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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PZP
Full Name:
Pregnancy zone protein
Alias:
A2M; CPAMD6; MGC133093; pregnancy-zone protein
Type:
Mass (Da):
163840
Number AA:
UniProt ID:
P20742
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005615
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0004867
PhosphoSite+
KinaseNET
Biological Process:
GO:0007565
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S23
I
L
L
S
A
S
D
S
N
S
T
E
P
Q
Y
Site 2
S25
L
S
A
S
D
S
N
S
T
E
P
Q
Y
M
V
Site 3
Y30
S
N
S
T
E
P
Q
Y
M
V
L
V
P
S
L
Site 4
T40
L
V
P
S
L
L
H
T
E
A
P
K
K
G
C
Site 5
T58
S
H
L
N
E
T
V
T
V
S
A
S
L
E
S
Site 6
S60
L
N
E
T
V
T
V
S
A
S
L
E
S
G
R
Site 7
S62
E
T
V
T
V
S
A
S
L
E
S
G
R
E
N
Site 8
S65
T
V
S
A
S
L
E
S
G
R
E
N
R
S
L
Site 9
S71
E
S
G
R
E
N
R
S
L
F
T
D
L
V
A
Site 10
T118
Q
D
F
R
K
R
N
T
V
L
V
L
N
T
Q
Site 11
T132
Q
S
L
V
F
V
Q
T
D
K
P
M
Y
K
P
Site 12
Y137
V
Q
T
D
K
P
M
Y
K
P
G
Q
T
V
R
Site 13
T142
P
M
Y
K
P
G
Q
T
V
R
F
R
V
V
S
Site 14
S149
T
V
R
F
R
V
V
S
V
D
E
N
F
R
P
Site 15
Y165
N
E
L
I
P
L
I
Y
L
E
N
P
R
R
N
Site 16
S190
E
A
G
I
N
Q
L
S
F
P
L
S
S
E
P
Site 17
S194
N
Q
L
S
F
P
L
S
S
E
P
I
Q
G
S
Site 18
S195
Q
L
S
F
P
L
S
S
E
P
I
Q
G
S
Y
Site 19
S201
S
S
E
P
I
Q
G
S
Y
R
V
V
V
Q
T
Site 20
T208
S
Y
R
V
V
V
Q
T
E
S
G
G
R
I
Q
Site 21
S210
R
V
V
V
Q
T
E
S
G
G
R
I
Q
H
P
Site 22
T219
G
R
I
Q
H
P
F
T
V
E
E
F
V
L
P
Site 23
T248
M
D
E
K
V
N
I
T
V
C
G
E
Y
T
Y
Site 24
Y255
T
V
C
G
E
Y
T
Y
G
K
P
V
P
G
L
Site 25
S272
V
S
L
C
R
K
L
S
R
V
L
N
C
D
K
Site 26
S287
Q
E
V
C
E
E
F
S
Q
Q
L
N
S
N
G
Site 27
T340
A
N
R
I
S
E
I
T
N
I
V
S
K
L
K
Site 28
S353
L
K
F
V
K
V
D
S
H
F
R
Q
G
I
P
Site 29
Y389
I
S
V
N
D
A
N
Y
Y
S
N
A
T
T
N
Site 30
T395
N
Y
Y
S
N
A
T
T
N
E
Q
G
L
A
Q
Site 31
S404
E
Q
G
L
A
Q
F
S
I
N
T
T
S
I
S
Site 32
S449
H
T
A
N
R
V
F
S
L
S
G
S
Y
I
H
Site 33
S451
A
N
R
V
F
S
L
S
G
S
Y
I
H
L
E
Site 34
T469
G
T
L
P
C
G
H
T
E
T
I
T
A
H
Y
Site 35
T473
C
G
H
T
E
T
I
T
A
H
Y
T
L
N
R
Site 36
T477
E
T
I
T
A
H
Y
T
L
N
R
Q
A
M
G
Site 37
S487
R
Q
A
M
G
E
L
S
E
L
S
F
H
Y
L
Site 38
T508
I
V
R
S
G
T
H
T
L
P
V
E
S
G
D
Site 39
S519
E
S
G
D
M
K
G
S
F
A
L
S
F
P
V
Site 40
S551
D
G
E
V
V
G
D
S
E
K
F
E
I
E
N
Site 41
S567
L
A
N
K
V
D
L
S
F
S
P
A
Q
S
P
Site 42
S569
N
K
V
D
L
S
F
S
P
A
Q
S
P
P
A
Site 43
S573
L
S
F
S
P
A
Q
S
P
P
A
S
H
A
H
Site 44
S577
P
A
Q
S
P
P
A
S
H
A
H
L
Q
V
A
Site 45
S610
M
K
P
E
A
E
L
S
V
S
S
V
Y
N
L
Site 46
T624
L
L
T
V
K
D
L
T
N
F
P
D
N
V
D
Site 47
Y663
S
S
N
E
A
D
I
Y
S
F
L
K
G
M
G
Site 48
S664
S
N
E
A
D
I
Y
S
F
L
K
G
M
G
L
Site 49
S677
G
L
K
V
F
T
N
S
K
I
R
K
P
K
S
Site 50
S684
S
K
I
R
K
P
K
S
C
S
V
I
P
S
V
Site 51
S686
I
R
K
P
K
S
C
S
V
I
P
S
V
S
A
Site 52
Y700
A
G
A
V
G
Q
G
Y
Y
G
A
G
L
G
V
Site 53
Y701
G
A
V
G
Q
G
Y
Y
G
A
G
L
G
V
V
Site 54
S729
I
P
L
N
N
E
Q
S
S
G
P
V
P
E
T
Site 55
T736
S
S
G
P
V
P
E
T
V
R
S
Y
F
P
E
Site 56
S739
P
V
P
E
T
V
R
S
Y
F
P
E
T
W
I
Site 57
Y740
V
P
E
T
V
R
S
Y
F
P
E
T
W
I
W
Site 58
S787
E
D
A
G
L
G
I
S
S
T
A
S
L
R
A
Site 59
Y823
L
K
A
T
V
L
N
Y
L
P
K
C
I
R
V
Site 60
S843
A
S
P
A
F
L
A
S
Q
N
T
K
G
E
E
Site 61
Y852
N
T
K
G
E
E
S
Y
C
I
C
G
S
E
R
Site 62
T861
I
C
G
S
E
R
Q
T
L
S
W
T
V
T
P
Site 63
S863
G
S
E
R
Q
T
L
S
W
T
V
T
P
K
T
Site 64
T865
E
R
Q
T
L
S
W
T
V
T
P
K
T
L
G
Site 65
T867
Q
T
L
S
W
T
V
T
P
K
T
L
G
N
V
Site 66
T870
S
W
T
V
T
P
K
T
L
G
N
V
N
F
S
Site 67
S885
V
S
A
E
A
M
Q
S
L
E
L
C
G
N
E
Site 68
T904
P
E
I
K
R
K
D
T
V
I
K
T
L
L
V
Site 69
T908
R
K
D
T
V
I
K
T
L
L
V
E
A
E
G
Site 70
T921
E
G
I
E
Q
E
K
T
F
S
S
M
T
C
A
Site 71
S923
I
E
Q
E
K
T
F
S
S
M
T
C
A
S
G
Site 72
S924
E
Q
E
K
T
F
S
S
M
T
C
A
S
G
A
Site 73
S929
F
S
S
M
T
C
A
S
G
A
N
V
S
E
Q
Site 74
S938
A
N
V
S
E
Q
L
S
L
K
L
P
S
N
V
Site 75
S943
Q
L
S
L
K
L
P
S
N
V
V
K
E
S
A
Site 76
S949
P
S
N
V
V
K
E
S
A
R
A
S
F
S
V
Site 77
Y976
Q
N
L
L
Q
M
P
Y
G
C
G
E
Q
N
M
Site 78
Y995
P
N
I
Y
V
L
N
Y
L
N
E
T
Q
Q
L
Site 79
Y1018
V
G
Y
L
I
T
G
Y
Q
R
Q
L
N
Y
K
Site 80
Y1024
G
Y
Q
R
Q
L
N
Y
K
H
Q
D
G
S
Y
Site 81
S1030
N
Y
K
H
Q
D
G
S
Y
S
T
F
G
E
R
Site 82
Y1031
Y
K
H
Q
D
G
S
Y
S
T
F
G
E
R
Y
Site 83
S1032
K
H
Q
D
G
S
Y
S
T
F
G
E
R
Y
G
Site 84
T1033
H
Q
D
G
S
Y
S
T
F
G
E
R
Y
G
R
Site 85
Y1038
Y
S
T
F
G
E
R
Y
G
R
N
Q
G
N
T
Site 86
Y1061
T
F
A
Q
A
R
S
Y
I
F
I
D
E
A
H
Site 87
S1072
D
E
A
H
I
T
Q
S
L
T
W
L
S
Q
M
Site 88
T1074
A
H
I
T
Q
S
L
T
W
L
S
Q
M
Q
K
Site 89
S1077
T
Q
S
L
T
W
L
S
Q
M
Q
K
D
N
G
Site 90
S1088
K
D
N
G
C
F
R
S
S
G
S
L
L
N
N
Site 91
S1089
D
N
G
C
F
R
S
S
G
S
L
L
N
N
A
Site 92
S1091
G
C
F
R
S
S
G
S
L
L
N
N
A
I
K
Site 93
S1148
A
K
E
G
T
H
G
S
H
V
Y
T
K
A
L
Site 94
S1175
Q
N
R
E
I
L
N
S
L
D
K
E
A
V
K
Site 95
Y1203
K
A
P
V
G
H
L
Y
Q
P
Q
A
P
S
A
Site 96
S1231
T
A
Q
P
A
P
T
S
G
D
L
T
S
A
T
Site 97
T1235
A
P
T
S
G
D
L
T
S
A
T
N
I
V
K
Site 98
S1236
P
T
S
G
D
L
T
S
A
T
N
I
V
K
W
Site 99
T1274
L
S
R
Y
G
A
A
T
F
T
R
T
E
K
T
Site 100
T1285
T
E
K
T
A
Q
V
T
V
Q
D
S
Q
T
F
Site 101
S1289
A
Q
V
T
V
Q
D
S
Q
T
F
S
T
N
F
Site 102
T1291
V
T
V
Q
D
S
Q
T
F
S
T
N
F
Q
V
Site 103
S1293
V
Q
D
S
Q
T
F
S
T
N
F
Q
V
D
N
Site 104
Y1329
V
T
G
E
R
C
V
Y
L
Q
T
S
M
K
Y
Site 105
S1345
I
L
P
E
K
E
D
S
P
F
A
L
K
V
Q
Site 106
S1366
D
G
H
K
A
H
T
S
F
Q
I
S
L
T
I
Site 107
T1372
T
S
F
Q
I
S
L
T
I
S
Y
T
G
N
R
Site 108
S1374
F
Q
I
S
L
T
I
S
Y
T
G
N
R
P
A
Site 109
T1376
I
S
L
T
I
S
Y
T
G
N
R
P
A
S
N
Site 110
S1382
Y
T
G
N
R
P
A
S
N
M
V
I
V
D
V
Site 111
S1393
I
V
D
V
K
M
V
S
G
F
I
P
L
K
P
Site 112
T1401
G
F
I
P
L
K
P
T
V
K
M
L
E
R
S
Site 113
S1408
T
V
K
M
L
E
R
S
S
S
V
S
R
T
E
Site 114
S1409
V
K
M
L
E
R
S
S
S
V
S
R
T
E
V
Site 115
S1410
K
M
L
E
R
S
S
S
V
S
R
T
E
V
S
Site 116
S1412
L
E
R
S
S
S
V
S
R
T
E
V
S
N
N
Site 117
T1414
R
S
S
S
V
S
R
T
E
V
S
N
N
H
V
Site 118
S1417
S
V
S
R
T
E
V
S
N
N
H
V
L
I
Y
Site 119
Y1424
S
N
N
H
V
L
I
Y
V
E
Q
V
T
N
Q
Site 120
Y1458
A
I
V
K
V
Y
D
Y
Y
E
T
D
E
S
V
Site 121
Y1459
I
V
K
V
Y
D
Y
Y
E
T
D
E
S
V
V
Site 122
S1464
D
Y
Y
E
T
D
E
S
V
V
A
E
Y
I
A
Site 123
Y1469
D
E
S
V
V
A
E
Y
I
A
P
C
S
T
D
Site 124
S1474
A
E
Y
I
A
P
C
S
T
D
T
E
H
G
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation