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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CHRM3
Full Name:
Muscarinic acetylcholine receptor M3
Alias:
ACM3; Cholinergic receptor, muscarinic 3
Type:
Receptor - G protein-coupled; plasma membrane, integral plasma membrane, postsynaptic membrane, synapse, basolateral plasma membrane, cell junction protein
Mass (Da):
66128
Number AA:
590
UniProt ID:
P20309
International Prot ID:
IPI00023456
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030054
GO:0005887
GO:0045211
Uniprot
OncoNet
Molecular Function:
GO:0004981
GO:0004435
PhosphoSite+
KinaseNET
Biological Process:
GO:0008283
GO:0007399
GO:0006464
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
T
L
H
N
N
S
T
T
S
P
L
F
P
Site 2
T8
M
T
L
H
N
N
S
T
T
S
P
L
F
P
N
Site 3
S10
L
H
N
N
S
T
T
S
P
L
F
P
N
I
S
Site 4
S17
S
P
L
F
P
N
I
S
S
S
W
I
H
S
P
Site 5
S18
P
L
F
P
N
I
S
S
S
W
I
H
S
P
S
Site 6
S19
L
F
P
N
I
S
S
S
W
I
H
S
P
S
D
Site 7
S23
I
S
S
S
W
I
H
S
P
S
D
A
G
L
P
Site 8
S25
S
S
W
I
H
S
P
S
D
A
G
L
P
P
G
Site 9
T33
D
A
G
L
P
P
G
T
V
T
H
F
G
S
Y
Site 10
T35
G
L
P
P
G
T
V
T
H
F
G
S
Y
N
V
Site 11
S39
G
T
V
T
H
F
G
S
Y
N
V
S
R
A
A
Site 12
S43
H
F
G
S
Y
N
V
S
R
A
A
G
N
F
S
Site 13
S50
S
R
A
A
G
N
F
S
S
P
D
G
T
T
D
Site 14
S51
R
A
A
G
N
F
S
S
P
D
G
T
T
D
D
Site 15
T55
N
F
S
S
P
D
G
T
T
D
D
P
L
G
G
Site 16
T56
F
S
S
P
D
G
T
T
D
D
P
L
G
G
H
Site 17
T101
K
V
N
K
Q
L
K
T
V
N
N
Y
F
L
L
Site 18
S169
I
S
F
D
R
Y
F
S
I
T
R
P
L
T
Y
Site 19
T171
F
D
R
Y
F
S
I
T
R
P
L
T
Y
R
A
Site 20
T175
F
S
I
T
R
P
L
T
Y
R
A
K
R
T
T
Site 21
T182
T
Y
R
A
K
R
T
T
K
R
A
G
V
M
I
Site 22
T215
Q
Y
F
V
G
K
R
T
V
P
P
G
E
C
F
Site 23
Y255
T
I
L
Y
W
R
I
Y
K
E
T
E
K
R
T
Site 24
T258
Y
W
R
I
Y
K
E
T
E
K
R
T
K
E
L
Site 25
T273
A
G
L
Q
A
S
G
T
E
A
E
T
E
N
F
Site 26
T284
T
E
N
F
V
H
P
T
G
S
S
R
S
C
S
Site 27
S286
N
F
V
H
P
T
G
S
S
R
S
C
S
S
Y
Site 28
S287
F
V
H
P
T
G
S
S
R
S
C
S
S
Y
E
Site 29
S289
H
P
T
G
S
S
R
S
C
S
S
Y
E
L
Q
Site 30
S291
T
G
S
S
R
S
C
S
S
Y
E
L
Q
Q
Q
Site 31
S292
G
S
S
R
S
C
S
S
Y
E
L
Q
Q
Q
S
Site 32
Y293
S
S
R
S
C
S
S
Y
E
L
Q
Q
Q
S
M
Site 33
S299
S
Y
E
L
Q
Q
Q
S
M
K
R
S
N
R
R
Site 34
S303
Q
Q
Q
S
M
K
R
S
N
R
R
K
Y
G
R
Site 35
S323
T
T
K
S
W
K
P
S
S
E
Q
M
D
Q
D
Site 36
S324
T
K
S
W
K
P
S
S
E
Q
M
D
Q
D
H
Site 37
S332
E
Q
M
D
Q
D
H
S
S
S
D
S
W
N
N
Site 38
S333
Q
M
D
Q
D
H
S
S
S
D
S
W
N
N
N
Site 39
S334
M
D
Q
D
H
S
S
S
D
S
W
N
N
N
D
Site 40
S336
Q
D
H
S
S
S
D
S
W
N
N
N
D
A
A
Site 41
S345
N
N
N
D
A
A
A
S
L
E
N
S
A
S
S
Site 42
S349
A
A
A
S
L
E
N
S
A
S
S
D
E
E
D
Site 43
S351
A
S
L
E
N
S
A
S
S
D
E
E
D
I
G
Site 44
S359
S
D
E
E
D
I
G
S
E
T
R
A
I
Y
S
Site 45
Y365
G
S
E
T
R
A
I
Y
S
I
V
L
K
L
P
Site 46
S366
S
E
T
R
A
I
Y
S
I
V
L
K
L
P
G
Site 47
T376
L
K
L
P
G
H
S
T
I
L
N
S
T
K
L
Site 48
S380
G
H
S
T
I
L
N
S
T
K
L
P
S
S
D
Site 49
T381
H
S
T
I
L
N
S
T
K
L
P
S
S
D
N
Site 50
S385
L
N
S
T
K
L
P
S
S
D
N
L
Q
V
P
Site 51
S386
N
S
T
K
L
P
S
S
D
N
L
Q
V
P
E
Site 52
S413
D
K
L
Q
A
Q
K
S
V
D
D
G
G
S
F
Site 53
S419
K
S
V
D
D
G
G
S
F
P
K
S
F
S
K
Site 54
S423
D
G
G
S
F
P
K
S
F
S
K
L
P
I
Q
Site 55
S425
G
S
F
P
K
S
F
S
K
L
P
I
Q
L
E
Site 56
T437
Q
L
E
S
A
V
D
T
A
K
T
S
D
V
N
Site 57
T440
S
A
V
D
T
A
K
T
S
D
V
N
S
S
V
Site 58
S441
A
V
D
T
A
K
T
S
D
V
N
S
S
V
G
Site 59
S445
A
K
T
S
D
V
N
S
S
V
G
K
S
T
A
Site 60
S446
K
T
S
D
V
N
S
S
V
G
K
S
T
A
T
Site 61
T451
N
S
S
V
G
K
S
T
A
T
L
P
L
S
F
Site 62
T453
S
V
G
K
S
T
A
T
L
P
L
S
F
K
E
Site 63
S457
S
T
A
T
L
P
L
S
F
K
E
A
T
L
A
Site 64
T471
A
K
R
F
A
L
K
T
R
S
Q
I
T
K
R
Site 65
S473
R
F
A
L
K
T
R
S
Q
I
T
K
R
K
R
Site 66
T476
L
K
T
R
S
Q
I
T
K
R
K
R
M
S
L
Site 67
S482
I
T
K
R
K
R
M
S
L
V
K
E
K
K
A
Site 68
Y530
K
T
F
W
N
L
G
Y
W
L
C
Y
I
N
S
Site 69
Y534
N
L
G
Y
W
L
C
Y
I
N
S
T
V
N
P
Site 70
Y544
S
T
V
N
P
V
C
Y
A
L
C
N
K
T
F
Site 71
Y573
K
K
R
R
K
Q
Q
Y
Q
Q
R
Q
S
V
I
Site 72
S578
Q
Q
Y
Q
Q
R
Q
S
V
I
F
H
K
R
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation