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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ABCB4
Full Name:
Multidrug resistance protein 3
Alias:
ATP-binding cassette, sub-family B (MDR/TAP) member 4; EC 3.6.3.44; GBD1; MDR2; MDR3; PFIC-3; P-glycoprotein 3; PGY3
Type:
Transporter; Membrane protein, integral; EC 3.6.3.44; Hydrolase
Mass (Da):
141523
Number AA:
1286
UniProt ID:
P21439
International Prot ID:
IPI00218731
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005887
GO:0005624
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0008559
PhosphoSite+
KinaseNET
Biological Process:
GO:0006629
GO:0042493
GO:0055085
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T15
N
G
T
A
W
R
P
T
S
A
E
G
D
F
E
Site 2
S16
G
T
A
W
R
P
T
S
A
E
G
D
F
E
L
Site 3
S26
G
D
F
E
L
G
I
S
S
K
Q
K
R
K
K
Site 4
T34
S
K
Q
K
R
K
K
T
K
T
V
K
M
I
G
Site 5
T36
Q
K
R
K
K
T
K
T
V
K
M
I
G
V
L
Site 6
Y48
G
V
L
T
L
F
R
Y
S
D
W
Q
D
K
L
Site 7
T88
M
T
D
K
F
V
D
T
A
G
N
F
S
F
P
Site 8
T114
K
I
L
E
E
E
M
T
R
Y
A
Y
Y
Y
S
Site 9
Y116
L
E
E
E
M
T
R
Y
A
Y
Y
Y
S
G
L
Site 10
Y118
E
E
M
T
R
Y
A
Y
Y
Y
S
G
L
G
A
Site 11
Y119
E
M
T
R
Y
A
Y
Y
Y
S
G
L
G
A
G
Site 12
Y120
M
T
R
Y
A
Y
Y
Y
S
G
L
G
A
G
V
Site 13
T170
G
W
F
D
I
N
D
T
T
E
L
N
T
R
L
Site 14
T178
T
E
L
N
T
R
L
T
D
D
I
S
K
I
S
Site 15
S182
T
R
L
T
D
D
I
S
K
I
S
E
G
I
G
Site 16
Y279
Q
N
K
E
L
E
R
Y
Q
K
H
L
E
N
A
Site 17
S325
Y
G
S
T
L
V
I
S
K
E
Y
T
I
G
N
Site 18
S379
D
N
N
P
K
I
D
S
F
S
E
R
G
H
K
Site 19
S381
N
P
K
I
D
S
F
S
E
R
G
H
K
P
D
Site 20
S389
E
R
G
H
K
P
D
S
I
K
G
N
L
E
F
Site 21
Y403
F
N
D
V
H
F
S
Y
P
S
R
A
N
V
K
Site 22
S436
G
S
S
G
C
G
K
S
T
T
V
Q
L
I
Q
Site 23
T438
S
G
C
G
K
S
T
T
V
Q
L
I
Q
R
L
Site 24
Y446
V
Q
L
I
Q
R
L
Y
D
P
D
E
G
T
I
Site 25
T452
L
Y
D
P
D
E
G
T
I
N
I
D
G
Q
D
Site 26
T524
K
L
P
Q
K
F
D
T
L
V
G
E
R
G
A
Site 27
S534
G
E
R
G
A
Q
L
S
G
G
Q
K
Q
R
I
Site 28
T565
E
A
T
S
A
L
D
T
E
S
E
A
E
V
Q
Site 29
S567
T
S
A
L
D
T
E
S
E
A
E
V
Q
A
A
Site 30
T584
K
A
R
E
G
R
T
T
I
V
I
A
H
R
L
Site 31
S615
I
V
E
Q
G
S
H
S
E
L
M
K
K
E
G
Site 32
Y624
L
M
K
K
E
G
V
Y
F
K
L
V
N
M
Q
Site 33
S635
V
N
M
Q
T
S
G
S
Q
I
Q
S
E
E
F
Site 34
S639
T
S
G
S
Q
I
Q
S
E
E
F
E
L
N
D
Site 35
T651
L
N
D
E
K
A
A
T
R
M
A
P
N
G
W
Site 36
S666
K
S
R
L
F
R
H
S
T
Q
K
N
L
K
N
Site 37
T667
S
R
L
F
R
H
S
T
Q
K
N
L
K
N
S
Site 38
S674
T
Q
K
N
L
K
N
S
Q
M
C
Q
K
S
L
Site 39
S680
N
S
Q
M
C
Q
K
S
L
D
V
E
T
D
G
Site 40
T706
K
V
L
K
L
N
K
T
E
W
P
Y
F
V
V
Site 41
T784
G
K
A
G
E
I
L
T
R
R
L
R
S
M
A
Site 42
S809
W
F
D
D
H
K
N
S
T
G
A
L
S
T
R
Site 43
S814
K
N
S
T
G
A
L
S
T
R
L
A
T
D
A
Site 44
T905
E
A
I
E
N
I
R
T
V
V
S
L
T
Q
E
Site 45
T910
I
R
T
V
V
S
L
T
Q
E
R
K
F
E
S
Site 46
Y919
E
R
K
F
E
S
M
Y
V
E
K
L
Y
G
P
Site 47
Y924
S
M
Y
V
E
K
L
Y
G
P
Y
R
N
S
V
Site 48
Y997
A
S
S
F
A
P
D
Y
A
K
A
K
L
S
A
Site 49
S1019
E
R
Q
P
L
I
D
S
Y
S
E
E
G
L
K
Site 50
Y1020
R
Q
P
L
I
D
S
Y
S
E
E
G
L
K
P
Site 51
S1021
Q
P
L
I
D
S
Y
S
E
E
G
L
K
P
D
Site 52
Y1043
F
N
E
V
V
F
N
Y
P
T
R
A
N
V
P
Site 53
T1077
S
S
G
C
G
K
S
T
V
V
Q
L
L
E
R
Site 54
S1132
E
P
I
L
F
D
C
S
I
A
E
N
I
A
Y
Site 55
Y1139
S
I
A
E
N
I
A
Y
G
D
N
S
R
V
V
Site 56
S1143
N
I
A
Y
G
D
N
S
R
V
V
S
Q
D
E
Site 57
S1147
G
D
N
S
R
V
V
S
Q
D
E
I
V
S
A
Site 58
Y1171
I
E
T
L
P
H
K
Y
E
T
R
V
G
D
K
Site 59
T1180
T
R
V
G
D
K
G
T
Q
L
S
G
G
Q
K
Site 60
S1183
G
D
K
G
T
Q
L
S
G
G
Q
K
Q
R
I
Site 61
T1214
E
A
T
S
A
L
D
T
E
S
E
K
V
V
Q
Site 62
S1216
T
S
A
L
D
T
E
S
E
K
V
V
Q
E
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation