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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CYP2B1
Full Name:
Cytochrome P450 2B6
Alias:
CYPIIB6;Cytochrome P450 IIB1
Type:
Cytochrome
Mass (Da):
56278
Number AA:
491
UniProt ID:
P20813
International Prot ID:
IPI00025829
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005789
GO:0019898
GO:0005792
Uniprot
OncoNet
Molecular Function:
GO:0070330
GO:0009055
GO:0020037
PhosphoSite+
KinaseNET
Biological Process:
GO:0055114
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T26
L
V
Q
R
H
P
N
T
H
D
R
L
P
P
G
Site 2
S54
D
R
R
G
L
L
K
S
F
L
R
F
R
E
K
Site 3
Y62
F
L
R
F
R
E
K
Y
G
D
V
F
T
V
H
Site 4
T67
E
K
Y
G
D
V
F
T
V
H
L
G
P
R
P
Site 5
S96
V
D
K
A
E
A
F
S
G
R
G
K
I
A
M
Site 6
S128
W
K
V
L
R
R
F
S
V
T
T
M
R
D
F
Site 7
T131
L
R
R
F
S
V
T
T
M
R
D
F
G
M
G
Site 8
S141
D
F
G
M
G
K
R
S
V
E
E
R
I
Q
E
Site 9
S160
L
I
E
E
L
R
K
S
K
G
A
L
M
D
P
Site 10
Y190
V
F
G
K
R
F
H
Y
Q
D
Q
E
F
L
K
Site 11
Y226
L
F
S
G
F
L
K
Y
F
P
G
A
H
R
Q
Site 12
Y235
P
G
A
H
R
Q
V
Y
K
N
L
Q
E
I
N
Site 13
Y244
N
L
Q
E
I
N
A
Y
I
G
H
S
V
E
K
Site 14
T255
S
V
E
K
H
R
E
T
L
D
P
S
A
P
K
Site 15
T267
A
P
K
D
L
I
D
T
Y
L
L
H
M
E
K
Site 16
Y268
P
K
D
L
I
D
T
Y
L
L
H
M
E
K
E
Site 17
S277
L
H
M
E
K
E
K
S
N
A
H
S
E
F
S
Site 18
S281
K
E
K
S
N
A
H
S
E
F
S
H
Q
N
L
Site 19
T305
A
G
T
E
T
T
S
T
T
L
R
Y
G
F
L
Site 20
T306
G
T
E
T
T
S
T
T
L
R
Y
G
F
L
L
Site 21
Y325
P
H
V
A
E
R
V
Y
R
E
I
E
Q
V
I
Site 22
Y348
H
D
R
A
K
M
P
Y
T
E
A
V
I
Y
E
Site 23
T349
D
R
A
K
M
P
Y
T
E
A
V
I
Y
E
I
Site 24
Y354
P
Y
T
E
A
V
I
Y
E
I
Q
R
F
S
D
Site 25
T372
M
G
V
P
H
I
V
T
Q
H
T
S
F
R
G
Site 26
Y380
Q
H
T
S
F
R
G
Y
I
I
P
K
D
T
E
Site 27
Y401
T
A
L
H
D
P
H
Y
F
E
K
P
D
A
F
Site 28
T423
A
N
G
A
L
K
K
T
E
A
F
I
P
F
S
Site 29
S461
L
Q
N
F
S
M
A
S
P
V
A
P
E
D
I
Site 30
T471
A
P
E
D
I
D
L
T
P
Q
E
C
G
V
G
Site 31
T483
G
V
G
K
I
P
P
T
Y
Q
I
R
F
L
P
Site 32
Y484
V
G
K
I
P
P
T
Y
Q
I
R
F
L
P
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation