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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TFEB
Full Name:
Transcription factor EB
Alias:
AlphaTFEB; TCFEB
Type:
Nucleus, Transcription protein complex protein
Mass (Da):
52865
Number AA:
476
UniProt ID:
P19484
International Prot ID:
IPI00465427
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0010843
GO:0003700
PhosphoSite+
KinaseNET
Biological Process:
GO:0001892
GO:0006959
GO:0010552
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T50
Q
Q
L
G
G
P
P
T
P
A
I
N
T
P
V
Site 2
T55
P
P
T
P
A
I
N
T
P
V
H
F
Q
S
P
Site 3
S61
N
T
P
V
H
F
Q
S
P
P
P
V
P
G
E
Site 4
S74
G
E
V
L
K
V
Q
S
Y
L
E
N
P
T
S
Site 5
Y75
E
V
L
K
V
Q
S
Y
L
E
N
P
T
S
Y
Site 6
S81
S
Y
L
E
N
P
T
S
Y
H
L
Q
Q
S
Q
Site 7
S87
T
S
Y
H
L
Q
Q
S
Q
H
Q
K
V
R
E
Site 8
Y95
Q
H
Q
K
V
R
E
Y
L
S
E
T
Y
G
N
Site 9
S97
Q
K
V
R
E
Y
L
S
E
T
Y
G
N
K
F
Site 10
Y100
R
E
Y
L
S
E
T
Y
G
N
K
F
A
A
H
Site 11
S109
N
K
F
A
A
H
I
S
P
A
Q
G
S
P
K
Site 12
S114
H
I
S
P
A
Q
G
S
P
K
P
P
P
A
A
Site 13
S122
P
K
P
P
P
A
A
S
P
G
V
R
A
G
H
Site 14
S132
V
R
A
G
H
V
L
S
S
S
A
G
N
S
A
Site 15
S133
R
A
G
H
V
L
S
S
S
A
G
N
S
A
P
Site 16
S134
A
G
H
V
L
S
S
S
A
G
N
S
A
P
N
Site 17
S138
L
S
S
S
A
G
N
S
A
P
N
S
P
M
A
Site 18
S142
A
G
N
S
A
P
N
S
P
M
A
M
L
H
I
Site 19
Y173
R
L
D
D
V
L
G
Y
I
N
P
E
M
Q
M
Site 20
T183
P
E
M
Q
M
P
N
T
L
P
L
S
S
S
H
Site 21
S187
M
P
N
T
L
P
L
S
S
S
H
L
N
V
Y
Site 22
S189
N
T
L
P
L
S
S
S
H
L
N
V
Y
S
S
Site 23
Y194
S
S
S
H
L
N
V
Y
S
S
D
P
Q
V
T
Site 24
S196
S
H
L
N
V
Y
S
S
D
P
Q
V
T
A
S
Site 25
S211
L
V
G
V
T
S
S
S
C
P
A
D
L
T
Q
Site 26
T217
S
S
C
P
A
D
L
T
Q
K
R
E
L
T
D
Site 27
T223
L
T
Q
K
R
E
L
T
D
A
E
S
R
A
L
Site 28
S227
R
E
L
T
D
A
E
S
R
A
L
A
K
E
R
Site 29
T276
D
V
R
W
N
K
G
T
I
L
K
A
S
V
D
Site 30
S281
K
G
T
I
L
K
A
S
V
D
Y
I
R
R
M
Site 31
Y284
I
L
K
A
S
V
D
Y
I
R
R
M
Q
K
D
Site 32
S295
M
Q
K
D
L
Q
K
S
R
E
L
E
N
H
S
Site 33
S302
S
R
E
L
E
N
H
S
R
R
L
E
M
T
N
Site 34
T308
H
S
R
R
L
E
M
T
N
K
Q
L
W
L
R
Site 35
T330
A
R
V
H
G
L
P
T
T
S
P
S
G
M
N
Site 36
T331
R
V
H
G
L
P
T
T
S
P
S
G
M
N
M
Site 37
S332
V
H
G
L
P
T
T
S
P
S
G
M
N
M
A
Site 38
S334
G
L
P
T
T
S
P
S
G
M
N
M
A
E
L
Site 39
T385
Q
A
P
L
P
L
P
T
Q
P
P
S
P
F
H
Site 40
S389
P
L
P
T
Q
P
P
S
P
F
H
H
L
D
F
Site 41
S397
P
F
H
H
L
D
F
S
H
S
L
S
F
G
G
Site 42
S399
H
H
L
D
F
S
H
S
L
S
F
G
G
R
E
Site 43
S401
L
D
F
S
H
S
L
S
F
G
G
R
E
D
E
Site 44
Y413
E
D
E
G
P
P
G
Y
P
E
P
L
A
P
G
Site 45
S423
G
L
P
T
T
S
P
S
G
M
N
M
A
E
L
Site 46
S427
G
H
G
S
P
F
P
S
L
S
K
K
D
L
D
Site 47
S429
G
S
P
F
P
S
L
S
K
K
D
L
D
L
M
Site 48
S441
D
L
M
L
L
D
D
S
L
L
P
L
A
S
D
Site 49
S452
L
A
S
D
P
L
L
S
T
M
S
P
E
A
S
Site 50
T453
A
S
D
P
L
L
S
T
M
S
P
E
A
S
K
Site 51
S455
D
P
L
L
S
T
M
S
P
E
A
S
K
A
S
Site 52
S459
S
T
M
S
P
E
A
S
K
A
S
S
R
R
S
Site 53
S462
S
P
E
A
S
K
A
S
S
R
R
S
S
F
S
Site 54
S463
P
E
A
S
K
A
S
S
R
R
S
S
F
S
M
Site 55
S466
S
K
A
S
S
R
R
S
S
F
S
M
E
E
G
Site 56
S467
K
A
S
S
R
R
S
S
F
S
M
E
E
G
D
Site 57
S469
S
S
R
R
S
S
F
S
M
E
E
G
D
V
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation