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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TRIM21
Full Name:
E3 ubiquitin-protein ligase TRIM21
Alias:
52 kDa ribonucleoprotein autoantigen Ro/SS-A; 52 kDa Ro; RING finger protein 81; RNF81; RO52
Type:
Uncharacterized protein
Mass (Da):
54170
Number AA:
475
UniProt ID:
P19474
International Prot ID:
IPI00018971
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
GO:0030529
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0003723
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0070206
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S28
D
P
F
V
E
P
V
S
I
E
C
G
H
S
F
Site 2
S41
S
F
C
Q
E
C
I
S
Q
V
G
K
G
G
G
Site 3
S49
Q
V
G
K
G
G
G
S
V
C
P
V
C
R
Q
Site 4
T87
S
Q
E
A
R
E
G
T
Q
G
E
R
C
A
V
Site 5
T170
K
R
A
D
W
K
K
T
V
E
T
Q
K
S
R
Site 6
S176
K
T
V
E
T
Q
K
S
R
I
H
A
E
F
V
Site 7
S230
Q
A
L
Q
E
L
I
S
E
L
D
R
R
C
H
Site 8
S238
E
L
D
R
R
C
H
S
S
A
L
E
L
L
Q
Site 9
S239
L
D
R
R
C
H
S
S
A
L
E
L
L
Q
E
Site 10
S254
V
I
I
V
L
E
R
S
E
S
W
N
L
K
D
Site 11
S256
I
V
L
E
R
S
E
S
W
N
L
K
D
L
D
Site 12
S266
L
K
D
L
D
I
T
S
P
E
L
R
S
V
C
Site 13
T290
R
T
C
A
V
H
I
T
L
D
P
D
T
A
N
Site 14
S303
A
N
P
W
L
I
L
S
E
D
R
R
Q
V
R
Site 15
T314
R
Q
V
R
L
G
D
T
Q
Q
S
I
P
G
N
Site 16
S317
R
L
G
D
T
Q
Q
S
I
P
G
N
E
E
R
Site 17
S327
G
N
E
E
R
F
D
S
Y
P
M
V
L
G
A
Site 18
Y328
N
E
E
R
F
D
S
Y
P
M
V
L
G
A
Q
Site 19
Y343
H
F
H
S
G
K
H
Y
W
E
V
D
V
T
G
Site 20
S362
D
L
G
V
C
R
D
S
V
R
R
K
G
H
F
Site 21
S372
R
K
G
H
F
L
L
S
S
K
S
G
F
W
T
Site 22
S373
K
G
H
F
L
L
S
S
K
S
G
F
W
T
I
Site 23
Y388
W
L
W
N
K
Q
K
Y
E
A
G
T
Y
P
Q
Site 24
Y393
Q
K
Y
E
A
G
T
Y
P
Q
T
P
L
H
L
Site 25
T396
E
A
G
T
Y
P
Q
T
P
L
H
L
Q
V
P
Site 26
S428
Y
N
I
T
D
H
G
S
L
I
Y
S
F
S
E
Site 27
S447
G
P
L
R
P
F
F
S
P
G
F
N
D
G
G
Site 28
S469
L
C
P
L
N
I
G
S
Q
G
S
T
D
Y
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation