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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TFE3
Full Name:
Transcription factor E3
Alias:
BHLHe33; TFEA; Transcription factor binding to IGHM enhancer 3; Transcription factor E family, member A
Type:
Mass (Da):
61521
Number AA:
575
UniProt ID:
P19532
International Prot ID:
IPI00019490
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0043226
GO:0043227
Uniprot
OncoNet
Molecular Function:
GO:0003676
GO:0003677
GO:0003700
PhosphoSite+
KinaseNET
Biological Process:
GO:0006139
GO:0006350
GO:0006355
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S34
E
E
R
R
P
A
D
S
A
Q
L
L
S
L
N
Site 2
S63
E
N
V
L
D
P
D
S
F
Y
E
L
K
S
Q
Site 3
Y65
V
L
D
P
D
S
F
Y
E
L
K
S
Q
P
L
Site 4
S69
D
S
F
Y
E
L
K
S
Q
P
L
P
L
R
S
Site 5
S76
S
Q
P
L
P
L
R
S
S
L
P
I
S
L
Q
Site 6
S77
Q
P
L
P
L
R
S
S
L
P
I
S
L
Q
A
Site 7
S93
P
A
T
P
A
T
L
S
A
S
S
S
A
G
G
Site 8
S95
T
P
A
T
L
S
A
S
S
S
A
G
G
S
R
Site 9
S97
A
T
L
S
A
S
S
S
A
G
G
S
R
T
P
Site 10
S101
A
S
S
S
A
G
G
S
R
T
P
A
M
S
S
Site 11
T103
S
S
A
G
G
S
R
T
P
A
M
S
S
S
S
Site 12
S107
G
S
R
T
P
A
M
S
S
S
S
S
S
R
V
Site 13
S108
S
R
T
P
A
M
S
S
S
S
S
S
R
V
L
Site 14
S109
R
T
P
A
M
S
S
S
S
S
S
R
V
L
L
Site 15
S110
T
P
A
M
S
S
S
S
S
S
R
V
L
L
R
Site 16
S111
P
A
M
S
S
S
S
S
S
R
V
L
L
R
Q
Site 17
S112
A
M
S
S
S
S
S
S
R
V
L
L
R
Q
Q
Site 18
T163
G
V
S
A
G
G
H
T
L
S
R
P
P
P
A
Site 19
S165
S
A
G
G
H
T
L
S
R
P
P
P
A
Q
V
Site 20
Y202
R
R
Q
Q
V
K
Q
Y
L
S
T
T
L
G
P
Site 21
S204
Q
Q
V
K
Q
Y
L
S
T
T
L
G
P
K
L
Site 22
T206
V
K
Q
Y
L
S
T
T
L
G
P
K
L
A
S
Site 23
S213
T
L
G
P
K
L
A
S
Q
A
L
T
P
P
P
Site 24
T217
K
L
A
S
Q
A
L
T
P
P
P
G
P
A
S
Site 25
S224
T
P
P
P
G
P
A
S
A
Q
P
L
P
A
P
Site 26
T236
P
A
P
E
A
A
H
T
T
G
P
T
G
S
A
Site 27
S242
H
T
T
G
P
T
G
S
A
P
N
S
P
M
A
Site 28
S246
P
T
G
S
A
P
N
S
P
M
A
L
L
T
I
Site 29
T252
N
S
P
M
A
L
L
T
I
G
S
S
S
E
K
Site 30
S255
M
A
L
L
T
I
G
S
S
S
E
K
E
I
D
Site 31
S256
A
L
L
T
I
G
S
S
S
E
K
E
I
D
D
Site 32
S257
L
L
T
I
G
S
S
S
E
K
E
I
D
D
V
Site 33
S270
D
V
I
D
E
I
I
S
L
E
S
S
Y
N
D
Site 34
S274
E
I
I
S
L
E
S
S
Y
N
D
E
M
L
S
Site 35
S281
S
Y
N
D
E
M
L
S
Y
L
P
G
G
T
T
Site 36
Y282
Y
N
D
E
M
L
S
Y
L
P
G
G
T
T
G
Site 37
T288
S
Y
L
P
G
G
T
T
G
L
Q
L
P
S
T
Site 38
S294
T
T
G
L
Q
L
P
S
T
L
P
V
S
G
N
Site 39
Y306
S
G
N
L
L
D
V
Y
S
S
Q
G
V
A
T
Site 40
S307
G
N
L
L
D
V
Y
S
S
Q
G
V
A
T
P
Site 41
T313
Y
S
S
Q
G
V
A
T
P
A
I
T
V
S
N
Site 42
S321
P
A
I
T
V
S
N
S
C
P
A
E
L
P
N
Site 43
S334
P
N
I
K
R
E
I
S
E
T
E
A
K
A
L
Site 44
T336
I
K
R
E
I
S
E
T
E
A
K
A
L
L
K
Site 45
T371
D
R
I
K
E
L
G
T
L
I
P
K
S
S
D
Site 46
S376
L
G
T
L
I
P
K
S
S
D
P
E
M
R
W
Site 47
S377
G
T
L
I
P
K
S
S
D
P
E
M
R
W
N
Site 48
T387
E
M
R
W
N
K
G
T
I
L
K
A
S
V
D
Site 49
S392
K
G
T
I
L
K
A
S
V
D
Y
I
R
K
L
Site 50
Y395
I
L
K
A
S
V
D
Y
I
R
K
L
Q
K
E
Site 51
S406
L
Q
K
E
Q
Q
R
S
K
D
L
E
S
R
Q
Site 52
S411
Q
R
S
K
D
L
E
S
R
Q
R
S
L
E
Q
Site 53
S415
D
L
E
S
R
Q
R
S
L
E
Q
A
N
R
S
Site 54
S456
S
L
A
T
T
S
A
S
D
S
L
K
P
E
Q
Site 55
S458
A
T
T
S
A
S
D
S
L
K
P
E
Q
L
D
Site 56
T476
E
G
R
P
G
A
A
T
F
H
V
G
G
G
P
Site 57
S497
Q
Q
P
P
A
P
P
S
D
A
L
L
D
L
H
Site 58
S542
G
L
S
G
G
A
L
S
P
L
R
A
A
S
D
Site 59
S548
L
S
P
L
R
A
A
S
D
P
L
L
S
S
V
Site 60
S554
A
S
D
P
L
L
S
S
V
S
P
A
V
S
K
Site 61
S556
D
P
L
L
S
S
V
S
P
A
V
S
K
A
S
Site 62
S560
S
S
V
S
P
A
V
S
K
A
S
S
R
R
S
Site 63
S563
S
P
A
V
S
K
A
S
S
R
R
S
S
F
S
Site 64
S564
P
A
V
S
K
A
S
S
R
R
S
S
F
S
M
Site 65
S567
S
K
A
S
S
R
R
S
S
F
S
M
E
E
E
Site 66
S568
K
A
S
S
R
R
S
S
F
S
M
E
E
E
S
Site 67
S570
S
S
R
R
S
S
F
S
M
E
E
E
S
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation