PhosphoNET

           
Protein Info 
   
Short Name:  MAK
Full Name:  Serine/threonine-protein kinase MAK
Alias:  EC 2.7.11.22; Male germ cell-associated kinase
Type:  Protein-serine kinase, CMGC group, RCK family
Mass (Da):  70581
Number AA:  623
UniProt ID:  P20794
International Prot ID:  IPI00025489
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:      Uniprot OncoNet
Molecular Function:  GO:0005524  GO:0004693   PhosphoSite+ KinaseNET
Biological Process:  GO:0030154  GO:0007275  GO:0006468 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1T5___MNRYTTMRQLGD
Site 2T14MRQLGDGTYGSVLMG
Site 3Y15RQLGDGTYGSVLMGK
Site 4S17LGDGTYGSVLMGKSN
Site 5S23GSVLMGKSNESGELV
Site 6S53MNLREVKSLKKLNHA
Site 7Y76IRENDHLYFIFEYMK
Site 8Y81HLYFIFEYMKENLYQ
Site 9Y87EYMKENLYQLMKDRN
Site 10S152GLARELRSQPPYTDY
Site 11Y156ELRSQPPYTDYVSTR
Site 12T157LRSQPPYTDYVSTRW
Site 13Y159SQPPYTDYVSTRWYR
Site 14S161PPYTDYVSTRWYRAP
Site 15T162PYTDYVSTRWYRAPE
Site 16Y165DYVSTRWYRAPEVLL
Site 17S175PEVLLRSSVYSSPID
Site 18S204RPLFPGTSEVDEIFK
Site 19T218KICQVLGTPKKSDWP
Site 20S222VLGTPKKSDWPEGYQ
Site 21Y228KSDWPEGYQLASSMN
Site 22S232PEGYQLASSMNFRFP
Site 23S233EGYQLASSMNFRFPQ
Site 24S254KTLIPNASNEAIQLM
Site 25T274WDPKKRPTASQALKH
Site 26S276PKKRPTASQALKHPY
Site 27Y283SQALKHPYFQVGQVL
Site 28S293VGQVLGPSSNHLESK
Site 29S294GQVLGPSSNHLESKQ
Site 30S299PSSNHLESKQSLNKQ
Site 31S302NHLESKQSLNKQLQP
Site 32S312KQLQPLESKPSLVEV
Site 33S315QPLESKPSLVEVEPK
Site 34T339VGQPQPKTSQQPLQP
Site 35S340GQPQPKTSQQPLQPI
Site 36S354IQPPQNLSVQQPPKQ
Site 37S363QQPPKQQSQEKPPQT
Site 38T370SQEKPPQTLFPSIVK
Site 39S374PPQTLFPSIVKNMPT
Site 40T386MPTKPNGTLSHKSGR
Site 41S388TKPNGTLSHKSGRRR
Site 42S391NGTLSHKSGRRRWGQ
Site 43T399GRRRWGQTIFKSGDS
Site 44S406TIFKSGDSWEELEDY
Site 45Y413SWEELEDYDFGASHS
Site 46S418EDYDFGASHSKKPSM
Site 47S420YDFGASHSKKPSMGV
Site 48S424ASHSKKPSMGVFKEK
Site 49S436KEKRKKDSPFRLPEP
Site 50S446RLPEPVPSGSNHSTG
Site 51S448PEPVPSGSNHSTGEN
Site 52T452PSGSNHSTGENKSLP
Site 53S457HSTGENKSLPAVTSL
Site 54S463KSLPAVTSLKSDSEL
Site 55S466PAVTSLKSDSELSTA
Site 56S468VTSLKSDSELSTAPT
Site 57S471LKSDSELSTAPTSKQ
Site 58T472KSDSELSTAPTSKQY
Site 59T475SELSTAPTSKQYYLK
Site 60S476ELSTAPTSKQYYLKQ
Site 61Y480APTSKQYYLKQSRYL
Site 62Y486YYLKQSRYLPGVNPK
Site 63S496GVNPKKVSLIASGKE
Site 64S500KKVSLIASGKEINPH
Site 65T508GKEINPHTWSNQLFP
Site 66S517SNQLFPKSLGPVGAE
Site 67S530AELAFKRSNAGNLGS
Site 68S537SNAGNLGSYATYNQS
Site 69T540GNLGSYATYNQSGYI
Site 70Y541NLGSYATYNQSGYIP
Site 71Y546ATYNQSGYIPSFLKK
Site 72S549NQSGYIPSFLKKEVQ
Site 73S572APLNATASEYTWNTK
Site 74T580EYTWNTKTGRGQFSG
Site 75S586KTGRGQFSGRTYNPT
Site 76T589RGQFSGRTYNPTAKN
Site 77Y590GQFSGRTYNPTAKNL
Site 78T593SGRTYNPTAKNLNIV
Site 79S608NRAQPIPSVHGRTDW
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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