Q
Y
I
P
N
E
E
F
L
Site 12
S178
P
N
E
E
F
L
H
S
D
L
L
E
D
S
K
Site 13
S184
H
S
D
L
L
E
D
S
K
Y
R
K
I
Y
S
Site 14
Y186
D
L
L
E
D
S
K
Y
R
K
I
Y
S
F
T
Site 15
Y190
D
S
K
Y
R
K
I
Y
S
F
T
L
K
P
R
Site 16
S191
S
K
Y
R
K
I
Y
S
F
T
L
K
P
R
T
Site 17
T193
Y
R
K
I
Y
S
F
T
L
K
P
R
T
I
E
Site 18
T198
S
F
T
L
K
P
R
T
I
E
D
F
E
S
M
Site 19
T207
E
D
F
E
S
M
N
T
Y
L
Q
T
S
P
S
Site 20
Y208
D
F
E
S
M
N
T
Y
L
Q
T
S
P
S
S
Site 21
T211
S
M
N
T
Y
L
Q
T
S
P
S
S
V
F
T
Site 22
S212
M
N
T
Y
L
Q
T
S
P
S
S
V
F
T
S
Site 23
S214
T
Y
L
Q
T
S
P
S
S
V
F
T
S
K
S
Site 24
S215
Y
L
Q
T
S
P
S
S
V
F
T
S
K
S
F
Site 25
T218
T
S
P
S
S
V
F
T
S
K
S
F
C
S
L
Site 26
S219
S
P
S
S
V
F
T
S
K
S
F
C
S
L
Q
Site 27
S221
S
S
V
F
T
S
K
S
F
C
S
L
Q
T
P
Site 28
S224
F
T
S
K
S
F
C
S
L
Q
T
P
D
G
V
Site 29
T227
K
S
F
C
S
L
Q
T
P
D
G
V
H
C
L
Site 30
Y246
L
T
H
R
R
F
N
Y
K
D
N
T
D
L
I
Site 31
T250
R
F
N
Y
K
D
N
T
D
L
I
E
F
K
T
Site 32
T257
T
D
L
I
E
F
K
T
L
S
E
E
E
I
E
Site 33
S259
L
I
E
F
K
T
L
S
E
E
E
I
E
K
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation