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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RCC1
Full Name:
Regulator of chromosome condensation
Alias:
Cell cycle regulatory protein; CHC1; regulator of chromosome condensation 1
Type:
Guanine nucleotide exchange factor for G protein
Mass (Da):
44969
Number AA:
421
UniProt ID:
P18754
International Prot ID:
IPI00747309
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000794
GO:0005737
GO:0000790
Uniprot
OncoNet
Molecular Function:
GO:0005087
GO:0003682
GO:0042393
PhosphoSite+
KinaseNET
Biological Process:
GO:0000082
GO:0051301
GO:0007067
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S2
_
_
_
_
_
_
M
S
P
K
R
I
A
K
R
Site 2
S11
K
R
I
A
K
R
R
S
P
P
A
D
A
I
P
Site 3
S20
P
A
D
A
I
P
K
S
K
K
V
K
V
S
H
Site 4
S26
K
S
K
K
V
K
V
S
H
R
S
H
S
T
E
Site 5
S29
K
V
K
V
S
H
R
S
H
S
T
E
P
G
L
Site 6
S31
K
V
S
H
R
S
H
S
T
E
P
G
L
V
L
Site 7
T32
V
S
H
R
S
H
S
T
E
P
G
L
V
L
T
Site 8
T39
T
E
P
G
L
V
L
T
L
G
Q
G
D
V
G
Site 9
T79
A
E
A
G
G
M
H
T
V
C
L
S
K
S
G
Site 10
S83
G
M
H
T
V
C
L
S
K
S
G
Q
V
Y
S
Site 11
S85
H
T
V
C
L
S
K
S
G
Q
V
Y
S
F
G
Site 12
Y89
L
S
K
S
G
Q
V
Y
S
F
G
C
N
D
E
Site 13
S90
S
K
S
G
Q
V
Y
S
F
G
C
N
D
E
G
Site 14
T103
E
G
A
L
G
R
D
T
S
V
E
G
S
E
M
Site 15
S104
G
A
L
G
R
D
T
S
V
E
G
S
E
M
V
Site 16
S108
R
D
T
S
V
E
G
S
E
M
V
P
G
K
V
Site 17
S129
V
Q
V
S
A
G
D
S
H
T
A
A
L
T
D
Site 18
T131
V
S
A
G
D
S
H
T
A
A
L
T
D
D
G
Site 19
S145
G
R
V
F
L
W
G
S
F
R
D
N
N
G
V
Site 20
Y194
L
T
A
D
G
D
L
Y
T
L
G
C
G
E
Q
Site 21
T195
T
A
D
G
D
L
Y
T
L
G
C
G
E
Q
G
Site 22
S233
P
K
C
V
M
L
K
S
R
G
S
R
G
H
V
Site 23
S236
V
M
L
K
S
R
G
S
R
G
H
V
R
F
Q
Site 24
Y262
I
S
H
E
G
H
V
Y
G
F
G
L
S
N
Y
Site 25
Y269
Y
G
F
G
L
S
N
Y
H
Q
L
G
T
P
G
Site 26
T274
S
N
Y
H
Q
L
G
T
P
G
T
E
S
C
F
Site 27
T277
H
Q
L
G
T
P
G
T
E
S
C
F
I
P
Q
Site 28
S288
F
I
P
Q
N
L
T
S
F
K
N
S
T
K
S
Site 29
S292
N
L
T
S
F
K
N
S
T
K
S
W
V
G
F
Site 30
S295
S
F
K
N
S
T
K
S
W
V
G
F
S
G
G
Site 31
T306
F
S
G
G
Q
H
H
T
V
C
M
D
S
E
G
Site 32
S311
H
H
T
V
C
M
D
S
E
G
K
A
Y
S
L
Site 33
Y316
M
D
S
E
G
K
A
Y
S
L
G
R
A
E
Y
Site 34
S317
D
S
E
G
K
A
Y
S
L
G
R
A
E
Y
G
Site 35
Y323
Y
S
L
G
R
A
E
Y
G
R
L
G
L
G
E
Site 36
S336
G
E
G
A
E
E
K
S
I
P
T
L
I
S
R
Site 37
Y375
A
W
G
M
G
T
N
Y
Q
L
G
T
G
Q
D
Site 38
S387
G
Q
D
E
D
A
W
S
P
V
E
M
M
G
K
Site 39
S403
L
E
N
R
V
V
L
S
V
S
S
G
G
Q
H
Site 40
S405
N
R
V
V
L
S
V
S
S
G
G
Q
H
T
V
Site 41
S406
R
V
V
L
S
V
S
S
G
G
Q
H
T
V
L
Site 42
T411
V
S
S
G
G
Q
H
T
V
L
L
V
K
D
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation