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Updated November 2019
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Protein Info
Short Name:
SON
Full Name:
Protein SON
Alias:
BASS1; Bax antagonist selected in saccharomyces 1; C21orf50; DBP-5; FLJ21099; FLJ33914; KIAA1019; NRE-binding protein; NREBP; Protein DBP-5; SON DNA binding protein; SON3
Type:
DNA binding protein
Mass (Da):
263846
Number AA:
2426
UniProt ID:
P18583
International Prot ID:
IPI00000192
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016607
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0003725
PhosphoSite+
KinaseNET
Biological Process:
GO:0006916
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T3
_
_
_
_
_
M
A
T
N
I
E
Q
I
F
R
Site 2
S11
N
I
E
Q
I
F
R
S
F
V
V
S
K
F
R
Site 3
S15
I
F
R
S
F
V
V
S
K
F
R
E
I
Q
Q
Site 4
S26
E
I
Q
Q
E
L
S
S
G
R
N
E
G
Q
L
Site 5
T37
E
G
Q
L
N
G
E
T
N
T
P
I
E
G
N
Site 6
T39
Q
L
N
G
E
T
N
T
P
I
E
G
N
Q
A
Site 7
S52
Q
A
G
D
A
A
A
S
A
R
S
L
P
N
E
Site 8
S55
D
A
A
A
S
A
R
S
L
P
N
E
E
I
V
Site 9
S70
Q
K
I
E
E
V
L
S
G
V
L
D
T
E
L
Site 10
S87
K
P
D
L
K
E
G
S
R
K
S
R
C
V
S
Site 11
S90
L
K
E
G
S
R
K
S
R
C
V
S
V
Q
T
Site 12
S94
S
R
K
S
R
C
V
S
V
Q
T
D
P
T
D
Site 13
T100
V
S
V
Q
T
D
P
T
D
E
I
P
T
K
K
Site 14
S108
D
E
I
P
T
K
K
S
K
K
H
K
K
H
K
Site 15
Y129
K
K
E
K
E
K
K
Y
K
R
Q
P
E
E
S
Site 16
S136
Y
K
R
Q
P
E
E
S
E
S
K
T
K
S
H
Site 17
S138
R
Q
P
E
E
S
E
S
K
T
K
S
H
D
D
Site 18
T140
P
E
E
S
E
S
K
T
K
S
H
D
D
G
N
Site 19
S142
E
S
E
S
K
T
K
S
H
D
D
G
N
I
D
Site 20
S152
D
G
N
I
D
L
E
S
D
S
F
L
K
F
D
Site 21
S154
N
I
D
L
E
S
D
S
F
L
K
F
D
S
E
Site 22
S160
D
S
F
L
K
F
D
S
E
P
S
A
V
A
L
Site 23
S177
P
T
R
A
F
G
P
S
E
T
N
E
S
P
A
Site 24
S182
G
P
S
E
T
N
E
S
P
A
V
V
L
E
P
Site 25
T204
S
E
P
H
I
L
E
T
L
K
P
A
T
K
T
Site 26
S220
E
L
S
V
V
S
T
S
V
I
S
E
Q
S
E
Site 27
S229
I
S
E
Q
S
E
Q
S
V
A
V
M
P
E
P
Site 28
S259
T
T
T
L
V
L
K
S
S
E
P
V
V
T
M
Site 29
T265
K
S
S
E
P
V
V
T
M
S
V
E
Y
Q
M
Site 30
S267
S
E
P
V
V
T
M
S
V
E
Y
Q
M
K
S
Site 31
Y270
V
V
T
M
S
V
E
Y
Q
M
K
S
V
L
K
Site 32
S274
S
V
E
Y
Q
M
K
S
V
L
K
S
V
E
S
Site 33
S278
Q
M
K
S
V
L
K
S
V
E
S
T
S
P
E
Site 34
S281
S
V
L
K
S
V
E
S
T
S
P
E
P
S
K
Site 35
T282
V
L
K
S
V
E
S
T
S
P
E
P
S
K
I
Site 36
S283
L
K
S
V
E
S
T
S
P
E
P
S
K
I
M
Site 37
S287
E
S
T
S
P
E
P
S
K
I
M
L
V
E
P
Site 38
S303
V
A
K
V
L
E
P
S
E
T
L
V
V
S
S
Site 39
T305
K
V
L
E
P
S
E
T
L
V
V
S
S
E
T
Site 40
S310
S
E
T
L
V
V
S
S
E
T
P
T
E
V
Y
Site 41
T312
T
L
V
V
S
S
E
T
P
T
E
V
Y
P
E
Site 42
T314
V
V
S
S
E
T
P
T
E
V
Y
P
E
P
S
Site 43
Y317
S
E
T
P
T
E
V
Y
P
E
P
S
T
S
T
Site 44
S321
T
E
V
Y
P
E
P
S
T
S
T
T
M
D
F
Site 45
S323
V
Y
P
E
P
S
T
S
T
T
M
D
F
P
E
Site 46
T324
Y
P
E
P
S
T
S
T
T
M
D
F
P
E
S
Site 47
T325
P
E
P
S
T
S
T
T
M
D
F
P
E
S
S
Site 48
S331
T
T
M
D
F
P
E
S
S
A
I
E
A
L
R
Site 49
S332
T
M
D
F
P
E
S
S
A
I
E
A
L
R
L
Site 50
S348
E
Q
P
V
D
V
P
S
E
I
A
D
S
S
M
Site 51
S353
V
P
S
E
I
A
D
S
S
M
T
R
P
Q
E
Site 52
S354
P
S
E
I
A
D
S
S
M
T
R
P
Q
E
L
Site 53
T367
E
L
P
E
L
P
K
T
T
A
L
E
L
Q
E
Site 54
S375
T
A
L
E
L
Q
E
S
S
V
A
S
A
M
E
Site 55
S379
L
Q
E
S
S
V
A
S
A
M
E
L
P
G
P
Site 56
T389
E
L
P
G
P
P
A
T
S
M
P
E
L
Q
G
Site 57
S390
L
P
G
P
P
A
T
S
M
P
E
L
Q
G
P
Site 58
T411
E
L
P
G
P
S
A
T
P
V
P
E
L
P
G
Site 59
S421
P
E
L
P
G
P
L
S
T
P
V
P
E
L
P
Site 60
T422
E
L
P
G
P
L
S
T
P
V
P
E
L
P
G
Site 61
T433
E
L
P
G
P
P
A
T
A
V
P
E
L
P
G
Site 62
T444
E
L
P
G
P
S
V
T
P
V
P
Q
L
S
Q
Site 63
S450
V
T
P
V
P
Q
L
S
Q
E
L
P
G
L
P
Site 64
S460
L
P
G
L
P
A
P
S
M
G
L
E
P
P
Q
Site 65
S473
P
Q
E
V
P
E
P
S
V
M
A
Q
E
L
P
Site 66
T509
E
L
T
E
Q
P
V
T
T
T
E
L
E
Q
P
Site 67
T521
E
Q
P
V
G
M
T
T
V
E
H
P
G
H
P
Site 68
T532
P
G
H
P
E
V
T
T
A
T
G
L
L
G
Q
Site 69
T567
L
P
G
Q
P
S
V
T
G
V
P
E
L
P
G
Site 70
S577
P
E
L
P
G
L
P
S
A
T
R
A
L
E
L
Site 71
S585
A
T
R
A
L
E
L
S
G
Q
P
V
A
T
G
Site 72
T668
T
S
E
L
S
T
M
T
V
S
Q
S
L
E
V
Site 73
S670
E
L
S
T
M
T
V
S
Q
S
L
E
V
P
S
Site 74
S672
S
T
M
T
V
S
Q
S
L
E
V
P
S
T
T
Site 75
S677
S
Q
S
L
E
V
P
S
T
T
A
L
E
S
Y
Site 76
T678
Q
S
L
E
V
P
S
T
T
A
L
E
S
Y
N
Site 77
T686
T
A
L
E
S
Y
N
T
V
A
Q
E
L
P
T
Site 78
S713
D
P
L
M
A
P
E
S
H
I
L
A
S
N
T
Site 79
S718
P
E
S
H
I
L
A
S
N
T
M
E
T
H
I
Site 80
S733
L
A
S
N
T
M
D
S
Q
M
L
A
S
N
T
Site 81
S753
L
A
S
N
T
M
D
S
Q
M
L
A
S
S
T
Site 82
S758
M
D
S
Q
M
L
A
S
S
T
M
D
S
Q
M
Site 83
S759
D
S
Q
M
L
A
S
S
T
M
D
S
Q
M
L
Site 84
S763
L
A
S
S
T
M
D
S
Q
M
L
A
T
S
S
Site 85
S769
D
S
Q
M
L
A
T
S
S
M
D
S
Q
M
L
Site 86
S770
S
Q
M
L
A
T
S
S
M
D
S
Q
M
L
A
Site 87
S773
L
A
T
S
S
M
D
S
Q
M
L
A
T
S
S
Site 88
S783
L
A
T
S
S
M
D
S
Q
M
L
A
T
S
T
Site 89
S789
D
S
Q
M
L
A
T
S
T
M
D
S
Q
M
L
Site 90
S793
L
A
T
S
T
M
D
S
Q
M
L
A
T
S
S
Site 91
S843
L
A
T
S
T
M
D
S
Q
M
L
A
T
S
T
Site 92
S863
L
A
T
S
S
M
D
S
Q
M
L
A
S
G
T
Site 93
S868
M
D
S
Q
M
L
A
S
G
T
M
D
S
Q
M
Site 94
S898
M
D
A
Q
M
L
A
S
S
T
Q
D
S
A
M
Site 95
S899
D
A
Q
M
L
A
S
S
T
Q
D
S
A
M
L
Site 96
S903
L
A
S
S
T
Q
D
S
A
M
L
G
S
K
S
Site 97
S908
Q
D
S
A
M
L
G
S
K
S
P
D
P
Y
R
Site 98
S910
S
A
M
L
G
S
K
S
P
D
P
Y
R
L
A
Site 99
Y914
G
S
K
S
P
D
P
Y
R
L
A
Q
D
P
Y
Site 100
Y921
Y
R
L
A
Q
D
P
Y
R
L
A
Q
D
P
Y
Site 101
Y928
Y
R
L
A
Q
D
P
Y
R
L
G
H
D
P
Y
Site 102
Y935
Y
R
L
G
H
D
P
Y
R
L
G
H
D
A
Y
Site 103
Y942
Y
R
L
G
H
D
A
Y
R
L
G
Q
D
P
Y
Site 104
Y949
Y
R
L
G
Q
D
P
Y
R
L
G
H
D
P
Y
Site 105
Y956
Y
R
L
G
H
D
P
Y
R
L
T
P
D
P
Y
Site 106
T959
G
H
D
P
Y
R
L
T
P
D
P
Y
R
M
S
Site 107
Y963
Y
R
L
T
P
D
P
Y
R
M
S
P
R
P
Y
Site 108
S966
T
P
D
P
Y
R
M
S
P
R
P
Y
R
I
A
Site 109
Y970
Y
R
M
S
P
R
P
Y
R
I
A
P
R
S
Y
Site 110
S976
P
Y
R
I
A
P
R
S
Y
R
I
A
P
R
P
Site 111
Y977
Y
R
I
A
P
R
S
Y
R
I
A
P
R
P
Y
Site 112
S995
P
R
P
L
M
L
A
S
R
R
S
M
M
M
S
Site 113
S998
L
M
L
A
S
R
R
S
M
M
M
S
Y
A
A
Site 114
S1002
S
R
R
S
M
M
M
S
Y
A
A
E
R
S
M
Site 115
Y1003
R
R
S
M
M
M
S
Y
A
A
E
R
S
M
M
Site 116
S1008
M
S
Y
A
A
E
R
S
M
M
S
S
Y
E
R
Site 117
S1012
A
E
R
S
M
M
S
S
Y
E
R
S
M
M
S
Site 118
Y1013
E
R
S
M
M
S
S
Y
E
R
S
M
M
S
Y
Site 119
S1016
M
M
S
S
Y
E
R
S
M
M
S
Y
E
R
S
Site 120
S1019
S
Y
E
R
S
M
M
S
Y
E
R
S
M
M
S
Site 121
Y1020
Y
E
R
S
M
M
S
Y
E
R
S
M
M
S
P
Site 122
S1023
S
M
M
S
Y
E
R
S
M
M
S
P
M
A
E
Site 123
S1026
S
Y
E
R
S
M
M
S
P
M
A
E
R
S
M
Site 124
S1032
M
S
P
M
A
E
R
S
M
M
S
A
Y
E
R
Site 125
S1035
M
A
E
R
S
M
M
S
A
Y
E
R
S
M
M
Site 126
Y1037
E
R
S
M
M
S
A
Y
E
R
S
M
M
S
A
Site 127
S1043
A
Y
E
R
S
M
M
S
A
Y
E
R
S
M
M
Site 128
Y1045
E
R
S
M
M
S
A
Y
E
R
S
M
M
S
P
Site 129
S1051
A
Y
E
R
S
M
M
S
P
M
A
E
R
S
M
Site 130
S1076
A
Y
E
R
S
M
M
S
P
M
A
D
R
S
M
Site 131
S1082
M
S
P
M
A
D
R
S
M
M
S
M
G
A
D
Site 132
S1091
M
S
M
G
A
D
R
S
M
M
S
S
Y
S
A
Site 133
S1095
A
D
R
S
M
M
S
S
Y
S
A
A
D
R
S
Site 134
Y1096
D
R
S
M
M
S
S
Y
S
A
A
D
R
S
M
Site 135
S1097
R
S
M
M
S
S
Y
S
A
A
D
R
S
M
M
Site 136
S1102
S
Y
S
A
A
D
R
S
M
M
S
S
Y
S
A
Site 137
S1113
S
Y
S
A
A
D
R
S
M
M
S
S
Y
T
A
Site 138
S1116
A
A
D
R
S
M
M
S
S
Y
T
A
D
R
S
Site 139
S1117
A
D
R
S
M
M
S
S
Y
T
A
D
R
S
M
Site 140
T1119
R
S
M
M
S
S
Y
T
A
D
R
S
M
M
S
Site 141
S1123
S
S
Y
T
A
D
R
S
M
M
S
M
A
A
D
Site 142
S1131
M
M
S
M
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R
S
P
K
R
L
T
D
L
D
K
A
Q
L
Site 295
T2088
L
K
P
A
P
P
P
T
I
E
E
K
V
A
K
Site 296
T2101
A
K
K
S
G
G
A
T
I
E
E
L
T
E
K
Site 297
T2106
G
A
T
I
E
E
L
T
E
K
C
K
Q
I
A
Site 298
S2129
I
V
N
K
P
H
V
S
D
E
E
E
E
E
P
Site 299
Y2139
E
E
E
E
P
P
F
Y
H
H
P
F
K
L
S
Site 300
T2163
N
I
A
A
A
K
P
T
P
P
K
S
Q
V
T
Site 301
S2167
A
K
P
T
P
P
K
S
Q
V
T
L
T
K
E
Site 302
T2172
P
K
S
Q
V
T
L
T
K
E
F
P
V
S
S
Site 303
S2178
L
T
K
E
F
P
V
S
S
G
S
Q
H
R
K
Site 304
S2179
T
K
E
F
P
V
S
S
G
S
Q
H
R
K
K
Site 305
S2181
E
F
P
V
S
S
G
S
Q
H
R
K
K
E
A
Site 306
S2190
H
R
K
K
E
A
D
S
V
Y
G
E
W
V
P
Site 307
Y2192
K
K
E
A
D
S
V
Y
G
E
W
V
P
V
E
Site 308
S2214
D
D
D
N
V
F
S
S
N
L
P
S
E
P
V
Site 309
S2218
V
F
S
S
N
L
P
S
E
P
V
D
I
S
T
Site 310
S2224
P
S
E
P
V
D
I
S
T
A
M
S
E
R
A
Site 311
T2225
S
E
P
V
D
I
S
T
A
M
S
E
R
A
L
Site 312
S2228
V
D
I
S
T
A
M
S
E
R
A
L
A
Q
K
Site 313
S2238
A
L
A
Q
K
R
L
S
E
N
A
F
D
L
E
Site 314
S2265
D
A
W
A
Q
L
N
S
I
P
G
Q
F
T
G
Site 315
T2274
P
G
Q
F
T
G
S
T
G
V
Q
V
L
T
Q
Site 316
S2357
G
E
R
A
Q
K
R
S
G
N
F
S
A
A
M
Site 317
S2361
Q
K
R
S
G
N
F
S
A
A
M
K
D
L
S
Site 318
S2368
S
A
A
M
K
D
L
S
G
K
H
P
V
S
A
Site 319
S2396
E
F
L
L
V
H
D
S
G
P
D
H
R
K
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation