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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NR1D1
Full Name:
Nuclear receptor subfamily 1 group D member 1
Alias:
Rev-erbA-alpha;V-erbA-related protein 1
Type:
Mass (Da):
66805
Number AA:
614
UniProt ID:
P20393
International Prot ID:
IPI00023603
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0043565
GO:0003707
GO:0003714
PhosphoSite+
KinaseNET
Biological Process:
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T10
T
L
D
S
N
N
N
T
G
G
V
I
T
Y
I
Site 2
T15
N
N
T
G
G
V
I
T
Y
I
G
S
S
G
S
Site 3
Y16
N
T
G
G
V
I
T
Y
I
G
S
S
G
S
S
Site 4
S19
G
V
I
T
Y
I
G
S
S
G
S
S
P
S
R
Site 5
S20
V
I
T
Y
I
G
S
S
G
S
S
P
S
R
T
Site 6
S22
T
Y
I
G
S
S
G
S
S
P
S
R
T
S
P
Site 7
S23
Y
I
G
S
S
G
S
S
P
S
R
T
S
P
E
Site 8
S25
G
S
S
G
S
S
P
S
R
T
S
P
E
S
L
Site 9
T27
S
G
S
S
P
S
R
T
S
P
E
S
L
Y
S
Site 10
S28
G
S
S
P
S
R
T
S
P
E
S
L
Y
S
D
Site 11
S31
P
S
R
T
S
P
E
S
L
Y
S
D
N
S
N
Site 12
Y33
R
T
S
P
E
S
L
Y
S
D
N
S
N
G
S
Site 13
S34
T
S
P
E
S
L
Y
S
D
N
S
N
G
S
F
Site 14
S37
E
S
L
Y
S
D
N
S
N
G
S
F
Q
S
L
Site 15
S40
Y
S
D
N
S
N
G
S
F
Q
S
L
T
Q
G
Site 16
S43
N
S
N
G
S
F
Q
S
L
T
Q
G
C
P
T
Site 17
T45
N
G
S
F
Q
S
L
T
Q
G
C
P
T
Y
F
Site 18
T50
S
L
T
Q
G
C
P
T
Y
F
P
P
S
P
T
Site 19
Y51
L
T
Q
G
C
P
T
Y
F
P
P
S
P
T
G
Site 20
S55
C
P
T
Y
F
P
P
S
P
T
G
S
L
T
Q
Site 21
S59
F
P
P
S
P
T
G
S
L
T
Q
D
P
A
R
Site 22
T61
P
S
P
T
G
S
L
T
Q
D
P
A
R
S
F
Site 23
S67
L
T
Q
D
P
A
R
S
F
G
S
I
P
P
S
Site 24
S70
D
P
A
R
S
F
G
S
I
P
P
S
L
S
D
Site 25
S74
S
F
G
S
I
P
P
S
L
S
D
D
G
S
P
Site 26
S76
G
S
I
P
P
S
L
S
D
D
G
S
P
S
S
Site 27
S80
P
S
L
S
D
D
G
S
P
S
S
S
S
S
S
Site 28
S82
L
S
D
D
G
S
P
S
S
S
S
S
S
S
S
Site 29
S83
S
D
D
G
S
P
S
S
S
S
S
S
S
S
S
Site 30
S84
D
D
G
S
P
S
S
S
S
S
S
S
S
S
S
Site 31
S85
D
G
S
P
S
S
S
S
S
S
S
S
S
S
S
Site 32
S86
G
S
P
S
S
S
S
S
S
S
S
S
S
S
S
Site 33
S87
S
P
S
S
S
S
S
S
S
S
S
S
S
S
F
Site 34
S88
P
S
S
S
S
S
S
S
S
S
S
S
S
F
Y
Site 35
S89
S
S
S
S
S
S
S
S
S
S
S
S
F
Y
N
Site 36
S90
S
S
S
S
S
S
S
S
S
S
S
F
Y
N
G
Site 37
S91
S
S
S
S
S
S
S
S
S
S
F
Y
N
G
S
Site 38
S92
S
S
S
S
S
S
S
S
S
F
Y
N
G
S
P
Site 39
S93
S
S
S
S
S
S
S
S
F
Y
N
G
S
P
P
Site 40
Y95
S
S
S
S
S
S
F
Y
N
G
S
P
P
G
S
Site 41
S98
S
S
S
F
Y
N
G
S
P
P
G
S
L
Q
V
Site 42
S102
Y
N
G
S
P
P
G
S
L
Q
V
A
M
E
D
Site 43
S110
L
Q
V
A
M
E
D
S
S
R
V
S
P
S
K
Site 44
S111
Q
V
A
M
E
D
S
S
R
V
S
P
S
K
S
Site 45
S114
M
E
D
S
S
R
V
S
P
S
K
S
T
S
N
Site 46
S116
D
S
S
R
V
S
P
S
K
S
T
S
N
I
T
Site 47
S118
S
R
V
S
P
S
K
S
T
S
N
I
T
K
L
Site 48
S120
V
S
P
S
K
S
T
S
N
I
T
K
L
N
G
Site 49
Y144
D
V
A
S
G
F
H
Y
G
V
H
A
C
E
G
Site 50
Y166
S
I
Q
Q
N
I
Q
Y
K
R
C
L
K
N
E
Site 51
S195
C
R
F
K
K
C
L
S
V
G
M
S
R
D
A
Site 52
S233
L
A
N
N
Q
L
S
S
Q
C
P
L
E
T
S
Site 53
S240
S
Q
C
P
L
E
T
S
P
T
Q
H
P
T
P
Site 54
T242
C
P
L
E
T
S
P
T
Q
H
P
T
P
G
P
Site 55
T246
T
S
P
T
Q
H
P
T
P
G
P
M
G
P
S
Site 56
S253
T
P
G
P
M
G
P
S
P
P
P
A
P
V
P
Site 57
S261
P
P
P
A
P
V
P
S
P
L
V
G
F
S
Q
Site 58
S267
P
S
P
L
V
G
F
S
Q
F
P
Q
Q
L
T
Site 59
T274
S
Q
F
P
Q
Q
L
T
P
P
R
S
P
S
P
Site 60
S278
Q
Q
L
T
P
P
R
S
P
S
P
E
P
T
V
Site 61
S280
L
T
P
P
R
S
P
S
P
E
P
T
V
E
D
Site 62
T284
R
S
P
S
P
E
P
T
V
E
D
V
I
S
Q
Site 63
S290
P
T
V
E
D
V
I
S
Q
V
A
R
A
H
R
Site 64
Y302
A
H
R
E
I
F
T
Y
A
H
D
K
L
G
S
Site 65
S310
A
H
D
K
L
G
S
S
P
G
N
F
N
A
N
Site 66
S320
N
F
N
A
N
H
A
S
G
S
P
P
A
T
T
Site 67
S322
N
A
N
H
A
S
G
S
P
P
A
T
T
P
H
Site 68
T326
A
S
G
S
P
P
A
T
T
P
H
R
W
E
N
Site 69
T327
S
G
S
P
P
A
T
T
P
H
R
W
E
N
Q
Site 70
T345
P
A
P
N
D
N
N
T
L
A
A
Q
R
H
N
Site 71
S363
N
G
L
R
Q
A
P
S
S
Y
P
P
T
W
P
Site 72
S364
G
L
R
Q
A
P
S
S
Y
P
P
T
W
P
P
Site 73
Y365
L
R
Q
A
P
S
S
Y
P
P
T
W
P
P
G
Site 74
T368
A
P
S
S
Y
P
P
T
W
P
P
G
P
A
H
Site 75
S377
P
P
G
P
A
H
H
S
C
H
Q
S
N
S
N
Site 76
Y394
R
L
C
P
T
H
V
Y
A
A
P
E
G
K
A
Site 77
S405
E
G
K
A
P
A
N
S
P
R
Q
G
N
S
K
Site 78
S411
N
S
P
R
Q
G
N
S
K
N
V
L
L
A
C
Site 79
Y423
L
A
C
P
M
N
M
Y
P
H
G
R
S
G
R
Site 80
S428
N
M
Y
P
H
G
R
S
G
R
T
V
Q
E
I
Site 81
S442
I
W
E
D
F
S
M
S
F
T
P
A
V
R
E
Site 82
S464
I
P
G
F
R
D
L
S
Q
H
D
Q
V
T
L
Site 83
T470
L
S
Q
H
D
Q
V
T
L
L
K
A
G
T
F
Site 84
Y503
M
F
L
S
R
T
T
Y
S
L
Q
E
L
G
A
Site 85
S504
F
L
S
R
T
T
Y
S
L
Q
E
L
G
A
M
Site 86
S529
D
F
S
E
K
L
N
S
L
A
L
T
E
E
E
Site 87
S551
V
L
V
S
A
D
R
S
G
M
E
N
S
A
S
Site 88
S556
D
R
S
G
M
E
N
S
A
S
V
E
Q
L
Q
Site 89
S558
S
G
M
E
N
S
A
S
V
E
Q
L
Q
E
T
Site 90
T565
S
V
E
Q
L
Q
E
T
L
L
R
A
L
R
A
Site 91
S583
K
N
R
P
L
E
T
S
R
F
T
K
L
L
L
Site 92
T586
P
L
E
T
S
R
F
T
K
L
L
L
K
L
P
Site 93
T597
L
K
L
P
D
L
R
T
L
N
N
M
H
S
E
Site 94
S603
R
T
L
N
N
M
H
S
E
K
L
L
S
F
R
Site 95
S608
M
H
S
E
K
L
L
S
F
R
V
D
A
Q
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation