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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FLNA
Full Name:
Filamin-A
Alias:
ABP-280; Actin-binding protein 280; Alpha-filamin; Endothelial actin-binding protein; FLN1; Nonmuscle filamin
Type:
Nuclear receptor co-regulator; Actin binding protein
Mass (Da):
280739
Number AA:
2647
UniProt ID:
P21333
International Prot ID:
IPI00333541
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0015629
GO:0005938
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0034988
GO:0034989
GO:0048365
PhosphoSite+
KinaseNET
Biological Process:
GO:0051764
GO:0031532
GO:0051220
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S2
_
_
_
_
_
_
M
S
S
S
H
S
R
A
G
Site 2
S3
_
_
_
_
_
M
S
S
S
H
S
R
A
G
Q
Site 3
S4
_
_
_
_
M
S
S
S
H
S
R
A
G
Q
S
Site 4
S6
_
_
M
S
S
S
H
S
R
A
G
Q
S
A
A
Site 5
S11
S
H
S
R
A
G
Q
S
A
A
G
A
A
P
G
Site 6
T23
A
P
G
G
G
V
D
T
R
D
A
E
M
P
A
Site 7
T31
R
D
A
E
M
P
A
T
E
K
D
L
A
E
D
Site 8
S61
N
E
H
L
K
C
V
S
K
R
I
A
N
L
Q
Site 9
T69
K
R
I
A
N
L
Q
T
D
L
S
D
G
L
R
Site 10
S72
A
N
L
Q
T
D
L
S
D
G
L
R
L
I
A
Site 11
S85
I
A
L
L
E
V
L
S
Q
K
K
M
H
R
K
Site 12
T98
R
K
H
N
Q
R
P
T
F
R
Q
M
Q
L
E
Site 13
T167
D
E
E
A
K
K
Q
T
P
K
Q
R
L
L
G
Site 14
T186
K
L
P
Q
L
P
I
T
N
F
S
R
D
W
Q
Site 15
S189
Q
L
P
I
T
N
F
S
R
D
W
Q
S
G
R
Site 16
S194
N
F
S
R
D
W
Q
S
G
R
A
L
G
A
L
Site 17
S215
G
L
C
P
D
W
D
S
W
D
A
S
K
P
V
Site 18
T223
W
D
A
S
K
P
V
T
N
A
R
E
A
M
Q
Site 19
S256
D
P
N
V
D
E
H
S
V
M
T
Y
L
S
Q
Site 20
Y260
D
E
H
S
V
M
T
Y
L
S
Q
F
P
K
A
Site 21
S262
H
S
V
M
T
Y
L
S
Q
F
P
K
A
K
L
Site 22
Y287
N
P
K
K
A
R
A
Y
G
P
G
I
E
P
T
Site 23
T305
V
K
K
R
A
E
F
T
V
E
T
R
S
A
G
Site 24
Y319
G
Q
G
E
V
L
V
Y
V
E
D
P
A
G
H
Site 25
T333
H
Q
E
E
A
K
V
T
A
N
N
D
K
N
R
Site 26
T341
A
N
N
D
K
N
R
T
F
S
V
W
Y
V
P
Site 27
S343
N
D
K
N
R
T
F
S
V
W
Y
V
P
E
V
Site 28
Y346
N
R
T
F
S
V
W
Y
V
P
E
V
T
G
T
Site 29
S368
A
G
Q
H
I
A
K
S
P
F
E
V
Y
V
D
Site 30
Y373
A
K
S
P
F
E
V
Y
V
D
K
S
Q
G
D
Site 31
S377
F
E
V
Y
V
D
K
S
Q
G
D
A
S
K
V
Site 32
S382
D
K
S
Q
G
D
A
S
K
V
T
A
Q
G
P
Site 33
T385
Q
G
D
A
S
K
V
T
A
Q
G
P
G
L
E
Site 34
S394
Q
G
P
G
L
E
P
S
G
N
I
A
N
K
T
Site 35
T401
S
G
N
I
A
N
K
T
T
Y
F
E
I
F
T
Site 36
Y403
N
I
A
N
K
T
T
Y
F
E
I
F
T
A
G
Site 37
T429
D
P
M
G
Q
K
G
T
V
E
P
Q
L
E
A
Site 38
S440
Q
L
E
A
R
G
D
S
T
Y
R
C
S
Y
Q
Site 39
T441
L
E
A
R
G
D
S
T
Y
R
C
S
Y
Q
P
Site 40
Y442
E
A
R
G
D
S
T
Y
R
C
S
Y
Q
P
T
Site 41
S445
G
D
S
T
Y
R
C
S
Y
Q
P
T
M
E
G
Site 42
Y446
D
S
T
Y
R
C
S
Y
Q
P
T
M
E
G
V
Site 43
T471
P
I
P
R
S
P
Y
T
V
T
V
G
Q
A
C
Site 44
S481
V
G
Q
A
C
N
P
S
A
C
R
A
V
G
R
Site 45
T500
K
G
V
R
V
K
E
T
A
D
F
K
V
Y
T
Site 46
Y506
E
T
A
D
F
K
V
Y
T
K
G
A
G
S
G
Site 47
T507
T
A
D
F
K
V
Y
T
K
G
A
G
S
G
E
Site 48
T518
G
S
G
E
L
K
V
T
V
K
G
P
K
G
E
Site 49
Y538
K
D
L
G
D
G
V
Y
G
F
E
Y
Y
P
M
Site 50
Y542
D
G
V
Y
G
F
E
Y
Y
P
M
V
P
G
T
Site 51
Y543
G
V
Y
G
F
E
Y
Y
P
M
V
P
G
T
Y
Site 52
S564
G
G
Q
N
I
G
R
S
P
F
E
V
K
V
G
Site 53
S594
E
G
G
V
V
G
K
S
A
D
F
V
V
E
A
Site 54
S612
D
V
G
T
L
G
F
S
V
E
G
P
S
Q
A
Site 55
S617
G
F
S
V
E
G
P
S
Q
A
K
I
E
C
D
Site 56
Y635
D
G
S
C
D
V
R
Y
W
P
Q
E
A
G
E
Site 57
Y643
W
P
Q
E
A
G
E
Y
A
V
H
V
L
C
N
Site 58
S657
N
S
E
D
I
R
L
S
P
F
M
A
D
I
R
Site 59
T685
R
G
P
G
L
E
K
T
G
V
A
V
N
K
P
Site 60
T696
V
N
K
P
A
E
F
T
V
D
A
K
H
G
G
Site 61
T730
V
K
D
N
G
N
G
T
Y
S
C
S
Y
V
P
Site 62
Y731
K
D
N
G
N
G
T
Y
S
C
S
Y
V
P
R
Site 63
S732
D
N
G
N
G
T
Y
S
C
S
Y
V
P
R
K
Site 64
S734
G
N
G
T
Y
S
C
S
Y
V
P
R
K
P
V
Site 65
Y735
N
G
T
Y
S
C
S
Y
V
P
R
K
P
V
K
Site 66
T744
P
R
K
P
V
K
H
T
A
M
V
S
W
G
G
Site 67
S753
M
V
S
W
G
G
V
S
I
P
N
S
P
F
R
Site 68
S757
G
G
V
S
I
P
N
S
P
F
R
V
N
V
G
Site 69
S767
R
V
N
V
G
A
G
S
H
P
N
K
V
K
V
Site 70
Y775
H
P
N
K
V
K
V
Y
G
P
G
V
A
K
T
Site 71
T782
Y
G
P
G
V
A
K
T
G
L
K
A
H
E
P
Site 72
T790
G
L
K
A
H
E
P
T
Y
F
T
V
D
C
A
Site 73
Y791
L
K
A
H
E
P
T
Y
F
T
V
D
C
A
E
Site 74
T793
A
H
E
P
T
Y
F
T
V
D
C
A
E
A
G
Site 75
S805
E
A
G
Q
G
D
V
S
I
G
I
K
C
A
P
Site 76
T833
I
I
R
N
D
N
D
T
F
T
V
K
Y
T
P
Site 77
T835
R
N
D
N
D
T
F
T
V
K
Y
T
P
R
G
Site 78
Y838
N
D
T
F
T
V
K
Y
T
P
R
G
A
G
S
Site 79
T839
D
T
F
T
V
K
Y
T
P
R
G
A
G
S
Y
Site 80
S860
A
D
Q
A
T
P
T
S
P
I
R
V
K
V
E
Site 81
S869
I
R
V
K
V
E
P
S
H
D
A
S
K
V
K
Site 82
S873
V
E
P
S
H
D
A
S
K
V
K
A
E
G
P
Site 83
S883
K
A
E
G
P
G
L
S
R
T
G
V
E
L
G
Site 84
T885
E
G
P
G
L
S
R
T
G
V
E
L
G
K
P
Site 85
T896
L
G
K
P
T
H
F
T
V
N
A
K
A
A
G
Site 86
S912
G
K
L
D
V
Q
F
S
G
L
T
K
G
D
A
Site 87
T915
D
V
Q
F
S
G
L
T
K
G
D
A
V
R
D
Site 88
T932
I
I
D
H
H
D
N
T
Y
T
V
K
Y
T
P
Site 89
Y933
I
D
H
H
D
N
T
Y
T
V
K
Y
T
P
V
Site 90
T934
D
H
H
D
N
T
Y
T
V
K
Y
T
P
V
Q
Site 91
Y937
D
N
T
Y
T
V
K
Y
T
P
V
Q
Q
G
P
Site 92
T938
N
T
Y
T
V
K
Y
T
P
V
Q
Q
G
P
V
Site 93
S959
G
G
D
P
I
P
K
S
P
F
S
V
A
V
S
Site 94
S966
S
P
F
S
V
A
V
S
P
S
L
D
L
S
K
Site 95
S968
F
S
V
A
V
S
P
S
L
D
L
S
K
I
K
Site 96
T992
V
G
K
D
Q
E
F
T
V
K
S
K
G
A
G
Site 97
S995
D
Q
E
F
T
V
K
S
K
G
A
G
G
Q
G
Site 98
S1006
G
G
Q
G
K
V
A
S
K
I
V
G
P
S
G
Site 99
S1029
P
G
L
G
A
D
N
S
V
V
R
F
L
P
R
Site 100
Y1041
L
P
R
E
E
G
P
Y
E
V
E
V
T
Y
D
Site 101
T1046
G
P
Y
E
V
E
V
T
Y
D
G
V
P
V
P
Site 102
Y1047
P
Y
E
V
E
V
T
Y
D
G
V
P
V
P
G
Site 103
S1055
D
G
V
P
V
P
G
S
P
F
P
L
E
A
V
Site 104
S1081
G
P
G
L
Q
G
G
S
A
G
S
P
A
R
F
Site 105
S1084
L
Q
G
G
S
A
G
S
P
A
R
F
T
I
D
Site 106
T1089
A
G
S
P
A
R
F
T
I
D
T
K
G
A
G
Site 107
T1092
P
A
R
F
T
I
D
T
K
G
A
G
T
G
G
Site 108
T1121
C
L
D
N
G
D
G
T
C
S
V
S
Y
V
P
Site 109
S1123
D
N
G
D
G
T
C
S
V
S
Y
V
P
T
E
Site 110
S1125
G
D
G
T
C
S
V
S
Y
V
P
T
E
P
G
Site 111
Y1126
D
G
T
C
S
V
S
Y
V
P
T
E
P
G
D
Site 112
T1129
C
S
V
S
Y
V
P
T
E
P
G
D
Y
N
I
Site 113
S1148
A
D
T
H
I
P
G
S
P
F
K
A
H
V
V
Site 114
S1161
V
V
P
C
F
D
A
S
K
V
K
C
S
G
P
Site 115
T1174
G
P
G
L
E
R
A
T
A
G
E
V
G
Q
F
Site 116
Y1208
A
G
L
P
A
E
V
Y
I
Q
D
H
G
D
G
Site 117
T1216
I
Q
D
H
G
D
G
T
H
T
I
T
Y
I
P
Site 118
T1218
D
H
G
D
G
T
H
T
I
T
Y
I
P
L
C
Site 119
Y1261
D
T
S
G
V
Q
C
Y
G
P
G
I
E
G
Q
Site 120
T1275
Q
G
V
F
R
E
A
T
T
E
F
S
V
D
A
Site 121
T1286
S
V
D
A
R
A
L
T
Q
T
G
G
P
H
V
Site 122
T1288
D
A
R
A
L
T
Q
T
G
G
P
H
V
K
A
Site 123
S1301
K
A
R
V
A
N
P
S
G
N
L
T
E
T
Y
Site 124
T1305
A
N
P
S
G
N
L
T
E
T
Y
V
Q
D
R
Site 125
T1307
P
S
G
N
L
T
E
T
Y
V
Q
D
R
G
D
Site 126
Y1308
S
G
N
L
T
E
T
Y
V
Q
D
R
G
D
G
Site 127
Y1317
Q
D
R
G
D
G
M
Y
K
V
E
Y
T
P
Y
Site 128
Y1321
D
G
M
Y
K
V
E
Y
T
P
Y
E
E
G
L
Site 129
T1322
G
M
Y
K
V
E
Y
T
P
Y
E
E
G
L
H
Site 130
Y1324
Y
K
V
E
Y
T
P
Y
E
E
G
L
H
S
V
Site 131
S1330
P
Y
E
E
G
L
H
S
V
D
V
T
Y
D
G
Site 132
T1334
G
L
H
S
V
D
V
T
Y
D
G
S
P
V
P
Site 133
Y1335
L
H
S
V
D
V
T
Y
D
G
S
P
V
P
S
Site 134
S1338
V
D
V
T
Y
D
G
S
P
V
P
S
S
P
F
Site 135
S1342
Y
D
G
S
P
V
P
S
S
P
F
Q
V
P
V
Site 136
S1343
D
G
S
P
V
P
S
S
P
F
Q
V
P
V
T
Site 137
T1350
S
P
F
Q
V
P
V
T
E
G
C
D
P
S
R
Site 138
S1356
V
T
E
G
C
D
P
S
R
V
R
V
H
G
P
Site 139
T1370
P
G
I
Q
S
G
T
T
N
K
P
N
K
F
T
Site 140
T1377
T
N
K
P
N
K
F
T
V
E
T
R
G
A
G
Site 141
S1401
G
P
S
E
A
K
M
S
C
M
D
N
K
D
G
Site 142
S1411
D
N
K
D
G
S
C
S
V
E
Y
I
P
Y
E
Site 143
Y1414
D
G
S
C
S
V
E
Y
I
P
Y
E
A
G
T
Site 144
Y1417
C
S
V
E
Y
I
P
Y
E
A
G
T
Y
S
L
Site 145
Y1422
I
P
Y
E
A
G
T
Y
S
L
N
V
T
Y
G
Site 146
S1423
P
Y
E
A
G
T
Y
S
L
N
V
T
Y
G
G
Site 147
T1427
G
T
Y
S
L
N
V
T
Y
G
G
H
Q
V
P
Site 148
S1436
G
G
H
Q
V
P
G
S
P
F
K
V
P
V
H
Site 149
T1446
K
V
P
V
H
D
V
T
D
A
S
K
V
K
C
Site 150
S1449
V
H
D
V
T
D
A
S
K
V
K
C
S
G
P
Site 151
S1454
D
A
S
K
V
K
C
S
G
P
G
L
S
P
G
Site 152
S1459
K
C
S
G
P
G
L
S
P
G
M
V
R
A
N
Site 153
S1470
V
R
A
N
L
P
Q
S
F
Q
V
D
T
S
K
Site 154
T1475
P
Q
S
F
Q
V
D
T
S
K
A
G
V
A
P
Site 155
S1476
Q
S
F
Q
V
D
T
S
K
A
G
V
A
P
L
Site 156
T1506
V
V
D
N
A
D
G
T
Q
T
V
N
Y
V
P
Site 157
T1508
D
N
A
D
G
T
Q
T
V
N
Y
V
P
S
R
Site 158
Y1511
D
G
T
Q
T
V
N
Y
V
P
S
R
E
G
P
Site 159
S1520
P
S
R
E
G
P
Y
S
I
S
V
L
Y
G
D
Site 160
S1522
R
E
G
P
Y
S
I
S
V
L
Y
G
D
E
E
Site 161
Y1525
P
Y
S
I
S
V
L
Y
G
D
E
E
V
P
R
Site 162
S1533
G
D
E
E
V
P
R
S
P
F
K
V
K
V
L
Site 163
T1542
F
K
V
K
V
L
P
T
H
D
A
S
K
V
K
Site 164
S1546
V
L
P
T
H
D
A
S
K
V
K
A
S
G
P
Site 165
T1558
S
G
P
G
L
N
T
T
G
V
P
A
S
L
P
Site 166
T1594
P
E
G
K
P
K
K
T
H
I
Q
D
N
H
D
Site 167
T1603
I
Q
D
N
H
D
G
T
Y
T
V
A
Y
V
P
Site 168
Y1604
Q
D
N
H
D
G
T
Y
T
V
A
Y
V
P
D
Site 169
T1605
D
N
H
D
G
T
Y
T
V
A
Y
V
P
D
V
Site 170
Y1608
D
G
T
Y
T
V
A
Y
V
P
D
V
T
G
R
Site 171
T1617
P
D
V
T
G
R
Y
T
I
L
I
K
Y
G
G
Site 172
Y1622
R
Y
T
I
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I
K
Y
G
G
D
E
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P
F
Site 173
S1630
G
G
D
E
I
P
F
S
P
Y
R
V
R
A
V
Site 174
Y1632
D
E
I
P
F
S
P
Y
R
V
R
A
V
P
T
Site 175
T1676
E
T
V
I
T
V
D
T
K
A
A
G
K
G
K
Site 176
T1687
G
K
G
K
V
T
C
T
V
C
T
P
D
G
S
Site 177
T1690
K
V
T
C
T
V
C
T
P
D
G
S
E
V
D
Site 178
T1707
V
V
E
N
E
D
G
T
F
D
I
F
Y
T
A
Site 179
Y1712
D
G
T
F
D
I
F
Y
T
A
P
Q
P
G
K
Site 180
Y1720
T
A
P
Q
P
G
K
Y
V
I
C
V
R
F
G
Site 181
S1734
G
G
E
H
V
P
N
S
P
F
Q
V
T
A
L
Site 182
T1739
P
N
S
P
F
Q
V
T
A
L
A
G
D
Q
P
Site 183
S1747
A
L
A
G
D
Q
P
S
V
Q
P
P
L
R
S
Site 184
S1754
S
V
Q
P
P
L
R
S
Q
Q
L
A
P
Q
Y
Site 185
Y1761
S
Q
Q
L
A
P
Q
Y
T
Y
A
Q
G
G
Q
Site 186
T1762
Q
Q
L
A
P
Q
Y
T
Y
A
Q
G
G
Q
Q
Site 187
Y1763
Q
L
A
P
Q
Y
T
Y
A
Q
G
G
Q
Q
T
Site 188
S1812
T
G
E
V
R
M
P
S
G
K
V
A
Q
P
T
Site 189
T1827
I
T
D
N
K
D
G
T
V
T
V
R
Y
A
P
Site 190
T1829
D
N
K
D
G
T
V
T
V
R
Y
A
P
S
E
Site 191
Y1832
D
G
T
V
T
V
R
Y
A
P
S
E
A
G
L
Site 192
S1835
V
T
V
R
Y
A
P
S
E
A
G
L
H
E
M
Site 193
Y1846
L
H
E
M
D
I
R
Y
D
N
M
H
I
P
G
Site 194
S1854
D
N
M
H
I
P
G
S
P
L
Q
F
Y
V
D
Site 195
Y1859
P
G
S
P
L
Q
F
Y
V
D
Y
V
N
C
G
Site 196
Y1862
P
L
Q
F
Y
V
D
Y
V
N
C
G
H
V
T
Site 197
Y1871
N
C
G
H
V
T
A
Y
G
P
G
L
T
H
G
Site 198
T1885
G
V
V
N
K
P
A
T
F
T
V
N
T
K
D
Site 199
T1887
V
N
K
P
A
T
F
T
V
N
T
K
D
A
G
Site 200
S1899
D
A
G
E
G
G
L
S
L
A
I
E
G
P
S
Site 201
T1913
S
K
A
E
I
S
C
T
D
N
Q
D
G
T
C
Site 202
T1919
C
T
D
N
Q
D
G
T
C
S
V
S
Y
L
P
Site 203
S1921
D
N
Q
D
G
T
C
S
V
S
Y
L
P
V
L
Site 204
Y1932
L
P
V
L
P
G
D
Y
S
I
L
V
K
Y
N
Site 205
S1933
P
V
L
P
G
D
Y
S
I
L
V
K
Y
N
E
Site 206
Y1938
D
Y
S
I
L
V
K
Y
N
E
Q
H
V
P
G
Site 207
S1946
N
E
Q
H
V
P
G
S
P
F
T
A
R
V
T
Site 208
T1949
H
V
P
G
S
P
F
T
A
R
V
T
G
D
D
Site 209
T1953
S
P
F
T
A
R
V
T
G
D
D
S
M
R
M
Site 210
S1957
A
R
V
T
G
D
D
S
M
R
M
S
H
L
K
Site 211
S1961
G
D
D
S
M
R
M
S
H
L
K
V
G
S
A
Site 212
S1991
T
A
T
V
V
P
P
S
G
R
E
E
P
C
L
Site 213
S2010
R
N
G
H
V
G
I
S
F
V
P
K
E
T
G
Site 214
S2032
K
N
G
Q
H
V
A
S
S
P
I
P
V
V
I
Site 215
S2033
N
G
Q
H
V
A
S
S
P
I
P
V
V
I
S
Site 216
S2048
Q
S
E
I
G
D
A
S
R
V
R
V
S
G
Q
Site 217
S2053
D
A
S
R
V
R
V
S
G
Q
G
L
H
E
G
Site 218
T2062
Q
G
L
H
E
G
H
T
F
E
P
A
E
F
I
Site 219
T2072
P
A
E
F
I
I
D
T
R
D
A
G
Y
G
G
Site 220
Y2077
I
D
T
R
D
A
G
Y
G
G
L
S
L
S
I
Site 221
S2081
D
A
G
Y
G
G
L
S
L
S
I
E
G
P
S
Site 222
S2083
G
Y
G
G
L
S
L
S
I
E
G
P
S
K
V
Site 223
S2088
S
L
S
I
E
G
P
S
K
V
D
I
N
T
E
Site 224
T2094
P
S
K
V
D
I
N
T
E
D
L
E
D
G
T
Site 225
T2101
T
E
D
L
E
D
G
T
C
R
V
T
Y
C
P
Site 226
T2105
E
D
G
T
C
R
V
T
Y
C
P
T
E
P
G
Site 227
Y2106
D
G
T
C
R
V
T
Y
C
P
T
E
P
G
N
Site 228
S2128
A
D
Q
H
V
P
G
S
P
F
S
V
K
V
T
Site 229
S2131
H
V
P
G
S
P
F
S
V
K
V
T
G
E
G
Site 230
T2135
S
P
F
S
V
K
V
T
G
E
G
R
V
K
E
Site 231
S2143
G
E
G
R
V
K
E
S
I
T
R
R
R
R
A
Site 232
T2145
G
R
V
K
E
S
I
T
R
R
R
R
A
P
S
Site 233
S2152
T
R
R
R
R
A
P
S
V
A
N
V
G
S
H
Site 234
S2158
P
S
V
A
N
V
G
S
H
C
D
L
S
L
K
Site 235
S2163
V
G
S
H
C
D
L
S
L
K
I
P
E
I
S
Site 236
S2170
S
L
K
I
P
E
I
S
I
Q
D
M
T
A
Q
Site 237
T2175
E
I
S
I
Q
D
M
T
A
Q
V
T
S
P
S
Site 238
S2180
D
M
T
A
Q
V
T
S
P
S
G
K
T
H
E
Site 239
T2197
I
V
E
G
E
N
H
T
Y
C
I
R
F
V
P
Site 240
Y2198
V
E
G
E
N
H
T
Y
C
I
R
F
V
P
A
Site 241
T2211
P
A
E
M
G
T
H
T
V
S
V
K
Y
K
G
Site 242
S2224
K
G
Q
H
V
P
G
S
P
F
Q
F
T
V
G
Site 243
T2229
P
G
S
P
F
Q
F
T
V
G
P
L
G
E
G
Site 244
S2260
A
G
V
P
A
E
F
S
I
W
T
R
E
A
G
Site 245
S2284
G
P
S
K
A
E
I
S
F
E
D
R
K
D
G
Site 246
S2292
F
E
D
R
K
D
G
S
C
G
V
A
Y
V
V
Site 247
Y2297
D
G
S
C
G
V
A
Y
V
V
Q
E
P
G
D
Site 248
Y2305
V
V
Q
E
P
G
D
Y
E
V
S
V
K
F
N
Site 249
S2308
E
P
G
D
Y
E
V
S
V
K
F
N
E
E
H
Site 250
S2319
N
E
E
H
I
P
D
S
P
F
V
V
P
V
A
Site 251
S2327
P
F
V
V
P
V
A
S
P
S
G
D
A
R
R
Site 252
S2329
V
V
P
V
A
S
P
S
G
D
A
R
R
L
T
Site 253
T2336
S
G
D
A
R
R
L
T
V
S
S
L
Q
E
S
Site 254
S2338
D
A
R
R
L
T
V
S
S
L
Q
E
S
G
L
Site 255
S2339
A
R
R
L
T
V
S
S
L
Q
E
S
G
L
K
Site 256
S2343
T
V
S
S
L
Q
E
S
G
L
K
V
N
Q
P
Site 257
S2370
A
I
D
A
K
V
H
S
P
S
G
A
L
E
E
Site 258
S2372
D
A
K
V
H
S
P
S
G
A
L
E
E
C
Y
Site 259
Y2379
S
G
A
L
E
E
C
Y
V
T
E
I
D
Q
D
Site 260
T2381
A
L
E
E
C
Y
V
T
E
I
D
Q
D
K
Y
Site 261
Y2388
T
E
I
D
Q
D
K
Y
A
V
R
F
I
P
R
Site 262
Y2400
I
P
R
E
N
G
V
Y
L
I
D
V
K
F
N
Site 263
T2409
I
D
V
K
F
N
G
T
H
I
P
G
S
P
F
Site 264
S2414
N
G
T
H
I
P
G
S
P
F
K
I
R
V
G
Site 265
S2470
S
V
T
I
D
G
P
S
K
V
K
M
D
C
Q
Site 266
Y2483
C
Q
E
C
P
E
G
Y
R
V
T
Y
T
P
M
Site 267
T2486
C
P
E
G
Y
R
V
T
Y
T
P
M
A
P
G
Site 268
Y2487
P
E
G
Y
R
V
T
Y
T
P
M
A
P
G
S
Site 269
T2488
E
G
Y
R
V
T
Y
T
P
M
A
P
G
S
Y
Site 270
S2498
A
P
G
S
Y
L
I
S
I
K
Y
G
G
P
Y
Site 271
Y2501
S
Y
L
I
S
I
K
Y
G
G
P
Y
H
I
G
Site 272
Y2505
S
I
K
Y
G
G
P
Y
H
I
G
G
S
P
F
Site 273
S2510
G
P
Y
H
I
G
G
S
P
F
K
A
K
V
T
Site 274
S2523
V
T
G
P
R
L
V
S
N
H
S
L
H
E
T
Site 275
S2526
P
R
L
V
S
N
H
S
L
H
E
T
S
S
V
Site 276
T2530
S
N
H
S
L
H
E
T
S
S
V
F
V
D
S
Site 277
S2532
H
S
L
H
E
T
S
S
V
F
V
D
S
L
T
Site 278
S2558
G
P
G
P
A
D
A
S
K
V
V
A
K
G
L
Site 279
S2568
V
A
K
G
L
G
L
S
K
A
Y
V
G
Q
K
Site 280
Y2571
G
L
G
L
S
K
A
Y
V
G
Q
K
S
S
F
Site 281
S2576
K
A
Y
V
G
Q
K
S
S
F
T
V
D
C
S
Site 282
S2577
A
Y
V
G
Q
K
S
S
F
T
V
D
C
S
K
Site 283
T2579
V
G
Q
K
S
S
F
T
V
D
C
S
K
A
G
Site 284
S2583
S
S
F
T
V
D
C
S
K
A
G
N
N
M
L
Site 285
T2599
V
G
V
H
G
P
R
T
P
C
E
E
I
L
V
Site 286
Y2614
K
H
V
G
S
R
L
Y
S
V
S
Y
L
L
K
Site 287
S2615
H
V
G
S
R
L
Y
S
V
S
Y
L
L
K
D
Site 288
S2617
G
S
R
L
Y
S
V
S
Y
L
L
K
D
K
G
Site 289
Y2618
S
R
L
Y
S
V
S
Y
L
L
K
D
K
G
E
Site 290
T2627
L
K
D
K
G
E
Y
T
L
V
V
K
W
G
D
Site 291
S2640
G
D
E
H
I
P
G
S
P
Y
R
V
V
V
P
Site 292
Y2642
E
H
I
P
G
S
P
Y
R
V
V
V
P
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation