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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ATP6V1B2
Full Name:
V-type proton ATPase subunit B, brain isoform
Alias:
ATP6B2; EC 3.6.3.14; Endomembrane proton pump 58 kDa; HO57; Vacuolar H[+]-ATPase B subunit; Vacuolar proton pump subunit B2; VATB2; V-ATPase subunit B 2
Type:
Enzyme, hydrolase
Mass (Da):
56501
Number AA:
511
UniProt ID:
P21281
International Prot ID:
IPI00007812
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0005829
GO:0019898
Uniprot
OncoNet
Molecular Function:
GO:0046933
GO:0046961
PhosphoSite+
KinaseNET
Biological Process:
GO:0015986
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S36
R
E
Q
A
L
A
V
S
R
N
Y
L
S
Q
P
Site 2
Y39
A
L
A
V
S
R
N
Y
L
S
Q
P
R
L
T
Site 3
S41
A
V
S
R
N
Y
L
S
Q
P
R
L
T
Y
K
Site 4
T46
Y
L
S
Q
P
R
L
T
Y
K
T
V
S
G
V
Site 5
Y47
L
S
Q
P
R
L
T
Y
K
T
V
S
G
V
N
Site 6
T49
Q
P
R
L
T
Y
K
T
V
S
G
V
N
G
P
Site 7
S51
R
L
T
Y
K
T
V
S
G
V
N
G
P
L
V
Site 8
Y68
D
H
V
K
F
P
R
Y
A
E
I
V
H
L
T
Site 9
T75
Y
A
E
I
V
H
L
T
L
P
D
G
T
K
R
Site 10
T80
H
L
T
L
P
D
G
T
K
R
S
G
Q
V
L
Site 11
S83
L
P
D
G
T
K
R
S
G
Q
V
L
E
V
S
Site 12
S103
V
Q
V
F
E
G
T
S
G
I
D
A
K
K
T
Site 13
T110
S
G
I
D
A
K
K
T
S
C
E
F
T
G
D
Site 14
S124
D
I
L
R
T
P
V
S
E
D
M
L
G
R
V
Site 15
S135
L
G
R
V
F
N
G
S
G
K
P
I
D
R
G
Site 16
Y165
I
N
P
Q
C
R
I
Y
P
E
E
M
I
Q
T
Site 17
T172
Y
P
E
E
M
I
Q
T
G
I
S
A
I
D
G
Site 18
S216
Q
A
G
L
V
K
K
S
K
D
V
V
D
Y
S
Site 19
Y222
K
S
K
D
V
V
D
Y
S
E
E
N
F
A
I
Site 20
S223
S
K
D
V
V
D
Y
S
E
E
N
F
A
I
V
Site 21
T240
A
M
G
V
N
M
E
T
A
R
F
F
K
S
D
Site 22
S246
E
T
A
R
F
F
K
S
D
F
E
E
N
G
S
Site 23
S253
S
D
F
E
E
N
G
S
M
D
N
V
C
L
F
Site 24
T268
L
N
L
A
N
D
P
T
I
E
R
I
I
T
P
Site 25
Y287
T
T
A
E
F
L
A
Y
Q
C
E
K
H
V
L
Site 26
T298
K
H
V
L
V
I
L
T
D
M
S
S
Y
A
E
Site 27
S311
A
E
A
L
R
E
V
S
A
A
R
E
E
V
P
Site 28
Y326
G
R
R
G
F
P
G
Y
M
Y
T
D
L
A
T
Site 29
Y328
R
G
F
P
G
Y
M
Y
T
D
L
A
T
I
Y
Site 30
T329
G
F
P
G
Y
M
Y
T
D
L
A
T
I
Y
E
Site 31
T333
Y
M
Y
T
D
L
A
T
I
Y
E
R
A
G
R
Site 32
Y335
Y
T
D
L
A
T
I
Y
E
R
A
G
R
V
E
Site 33
S347
R
V
E
G
R
N
G
S
I
T
Q
I
P
I
L
Site 34
T349
E
G
R
N
G
S
I
T
Q
I
P
I
L
T
M
Site 35
T362
T
M
P
N
D
D
I
T
H
P
I
P
D
L
T
Site 36
T369
T
H
P
I
P
D
L
T
G
Y
I
T
E
G
Q
Site 37
Y371
P
I
P
D
L
T
G
Y
I
T
E
G
Q
I
Y
Site 38
Y378
Y
I
T
E
G
Q
I
Y
V
D
R
Q
L
H
N
Site 39
Y389
Q
L
H
N
R
Q
I
Y
P
P
I
N
V
L
P
Site 40
S397
P
P
I
N
V
L
P
S
L
S
R
L
M
K
S
Site 41
S399
I
N
V
L
P
S
L
S
R
L
M
K
S
A
I
Site 42
S404
S
L
S
R
L
M
K
S
A
I
G
E
G
M
T
Site 43
S446
V
G
E
E
A
L
T
S
D
D
L
L
Y
L
E
Site 44
T472
Q
G
P
Y
E
N
R
T
V
F
E
T
L
D
I
Site 45
T476
E
N
R
T
V
F
E
T
L
D
I
G
W
Q
L
Site 46
S498
M
L
K
R
I
P
Q
S
T
L
S
E
F
Y
P
Site 47
T499
L
K
R
I
P
Q
S
T
L
S
E
F
Y
P
R
Site 48
S501
R
I
P
Q
S
T
L
S
E
F
Y
P
R
D
S
Site 49
Y504
Q
S
T
L
S
E
F
Y
P
R
D
S
A
K
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation