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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CYP2A7
Full Name:
Cytochrome P450 2A7
Alias:
CYPIIA7;Cytochrome P450 IIA4
Type:
Mass (Da):
56425
Number AA:
494
UniProt ID:
P20853
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S29
S
V
W
Q
Q
R
K
S
R
G
K
L
P
P
G
Site 2
T38
G
K
L
P
P
G
P
T
P
L
P
F
I
G
N
Site 3
Y46
P
L
P
F
I
G
N
Y
L
Q
L
N
T
E
H
Site 4
S99
V
D
Q
A
E
E
F
S
G
R
G
E
Q
A
T
Site 5
T106
S
G
R
G
E
Q
A
T
F
D
W
V
F
K
G
Site 6
S119
K
G
Y
G
V
A
F
S
N
G
E
R
A
K
Q
Site 7
S153
E
E
R
I
Q
E
E
S
G
F
L
I
E
A
I
Site 8
T163
L
I
E
A
I
R
S
T
H
G
A
N
I
D
P
Site 9
T171
H
G
A
N
I
D
P
T
F
F
L
S
R
T
V
Site 10
Y193
V
F
G
D
R
F
D
Y
E
D
K
E
F
L
S
Site 11
S215
I
F
Q
F
T
S
T
S
T
G
Q
L
Y
E
M
Site 12
Y220
S
T
S
T
G
Q
L
Y
E
M
F
S
S
V
M
Site 13
S224
G
Q
L
Y
E
M
F
S
S
V
M
K
H
L
P
Site 14
S225
Q
L
Y
E
M
F
S
S
V
M
K
H
L
P
G
Site 15
T258
K
V
E
H
N
Q
R
T
L
D
P
N
S
P
Q
Site 16
S263
Q
R
T
L
D
P
N
S
P
Q
D
F
I
D
S
Site 17
Y287
K
N
P
N
T
E
F
Y
L
K
N
L
M
M
S
Site 18
T347
Q
P
K
F
E
D
R
T
K
M
P
Y
M
E
A
Site 19
Y351
E
D
R
T
K
M
P
Y
M
E
A
V
I
H
E
Site 20
S369
F
G
D
V
I
P
M
S
L
A
R
R
V
K
K
Site 21
T378
A
R
R
V
K
K
D
T
K
F
R
D
F
F
L
Site 22
S403
G
S
V
L
R
D
P
S
F
F
S
N
P
Q
D
Site 23
S426
D
K
G
Q
F
K
K
S
D
A
F
V
P
F
S
Site 24
S464
M
Q
N
F
R
L
K
S
S
Q
S
P
K
D
I
Site 25
S465
Q
N
F
R
L
K
S
S
Q
S
P
K
D
I
D
Site 26
S467
F
R
L
K
S
S
Q
S
P
K
D
I
D
V
S
Site 27
S474
S
P
K
D
I
D
V
S
P
K
H
V
V
F
A
Site 28
T482
P
K
H
V
V
F
A
T
I
P
R
N
Y
T
M
Site 29
Y487
F
A
T
I
P
R
N
Y
T
M
S
F
L
P
R
Site 30
T488
A
T
I
P
R
N
Y
T
M
S
F
L
P
R
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation