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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ATP4A
Full Name:
Potassium-transporting ATPase alpha chain 1
Alias:
ATP6A; ATPase, H+/K+ exchanging, alpha polypeptide; Gastric H(+)/K(+) ATPase alpha; Gastric H(+)/K(+) ATPase subunit alpha; Potassium-transporting ATPase alpha 1; Proton pump
Type:
EC 3.6.3.10; Hydrolase; Energy Metabolism - oxidative phosphorylation
Mass (Da):
114119
Number AA:
1035
UniProt ID:
P20648
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005887
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0008900
GO:0000287
PhosphoSite+
KinaseNET
Biological Process:
GO:0006754
GO:0015991
GO:0006813
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y7
_
M
G
K
A
E
N
Y
E
L
Y
S
V
E
L
Site 2
Y10
K
A
E
N
Y
E
L
Y
S
V
E
L
G
P
G
Site 3
S11
A
E
N
Y
E
L
Y
S
V
E
L
G
P
G
P
Site 4
S27
G
D
M
A
A
K
M
S
K
K
K
K
A
G
G
Site 5
S58
E
I
N
D
H
Q
L
S
V
A
E
L
E
Q
K
Site 6
Y66
V
A
E
L
E
Q
K
Y
Q
T
S
A
T
K
G
Site 7
T68
E
L
E
Q
K
Y
Q
T
S
A
T
K
G
L
S
Site 8
T97
A
L
R
P
P
R
G
T
P
E
Y
V
K
F
A
Site 9
Y100
P
P
R
G
T
P
E
Y
V
K
F
A
R
Q
L
Site 10
T136
Q
A
S
E
G
D
L
T
T
D
D
N
L
Y
L
Site 11
Y160
V
T
G
C
F
G
Y
Y
Q
E
F
K
S
T
N
Site 12
S171
K
S
T
N
I
I
A
S
F
K
N
L
V
P
Q
Site 13
S227
Q
G
C
K
V
D
N
S
S
L
T
G
E
S
E
Site 14
S228
G
C
K
V
D
N
S
S
L
T
G
E
S
E
P
Site 15
T230
K
V
D
N
S
S
L
T
G
E
S
E
P
Q
T
Site 16
S233
N
S
S
L
T
G
E
S
E
P
Q
T
R
S
P
Site 17
T237
T
G
E
S
E
P
Q
T
R
S
P
E
C
T
H
Site 18
S239
E
S
E
P
Q
T
R
S
P
E
C
T
H
E
S
Site 19
T243
Q
T
R
S
P
E
C
T
H
E
S
P
L
E
T
Site 20
S246
S
P
E
C
T
H
E
S
P
L
E
T
R
N
I
Site 21
S257
T
R
N
I
A
F
F
S
T
M
C
L
E
G
T
Site 22
T272
V
Q
G
L
V
V
N
T
G
D
R
T
I
I
G
Site 23
S286
G
R
I
A
S
L
A
S
G
V
E
N
E
K
T
Site 24
T293
S
G
V
E
N
E
K
T
P
I
A
I
E
I
E
Site 25
S364
L
T
A
K
R
L
A
S
K
N
C
V
V
K
N
Site 26
S380
E
A
V
E
T
L
G
S
T
S
V
I
C
S
D
Site 27
T381
A
V
E
T
L
G
S
T
S
V
I
C
S
D
K
Site 28
S386
G
S
T
S
V
I
C
S
D
K
T
G
T
L
T
Site 29
T389
S
V
I
C
S
D
K
T
G
T
L
T
Q
N
R
Site 30
T391
I
C
S
D
K
T
G
T
L
T
Q
N
R
M
T
Site 31
T393
S
D
K
T
G
T
L
T
Q
N
R
M
T
V
S
Site 32
T413
N
H
I
H
T
A
D
T
T
E
D
Q
S
G
Q
Site 33
T414
H
I
H
T
A
D
T
T
E
D
Q
S
G
Q
T
Site 34
S418
A
D
T
T
E
D
Q
S
G
Q
T
F
D
Q
S
Site 35
T421
T
E
D
Q
S
G
Q
T
F
D
Q
S
S
E
T
Site 36
S425
S
G
Q
T
F
D
Q
S
S
E
T
W
R
A
L
Site 37
S426
G
Q
T
F
D
Q
S
S
E
T
W
R
A
L
C
Site 38
T428
T
F
D
Q
S
S
E
T
W
R
A
L
C
R
V
Site 39
S446
C
N
R
A
A
F
K
S
G
Q
D
A
V
P
V
Site 40
S463
R
I
V
I
G
D
A
S
E
T
A
L
L
K
F
Site 41
T465
V
I
G
D
A
S
E
T
A
L
L
K
F
S
E
Site 42
Y481
T
L
G
N
A
M
G
Y
R
D
R
F
P
K
V
Site 43
S495
V
C
E
I
P
F
N
S
T
N
K
F
Q
L
S
Site 44
T496
C
E
I
P
F
N
S
T
N
K
F
Q
L
S
I
Site 45
S502
S
T
N
K
F
Q
L
S
I
H
T
L
E
D
P
Site 46
S530
E
R
V
L
E
R
C
S
S
I
L
I
K
G
Q
Site 47
S531
R
V
L
E
R
C
S
S
I
L
I
K
G
Q
E
Site 48
T551
Q
W
R
E
A
F
Q
T
A
Y
L
S
L
G
G
Site 49
Y553
R
E
A
F
Q
T
A
Y
L
S
L
G
G
L
G
Site 50
Y570
V
L
G
F
C
Q
L
Y
L
N
E
K
D
Y
P
Site 51
Y576
L
Y
L
N
E
K
D
Y
P
P
G
Y
A
F
D
Site 52
Y580
E
K
D
Y
P
P
G
Y
A
F
D
V
E
A
M
Site 53
S601
L
C
F
A
G
L
V
S
M
I
D
P
P
R
A
Site 54
S646
A
A
S
V
G
I
I
S
E
G
S
E
T
V
E
Site 55
T651
I
I
S
E
G
S
E
T
V
E
D
I
A
A
R
Site 56
S687
Q
L
K
D
M
D
P
S
E
L
V
E
A
L
R
Site 57
T695
E
L
V
E
A
L
R
T
H
P
E
M
V
F
A
Site 58
S705
E
M
V
F
A
R
T
S
P
Q
Q
K
L
V
I
Site 59
S733
T
G
D
G
V
N
D
S
P
A
L
K
K
A
D
Site 60
S750
V
A
M
G
I
A
G
S
D
A
A
K
N
A
A
Site 61
S786
I
F
D
N
L
K
K
S
I
A
Y
T
L
T
K
Site 62
T790
L
K
K
S
I
A
Y
T
L
T
K
N
I
P
E
Site 63
S840
L
A
Y
E
K
A
E
S
D
I
M
H
L
R
P
Site 64
Y880
S
F
A
G
F
T
D
Y
F
T
A
M
A
Q
E
Site 65
Y913
L
Q
D
L
Q
D
S
Y
G
Q
E
W
T
F
G
Site 66
T918
D
S
Y
G
Q
E
W
T
F
G
Q
R
L
Y
Q
Site 67
Y927
G
Q
R
L
Y
Q
Q
Y
T
C
Y
T
V
F
F
Site 68
T950
A
D
V
L
I
R
K
T
R
R
L
S
A
F
Q
Site 69
S954
I
R
K
T
R
R
L
S
A
F
Q
Q
G
F
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation