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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RASA1
Full Name:
Ras GTPase-activating protein 1
Alias:
Capillary malformation-arteriovenous malformation; CM-AVM; GAP; GTPase-activating protein; P120GAP; P120RASGAP; Ras p21 protein activator; RAS p21 protein activator (GTPase activating protein) 1; RASA
Type:
GTPase-activating protein for G protein
Mass (Da):
116403
Number AA:
1047
UniProt ID:
P20936
International Prot ID:
IPI00026262
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0051020
GO:0005099
GO:0001948
PhosphoSite+
KinaseNET
Biological Process:
GO:0000910
GO:0009790
GO:0007242
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T15
S
E
E
G
G
P
V
T
A
G
A
G
G
G
G
Site 2
Y142
P
P
L
P
P
P
P
Y
L
P
P
L
G
A
G
Site 3
S158
G
T
V
D
E
G
D
S
L
D
G
P
E
Y
E
Site 4
Y164
D
S
L
D
G
P
E
Y
E
E
E
E
V
A
I
Site 5
T174
E
E
V
A
I
P
L
T
A
P
P
T
N
Q
W
Site 6
T189
Y
H
G
K
L
D
R
T
I
A
E
E
R
L
R
Site 7
S201
R
L
R
Q
A
G
K
S
G
S
Y
L
I
R
E
Site 8
S203
R
Q
A
G
K
S
G
S
Y
L
I
R
E
S
D
Site 9
S209
G
S
Y
L
I
R
E
S
D
R
R
P
G
S
F
Site 10
S215
E
S
D
R
R
P
G
S
F
V
L
S
F
L
S
Site 11
Y239
I
I
A
M
C
G
D
Y
Y
I
G
G
R
R
F
Site 12
Y240
I
A
M
C
G
D
Y
Y
I
G
G
R
R
F
S
Site 13
S247
Y
I
G
G
R
R
F
S
S
L
S
D
L
I
G
Site 14
S248
I
G
G
R
R
F
S
S
L
S
D
L
I
G
Y
Site 15
S250
G
R
R
F
S
S
L
S
D
L
I
G
Y
Y
S
Site 16
S260
I
G
Y
Y
S
H
V
S
C
L
L
K
G
E
K
Site 17
Y270
L
K
G
E
K
L
L
Y
P
V
A
P
P
E
P
Site 18
Y290
R
V
R
A
I
L
P
Y
T
K
V
P
D
T
D
Site 19
T291
V
R
A
I
L
P
Y
T
K
V
P
D
T
D
E
Site 20
T296
P
Y
T
K
V
P
D
T
D
E
I
S
F
L
K
Site 21
S300
V
P
D
T
D
E
I
S
F
L
K
G
D
M
F
Site 22
S379
C
S
F
L
V
R
P
S
D
N
T
P
G
D
Y
Site 23
T382
L
V
R
P
S
D
N
T
P
G
D
Y
S
L
Y
Site 24
Y386
S
D
N
T
P
G
D
Y
S
L
Y
F
R
T
N
Site 25
S387
D
N
T
P
G
D
Y
S
L
Y
F
R
T
N
E
Site 26
Y389
T
P
G
D
Y
S
L
Y
F
R
T
N
E
N
I
Site 27
Y415
Q
F
M
M
G
G
R
Y
Y
N
S
I
G
D
I
Site 28
Y426
I
G
D
I
I
D
H
Y
R
K
E
Q
I
V
E
Site 29
T453
Q
E
Q
V
L
N
D
T
V
D
G
K
E
I
Y
Site 30
Y460
T
V
D
G
K
E
I
Y
N
T
I
R
R
K
T
Site 31
T462
D
G
K
E
I
Y
N
T
I
R
R
K
T
K
D
Site 32
T467
Y
N
T
I
R
R
K
T
K
D
A
F
Y
K
N
Site 33
Y472
R
K
T
K
D
A
F
Y
K
N
I
V
K
K
G
Site 34
Y480
K
N
I
V
K
K
G
Y
L
L
K
K
G
K
G
Site 35
Y494
G
K
R
W
K
N
L
Y
F
I
L
E
G
S
D
Site 36
Y506
G
S
D
A
Q
L
I
Y
F
E
S
E
K
R
A
Site 37
S509
A
Q
L
I
Y
F
E
S
E
K
R
A
T
K
P
Site 38
T514
F
E
S
E
K
R
A
T
K
P
K
G
L
I
D
Site 39
S533
S
V
Y
V
V
H
D
S
L
F
G
R
P
N
C
Site 40
Y553
Q
H
F
S
E
E
H
Y
I
F
Y
F
A
G
E
Site 41
Y556
S
E
E
H
Y
I
F
Y
F
A
G
E
T
P
E
Site 42
T561
I
F
Y
F
A
G
E
T
P
E
Q
A
E
D
W
Site 43
S581
A
F
C
N
L
R
K
S
S
P
G
T
S
N
K
Site 44
S582
F
C
N
L
R
K
S
S
P
G
T
S
N
K
R
Site 45
T585
L
R
K
S
S
P
G
T
S
N
K
R
L
R
Q
Site 46
S586
R
K
S
S
P
G
T
S
N
K
R
L
R
Q
V
Site 47
S594
N
K
R
L
R
Q
V
S
S
L
V
L
H
I
E
Site 48
S595
K
R
L
R
Q
V
S
S
L
V
L
H
I
E
E
Site 49
T612
K
L
P
V
K
H
F
T
N
P
Y
C
N
I
Y
Site 50
Y615
V
K
H
F
T
N
P
Y
C
N
I
Y
L
N
S
Site 51
Y619
T
N
P
Y
C
N
I
Y
L
N
S
V
Q
V
A
Site 52
T628
N
S
V
Q
V
A
K
T
H
A
R
E
G
Q
N
Site 53
S659
N
R
F
E
I
T
L
S
N
K
T
K
K
S
K
Site 54
S665
L
S
N
K
T
K
K
S
K
D
P
D
I
L
F
Site 55
S678
L
F
M
R
C
Q
L
S
R
L
Q
K
G
H
A
Site 56
T686
R
L
Q
K
G
H
A
T
D
E
W
F
L
L
S
Site 57
S693
T
D
E
W
F
L
L
S
S
H
I
P
L
K
G
Site 58
S705
L
K
G
I
E
P
G
S
L
R
V
R
A
R
Y
Site 59
Y712
S
L
R
V
R
A
R
Y
S
M
E
K
I
M
P
Site 60
S713
L
R
V
R
A
R
Y
S
M
E
K
I
M
P
E
Site 61
S724
I
M
P
E
E
E
Y
S
E
F
K
E
L
I
L
Site 62
S754
Q
D
R
T
L
L
A
S
I
L
L
R
I
F
L
Site 63
S779
T
L
N
D
R
E
I
S
M
E
D
E
A
T
T
Site 64
T785
I
S
M
E
D
E
A
T
T
L
F
R
A
T
T
Site 65
S824
S
I
L
K
I
M
E
S
K
Q
S
C
E
L
S
Site 66
S827
K
I
M
E
S
K
Q
S
C
E
L
S
P
S
K
Site 67
S831
S
K
Q
S
C
E
L
S
P
S
K
L
E
K
N
Site 68
S833
Q
S
C
E
L
S
P
S
K
L
E
K
N
E
D
Site 69
T843
E
K
N
E
D
V
N
T
N
L
T
H
L
L
N
Site 70
Y874
P
P
T
L
R
Y
I
Y
G
C
L
Q
K
S
V
Site 71
T893
P
T
N
T
T
M
R
T
R
V
V
S
G
F
V
Site 72
S919
P
R
M
F
N
I
I
S
D
S
P
S
P
I
A
Site 73
Y952
E
F
G
A
K
E
P
Y
M
E
G
V
N
P
F
Site 74
T983
N
V
P
E
L
P
D
T
T
E
H
S
R
T
D
Site 75
S987
L
P
D
T
T
E
H
S
R
T
D
L
S
R
D
Site 76
T989
D
T
T
E
H
S
R
T
D
L
S
R
D
L
A
Site 77
S1006
H
E
I
C
V
A
H
S
D
E
L
R
T
L
S
Site 78
S1013
S
D
E
L
R
T
L
S
N
E
R
G
A
Q
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation