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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ACO1
Full Name:
Cytoplasmic aconitate hydratase
Alias:
Aconitase; Aconitate hydratase; Citrate hydro-lyase; EC 4.2.1.3; Ferritin repressor protein; IRE1; IRE-BP 1; IREBP1; Iron regulatory protein 1; IRP1
Type:
Enzyme, translation initiation complex
Mass (Da):
98399
Number AA:
889
UniProt ID:
P21399
International Prot ID:
IPI00008485
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0005829
GO:0005783
Uniprot
OncoNet
Molecular Function:
GO:0051539
GO:0003994
GO:0005506
PhosphoSite+
KinaseNET
Biological Process:
GO:0006101
GO:0010040
GO:0006099
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S30
N
L
N
K
L
E
D
S
R
Y
G
R
L
P
F
Site 2
Y32
N
K
L
E
D
S
R
Y
G
R
L
P
F
S
I
Site 3
S127
A
D
L
V
I
D
H
S
I
Q
V
D
F
N
R
Site 4
S138
D
F
N
R
R
A
D
S
L
Q
K
N
Q
D
L
Site 5
Y184
I
H
Q
V
N
L
E
Y
L
A
R
V
V
F
D
Site 6
Y195
V
V
F
D
Q
D
G
Y
Y
Y
P
D
S
L
V
Site 7
Y196
V
F
D
Q
D
G
Y
Y
Y
P
D
S
L
V
G
Site 8
Y197
F
D
Q
D
G
Y
Y
Y
P
D
S
L
V
G
T
Site 9
S200
D
G
Y
Y
Y
P
D
S
L
V
G
T
D
S
H
Site 10
T204
Y
P
D
S
L
V
G
T
D
S
H
T
T
M
I
Site 11
S206
D
S
L
V
G
T
D
S
H
T
T
M
I
D
G
Site 12
S236
V
M
L
G
Q
P
I
S
M
V
L
P
Q
V
I
Site 13
Y245
V
L
P
Q
V
I
G
Y
R
L
M
G
K
P
H
Site 14
T318
P
V
D
E
V
S
I
T
Y
L
V
Q
T
G
R
Site 15
Y319
V
D
E
V
S
I
T
Y
L
V
Q
T
G
R
D
Site 16
Y332
R
D
E
E
K
L
K
Y
I
K
K
Y
L
Q
A
Site 17
Y336
K
L
K
Y
I
K
K
Y
L
Q
A
V
G
M
F
Site 18
S350
F
R
D
F
N
D
P
S
Q
D
P
D
F
T
Q
Site 19
T356
P
S
Q
D
P
D
F
T
Q
V
V
E
L
D
L
Site 20
S371
K
T
V
V
P
C
C
S
G
P
K
R
P
Q
D
Site 21
S383
P
Q
D
K
V
A
V
S
D
M
K
K
D
F
E
Site 22
Y417
N
D
H
K
T
F
I
Y
D
N
T
E
F
T
L
Site 23
Y466
A
G
L
N
V
M
P
Y
I
K
T
S
L
S
P
Site 24
T479
S
P
G
S
G
V
V
T
Y
Y
L
Q
E
S
G
Site 25
Y480
P
G
S
G
V
V
T
Y
Y
L
Q
E
S
G
V
Site 26
Y490
Q
E
S
G
V
M
P
Y
L
S
Q
L
G
F
D
Site 27
T546
E
G
R
V
H
P
N
T
R
A
N
Y
L
A
S
Site 28
Y550
H
P
N
T
R
A
N
Y
L
A
S
P
P
L
V
Site 29
Y613
P
G
M
F
K
E
V
Y
Q
K
I
E
T
V
N
Site 30
T618
E
V
Y
Q
K
I
E
T
V
N
E
S
W
N
A
Site 31
S622
K
I
E
T
V
N
E
S
W
N
A
L
A
T
P
Site 32
T628
E
S
W
N
A
L
A
T
P
S
D
K
L
F
F
Site 33
T641
F
F
W
N
S
K
S
T
Y
I
K
S
P
P
F
Site 34
Y642
F
W
N
S
K
S
T
Y
I
K
S
P
P
F
F
Site 35
S645
S
K
S
T
Y
I
K
S
P
P
F
F
E
N
L
Site 36
T653
P
P
F
F
E
N
L
T
L
D
L
Q
P
P
K
Site 37
T676
L
N
L
G
D
S
V
T
T
D
H
I
S
P
A
Site 38
S681
S
V
T
T
D
H
I
S
P
A
G
N
I
A
R
Site 39
S690
A
G
N
I
A
R
N
S
P
A
A
R
Y
L
T
Site 40
Y695
R
N
S
P
A
A
R
Y
L
T
N
R
G
L
T
Site 41
T697
S
P
A
A
R
Y
L
T
N
R
G
L
T
P
R
Site 42
T702
Y
L
T
N
R
G
L
T
P
R
E
F
N
S
Y
Site 43
S708
L
T
P
R
E
F
N
S
Y
G
S
R
R
G
N
Site 44
Y709
T
P
R
E
F
N
S
Y
G
S
R
R
G
N
D
Site 45
S711
R
E
F
N
S
Y
G
S
R
R
G
N
D
A
V
Site 46
Y759
V
F
D
A
A
E
R
Y
Q
Q
A
G
L
P
L
Site 47
Y774
I
V
L
A
G
K
E
Y
G
A
G
S
S
R
D
Site 48
S778
G
K
E
Y
G
A
G
S
S
R
D
W
A
A
K
Site 49
S799
I
K
A
V
L
A
E
S
Y
E
R
I
H
R
S
Site 50
Y800
K
A
V
L
A
E
S
Y
E
R
I
H
R
S
N
Site 51
S806
S
Y
E
R
I
H
R
S
N
L
V
G
M
G
V
Site 52
T836
L
T
G
Q
E
R
Y
T
I
I
I
P
E
N
L
Site 53
T858
V
K
L
D
T
G
K
T
F
Q
A
V
M
R
F
Site 54
T867
Q
A
V
M
R
F
D
T
D
V
E
L
T
Y
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation